Evaluation of Analgesic Activity of the Methanol Extract from the Leaves of Arum palaestinum in Mice and Rats

Qnais, Esam; Bseiso, Yousra; Wedyan, Mohammad; Alkhateeb, Hakam

doi:10.13005/bpj/1216

Cited by 10 publications

(7 citation statements)

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“…These free radicals accumulate in the body counter with biological molecules and disturb the normal structure of cells, leading to free radical-induced diseases such as inflammation, metastasis and cardiovascular disorders (Arshiya, 2013;Ainooson et al, 2009). Therefore, the identification of natural antioxidant may reduce the risk of various chronic diseases involved in free radicals especially inflammation (Qnais et al, 2017). In current study SO, FO and SO+FO showed significant %age inhibition and lowest IC50 values in DPPH assay that represents these oils have excellent antioxidant property.…”

Section: Discussionmentioning

confidence: 50%

Untitled

2021

Pak. J. Pharm. Sci

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Natural oils are rich in polyunsaturated fatty acids (PUFs) like omega 3, omega 6 and other nutrients that boost physical and mental health. Traditionally these oils have been used to treat joint pain associated with several inflammatory conditions. In this study, we investigated the antioxidant and analgesic properties of the sesame oil (SO), fish oil (FO) and combination of these two oils (SO+FO). Different concentrations of the SO, FO and SO+FO combination 0.02-4mg/ml were used for assessing the free radical scavenging activity by DPPH method and the IC50 value was calculated. Acetic acid-induced abdominal writhing test, tail immersion and hot plate models were used to determined analgesic effect. Results showed that both oils were well tolerated as no signs of toxicity or death were noticed during the observational study period. SO+FO combination showed the best antioxidant properties as shown by DPPH assay. Similarly in analgesic models, SO and FO significantly reduced the number of abdominal contractions (p<0.05) however, SO+FO (1:1) exhibited highly significant results (p<0.001) in writhing reflex test. Furthermore, SO and FO both increased the reaction time on a hot plate as well as in tail flick test (p<0.05) whereas, SO+FO significantly increased reaction time (p<0.001) in hot plate and in tail flick test as compared to SO and FO single treatments. Conclusively, our results suggest that the combination of both oils (SO+FO) exhibited significant antioxidant and analgesic potential that it could be considered as one of the active combinations for relieving pain in adjunctive treatment for joint pain associated with rheumatoid arthritis.

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Section: Discussionmentioning

confidence: 50%

Untitled

2021

Pak. J. Pharm. Sci

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“…However, the inflammatory (late) phase occurs 15–30 min after formalin injection in response to the release of several mediators for inflammation, such as bradykinin, prostaglandins, as well as histamines [ 54 , 55 , 56 ]. It is well known that centrally acting analgesic agents, such as opioids, inhibit both the non-inflammatory (early) and inflammatory (late) nociceptive phase, whereas peripherally-acting analgesic agents such as NSAIDs inhibit only the inflammatory (late) nociceptive phase [ 44 , 57 ]. Interestingly, our results demonstrated that Ceratonia siliqua ethanol extract has anti-nociceptive properties in the non-inflammatory and inflammatory phases, which suggest that the ethanol extract of Ceratonia siliqua leaves could have a centrally and peripherally acting analgesic activity.…”

Section: Discussionmentioning

confidence: 99%

Ceratonia siliqua leaves ethanol extracts exert anti-nociceptive and anti-inflammatory effects

Alqudah

Qnais

Wedyan

et al. 2022

Heliyon

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“…T. arjuna exerted better results than Caesalpiniabonducella [ 37 ]. On the contrary, Astragalushamosus, Arum palaestinum, and Inula cuspidate, Murrayakoenigii Linn gave a similar effect as T. arjuna [ 67 , 68 , 69 , 70 ].…”

Section: Discussionmentioning

confidence: 99%

“…A significant pain reduction in the treatment groups than the positive control group indicates the analgesic activity of T arjuna extract. A similar result was observed in Caesalpiniabonducella, Astragalushamosus, Arum palaestinum, Inula cuspidate, Murrayakoenigii Linn., Rhynchosiacapitata DC., Glycine tomentella, Clutiaabyssinica, Scoparia dulcis L., Ficusracemosa Linn., and Limoniastrumfeei [ 35 , 69 , 70 , 71 , 73 , 74 , 75 , 76 , 77 ].…”

Section: Discussionmentioning

confidence: 99%