Evaluation of androgen receptor gene as a candidate gene in female androgenetic alopecia

El-Samahy, May H.; Shaheen, Maha Adel; Saddik, Dina E. B.; Fattah, Nermeen S. A. Abdel; El‐Sawi, Mohammad A.; Mahran, Manal Z.; Shehab, Abeer A. A.

doi:10.1111/j.1365-4632.2009.03991.x

Cited by 22 publications

(13 citation statements)

References 12 publications

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“…The search strategy retrieved 65 potentially relevant studies. Based on the inclusion criteria, only 8 studies 7,8,12,24–28 with full text were included in this meta‐analysis, thus 57 studies were excluded. These 8 selected case–control studies had enrolled a total of 2074 patients with AGA and 1115 healthy controls.…”

Section: Resultsmentioning

confidence: 99%

Androgen receptor gene polymorphisms and risk for androgenetic alopecia: a meta-analysis

Zhuo

Wang

et al. 2011

Clinical and Experimental Dermatology

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Section: Resultsmentioning

confidence: 99%

Androgen receptor gene polymorphisms and risk for androgenetic alopecia: a meta-analysis

Zhuo

Wang

et al. 2011

Clinical and Experimental Dermatology

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“…No relationship has been found between the presence of the StuI restriction fragment and FPHL. 81 However, just as in men, the number of CAG repeats in the first exon of the AR gene was inversely correlated with FPHL. 82 , 83 This observation allowed the development of genetic testing, in which the detection of a small number of CAG repeats is associated with an increased risk of development of FPHL, whereas a larger number of repeats is associated with a lower risk ( http://www.hairdx.com ).…”

Section: Geneticsmentioning

confidence: 93%

Female Pattern Hair Loss: a clinical and pathophysiological review

Ramos

Miot

2015

An. Bras. Dermatol.

154

161

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Female Pattern Hair Loss or female androgenetic alopecia is the main cause of hair loss in adult women and has a major impact on patients' quality of life. It evolves from the progressive miniaturization of follicles that lead to a subsequent decrease of the hair density, leading to a non-scarring diffuse alopecia, with characteristic clinical, dermoscopic and histological patterns. In spite of the high frequency of the disease and the relevance of its psychological impact, its pathogenesis is not yet fully understood, being influenced by genetic, hormonal and environmental factors. In addition, response to treatment is variable. In this article, authors discuss the main clinical, epidemiological and pathophysiological aspects of female pattern hair loss.

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“…Two other studies have investigated the association between the major M‐AGA susceptibility locus, the X‐chromosomal locus containing the androgen receptor ( AR ) and ectodysplasin A2 receptor ( EDA2R ) genes, and FPHL. These association studies, carried out in a very small Egyptian sample and the above‐mentioned sample of Chinese Han women with FPHL, were each limited to the investigation of the CAG repeat length variant of the AR gene and no association between this and FPHL was found . Fine mapping studies of this locus in AGA have indicated that the CAG repeat length variant is unlikely to be the causative variant and that other variants at this locus show much stronger association with AGA …”

Section: Heritable Factors—the Present Status Of Fphl Genetic Researchmentioning

confidence: 99%

Genetics and other factors in the aetiology of female pattern hair loss

Redler

Messenger

Betz

2017

Experimental Dermatology

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Pattern hair loss is the most common form of hair loss in both women and men. Male pattern hair loss, also termed male androgenetic alopecia (M-AGA), is an androgendependent trait that is predominantly genetically determined. Androgen-mediated mechanisms are probably involved in female pattern hair loss (FPHL) in some women but the evidence is less strong than in M-AGA; other non-androgenic pathways, including environmental influences, may contribute to the aetiology. Genome-wide association studies have identified several genetic loci for M-AGA and have provided better insight into the underlying biology. However, the role of heritable factors in and it has long been assumed that FPHL shares the same aetiology;hence, the term "female androgenetic alopecia" is often applied to this condition. However, the role of androgens in causing FPHL is less clear than in men. The genetic studies performed so far have not led to any firm conclusions but rather suggest different pathways for M-AGA and FPHL.In this review, we summarize what is known about the aetiology of FPHL and its relationship to M-AGA. Our main focus is on the results of genetic studies performed within the last decade. We also discuss the role of endocrine and other factors in the pathogenesis. | PREVALENCEPublished data on the prevalence of FPHL show some variation between studies, perhaps reflecting the difficulty in classifying mild forms of the condition. However, all show an increasing prevalence with age. Studies in women of white European ethnicity in the USA, [2] UK [3] and Australia [4] record a prevalence of 3%-12% in the third decade, rising to 14%-28% in the sixth decade and 29%-56%

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Evaluation of androgen receptor gene as a candidate gene in female androgenetic alopecia

Abstract: In contrast with male AGA, no association was found between type II AGA in Egyptian women and the AR gene. Therefore, the genetic study of this gene does not serve as a biomarker for the identification of women with a predisposition to AGA.

Cited by 22 publications

References 12 publications

Androgen receptor gene polymorphisms and risk for androgenetic alopecia: a meta-analysis

Androgen receptor gene polymorphisms and risk for androgenetic alopecia: a meta-analysis

Female Pattern Hair Loss: a clinical and pathophysiological review

Genetics and other factors in the aetiology of female pattern hair loss

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