Evaluation of analgesic activity of turmeric (Curcuma longa Linn.) in Wister rats

Jogdand, Sangita; Bhattacharjee, Jagruti

doi:10.18203/2319-2003.ijbcp20170814

Cited by 13 publications

(12 citation statements)

References 7 publications

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“… 24 In animal models, C longa rhizome extracts were also examined for analgesic and antipyretic activities, and the rhizome extracts showed effective potency on analgesic effect. 25 C citratus is another widely used herb in folklore and traditional medicine. The chemical constituents of essential oil have been examined and it was found that geranial, neral, and myrcene were 3 main active constituents.…”

Section: Discussionmentioning

confidence: 99%

The Distinction of Hot Herbal Compress, Hot Compress, and Topical Diclofenac as Myofascial Pain Syndrome Treatment

Boonruab

Nimpitakpong

Damjuti

2018

J Evid Based Complementary Altern Med

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This randomized controlled trial aimed to investigate the distinctness after treatment among hot herbal compress, hot compress, and topical diclofenac. The registrants were equally divided into groups and received the different treatments including hot herbal compress, hot compress, and topical diclofenac group, which served as the control group. After treatment courses, Visual Analog Scale and 36-Item Short Form Health survey were, respectively, used to establish the level of pain intensity and quality of life. In addition, cervical range of motion and pressure pain threshold were also examined to identify the motional effects. All treatments showed significantly decreased level of pain intensity and increased cervical range of motion, while the intervention groups exhibited extraordinary capability compared with the topical diclofenac group in pressure pain threshold and quality of life. In summary, hot herbal compress holds promise to be an efficacious treatment parallel to hot compress and topical diclofenac.

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Section: Discussionmentioning

confidence: 99%

The Distinction of Hot Herbal Compress, Hot Compress, and Topical Diclofenac as Myofascial Pain Syndrome Treatment

Boonruab

Nimpitakpong

Damjuti

2018

J Evid Based Complementary Altern Med

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“…Curcumin has several beneficial activities such as antioxidant, antimicrobial, anti-inflammatory, analgesic, nephroprotective, and chemotherapeutic properties. [14][15][16][17][18][19][20][21] As amyloid plaques cause oxidative damage to the brains of the AD patients, also generation of free radicals by Aβ, abnormalities in the mitochondria of the cells, inflammation and abnormal changes which affects the natural antioxidant defense are ultimately responsible for the pathophysiology of AD. [22] Thereby, substances which have antioxidant properties like curcumin can be potential therapeutic targets useful in slowing the disease progression.…”

Section: Introductionmentioning

confidence: 99%

Molecular docking study on curcumin and its derivatives as inhibitors of BACE1 in the treatment of Alzheimer's disease

Raghu¹,

Karunanithi²,

Kannan³

et al. 2017

Natl J Physiol Pharm Pharmacol

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Background: Alzheimer's disease (AD) is a progressive neurodegenerative brain disorder, and it is the main cause of dementia in the elderly. At present, no proper cure is available to stop the progression of AD. The neuronal damage in AD is due to the deposition of β-amyloid peptide and tau protein within the brain. Curcumin a curry spice has several beneficial activities such as antioxidant, antimicrobial, anti-inflammatory, and chemotherapeutic properties. Aims and Objectives: The main objective was to perform molecular docking of curcumin and its derivatives with BACE1 to determine its binding efficacy and the absorption, distribution, metabolism, excretion, and toxicity (ADMET) properties of the selected curcumin derivatives. Materials and Methods: Three-dimensional structure of the BACE1 was retrieved from RCSB database in protein data bank format. Total 200 ligand derivatives of curcumin were generated using the software advanced chemistry development/ChemSketch. The rapid virtual screening of the compounds was performed using the docking tool iGEMDOCK version 2.0. The ligands with low binding energy were selected and were analyzed for the drug-relevant properties. The final docking of the ligands was performed using the software AutoDock 4.0, based on the drug-like properties and the binding affinity. Results: Among the four ligands, based on the drug-likeness, the ligand (6Z)-1-(4-hydroxy-3-methoxy-2-nitrophenyl)-7-(4-hydroxy-3-methoxyohenyl) hepta-1,6-diene-3, 5-dione was the best. It had excellent binding energy with good ADMET properties. Conclusion: In this study, using the molecular docking method, a new compound has been identified to inhibit BACE1. This compound can be an effective drug candidate for controlling AD.

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“…al., 2018). Studi yang dilakukan pada tikus dengan memberikan ekstrak kunyit sebanyak dosis 400 mg/kg meunjukkan aktivitas analgesik yang signifikan pada tikus dan aktivitas analgesiknya sebanding dengan aspirin pada 90 dan 120 menit (Jogdand and Bhattacharjee, 2017). Penelitian lain menyebutkan bahwa ekstrak air kunyit dapat mengurangi peradangan akut pada telinga tikus yang dibuat edema, efek ekstrak air kunyit sebanding dengan curcuminoid dan tumeron (Bagad, et.…”

Section: Pendahuluanunclassified

Therapy Low Back Pain With Swedish Massage, Acupressure and Turmeric

2020

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Background: Low back pain is pain that arises below the costal margin and above the inferior gluteal fold. In Traditional Chinese Medicine (TCM) low back pain is referred to as Yao Tong. Low back pain cases experienced by patients are pain that gets worse when exposed to cold air, is too tired and feels stiff and heavy. The patient has low back pain with damp cold pathogenic syndrome. Purpose: To prove the effect of combination therapy for Swedish massage in the back and waist area, acupressure at Shenshu (BL23), Dachangshu (BL25), Taixi (KI3), Taibai (SP3), Fenglong (ST40) and turmeric herbs (Curcuma longa Linn) on low back pain sufferers. Methods: Management of low back pain with Swedish, acupressure and herbal massage methods. Swedish massage therapy is performed on the back and waist area. Acupressure at the points of Shenshu (BL23), Dachangshu (BL25), Taixi (KI3), Taibai (SP3), Fenglong (ST40) with the principle of therapy of kidney and spleen tonification and elimination of cold moist pathogens. The most common herbal therapy for patients is turmeric (Curcuma longa Linn). Results: The curcumin compounds in turmeric can inhibit lipoxygenase, phospholipase A2 and COX-2 so they can reduce low back pain. In the treatment of low back pain, massage and acupressure are performed 2 times a week 12 times. While herbal therapy is given for 42 days taken once a day with a dose of 9 grams of turmeric simplicia. Conlussion: Swedish massage therapy, acupressure and herbs can reduce low back pain.

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Evaluation of analgesic activity of turmeric (Curcuma longa Linn.) in Wister rats

Cited by 13 publications

References 7 publications

The Distinction of Hot Herbal Compress, Hot Compress, and Topical Diclofenac as Myofascial Pain Syndrome Treatment

The Distinction of Hot Herbal Compress, Hot Compress, and Topical Diclofenac as Myofascial Pain Syndrome Treatment

Molecular docking study on curcumin and its derivatives as inhibitors of BACE1 in the treatment of Alzheimer's disease

Therapy Low Back Pain With Swedish Massage, Acupressure and Turmeric

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