Evaluation of Analgesic Drugs in Horses

Lumb, William V.; Pippi, N. L.; Kalpravidh, Marissak

doi:10.1007/978-1-4614-7562-0_11

Animal Pain 1983

DOI: 10.1007/978-1-4614-7562-0_11

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Evaluation of Analgesic Drugs in Horses

William V. Lumb

N. L. Pippi

Marissak Kalpravidh

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1986

1994

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Cited by 4 publications

(1 citation statement)

References 16 publications

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“…Thermal stimuli produced by radiant energy, CO, laser or thermodes directed on an area of skin has been used for nociception in humans and several animal species (Steffey et al. 1974: Lumb et al, 1983: Anton et al. 1984: Nast et al.…”

mentioning

confidence: 99%

Evaluation of a microstrain gauge algesimeter for quantitative measurement of nociception in the dog

Quandt¹,

Raffe²,

Reeh

et al. 1994

Vet Pharm & Therapeutics

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mentioning

confidence: 99%

Evaluation of a microstrain gauge algesimeter for quantitative measurement of nociception in the dog

Quandt¹,

Raffe²,

Reeh

et al. 1994

Vet Pharm & Therapeutics

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Initial Treatment of Colic

Rose¹,

Rose

1988

Veterinary Clinics of North America: Equine Practice

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Dose-related effects of ethylketazocine on nociception, behaviour and autonomic responses in the horse

Kamerling

Dequick

Weckman

et al. 1986

Journal of Pharmacy and Pharmacology

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Sensitive methods for measuring the analgesic, physiological and behavioural effects of opioids in the horse have recently been developed. Fentanyl, a prototypic mu-opiate receptor agonist, has been previously shown to produce a syndrome characterized by marked analgesia and locomotor stimulation as well as tachycardia, tachypnoea and behavioural arousal. To determine whether other opiate receptors mediate some of the actions of the narcotic analgesics in the horse, an agent with activity at kappa- and to lesser extent mu-receptors was studied using a vigorous experimental protocol. Like fentanyl, ethylketazocine (EKC) (0.0025-0.012 mg kg-1 i.v.) produced marked dose-related analgesia to noxious thermal stimuli. Modest dose-related increases in locomotor activity, pupil diameter and rectal temperature were also observed. However, in contrast to fentanyl, EKC failed to produce any change in cardiac or respiratory rates and produced behavioural sedation rather than arousal. These data suggest that mu- and possibly kappa-receptors can mediate the actions of narcotics in the horse.

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Evaluation of Analgesic Drugs in Horses

Cited by 4 publications

References 16 publications

Evaluation of a microstrain gauge algesimeter for quantitative measurement of nociception in the dog

Evaluation of a microstrain gauge algesimeter for quantitative measurement of nociception in the dog

Initial Treatment of Colic

Dose-related effects of ethylketazocine on nociception, behaviour and autonomic responses in the horse

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