Evaluation of angiotensin converting enzyme gene polymorphism and susceptibility to bronchial asthma among Egyptians

Elshafei, Maha; Farres, Mohamed Nazmy; Shahin, Rasha Y

doi:10.1016/j.aller.2011.05.010

Cited by 9 publications

(5 citation statements)

References 26 publications

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“…Considering that it has been suggested that the deviation from the expected genotypic frequencies based on the HWE may be a sign of genotyping error [2], I think that during genotyping some kinds of errors occurred. My suggestion might be confirmed by comparison between the studies of Hassanin et al [1] with other reports from Egypt [3][4][5][6][7] on the prevalence of the D allele. It should be noted that the study of Hassanin et al [1] showed a higher prevalence of the D allele (and alternatively a lower prevalence of the I allele) compared with the other studies [3][4][5][6][7].…”

supporting

confidence: 64%

Hardy–Weinberg equilibrium and association study of insertion/deletion polymorphism of ACE gene and Alzheimer’s disease in Egyptian patients

Saadat

2014

Egyptian Journal of Medical Human Genetics

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supporting

confidence: 64%

Hardy–Weinberg equilibrium and association study of insertion/deletion polymorphism of ACE gene and Alzheimer’s disease in Egyptian patients

Saadat

2014

Egyptian Journal of Medical Human Genetics

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“…In the field of asthma, a large number of studies, mainly in Chinese, correlates the D allele with its pathogenesis (37,39,(104)(105)(106)(112)(113)(114), underpinning the fact that individuals carrying the DD genotype are at up to a 60% higher risk of asthma development (37). On the other hand, studies in South Korea, Egypt, Japan and Turkey agree that ACE I/D is not associated with asthma development (107)(108)(109)115), while within the Pakistani population the I allele unexpectedly appears to be a predisposing factor and the D allele a possible protective trait (111).…”

Section: Discussionmentioning

confidence: 99%

“…The majority of studies on the positive correlation between the ACE I/D variation and asthma pathogenesis come from China, while studies on populations from certain other countries appear to have produced contradicting results. More specifically, case-control studies on population samples from South Korea, Egypt and Japan conclude that this particular ACE polymorphism is not associated with asthma development (107)(108)(109). A relevant study in Turkey, in which researchers also measured enzyme activity in the participating subjects, did not show significant differences in allele distribution between patients and controls, but the ACE activity was significantly increased in patients with asthma (110).…”

Section: Asthma and Ace I/d Polymorphismmentioning

confidence: 99%

The Impact ofACEandACE2Gene Polymorphisms in Pulmonary Diseases Including COVID-19

Gintoni

Αδαμοπούλου

Yapijakis

2021

In Vivo

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Chronic and acute respiratory diseases pose a major problem for public health worldwide due to the high morbidity and mortality rates, while treatment options remain mostly symptomatic. The renin-angiotensin system (RAS) plays an important role in lung tissue, regulating pulmonary circulation and blood pressure, but also contributing to normal pulmonary function and development. Angiotensin-converting enzyme (ACE) and its homologous angiotensin-converting enzyme 2 (ACE2) are considered to be amongst the main RAS regulators and are highly expressed in the pulmonary vascular endothelium. This review discusses the impact of ACE and ACE2 functional gene polymorphisms on seven major pulmonary diseases, in terms of predisposition, course, and outcome, revealing their potential utility as both genetic markers and biomarkers. The discussed conditions include chronic obstructive pulmonary disease (COPD), pulmonary hypertension (PH), asthma, acute lung injury (ALI), acute respiratory distress syndrome (ARDS), lung cancer and pulmonary sarcoidosis (PS), as well as SARS-CoV-2 viral infection and COVID-19 disease.Chronic respiratory diseases (CRDs) have been among the leading causes of morbidity and mortality around the globe for the last two decades (1-3). Their constantly increasing rates of occurrence may vary both between the genders, but also between different regions and socio-economic backgrounds (4). Nevertheless, the common denominator includes the deterioration of patients' quality of life that can often lead to several years of disability. The main CRDs are chronic obstructive pulmonary disease (COPD), pulmonary hypertension (PH), asthma and lung cancer, with COPD alone being the third leading cause of death worldwide, as reported in 2010 (1,5,6).On the other hand, acute lung diseases with an infectional etiology, pose a significant threat not only to lung health but also to human life (7). A recent great example is the 2019 outbreak of the novel coronavirus strain SARS-CoV-2 in China, causing the extremely infectious disease COVID-19, that led to a global pandemic and to millions of deaths, mainly due to severe respiratory complications (8, 9). So far, therapeutic approaches are mainly symptomatic, while knowledge on the exact pathogenetic mechanisms for complex lung-diseases remains limited. Consequently, prevention is predominantly based on general lifestyle guidelines, whereas the establishment of a priori personalized preventive measures, according to an individual's genetic predisposition, is still in its infancy (1, 5). Nevertheless, there are important known genetic markers that may be utilized for their predictive value.The renin-angiotensin system (RAS), in addition to its great importance for the overall homeostasis of the body, through the regulation of blood pressure and electrolyte balance, has a strong tissue-specific expression in the respiratory tract and functions both autonomously and 13 This article is freely accessible online.

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“…On the other hand, some studies failed to establish any associations of ACE gene polymorphisms with BA. For instance, ACE gene polymorphism is not significantly associated with BA or with its severity among Egyptian adults [39]. Similarly, the ACE genotype frequencies also do not significantly differ between the patients with BA and healthy controls in study conducted in Turkey [40], Iran [41], and Japan [42].…”

Section: Introductionmentioning

confidence: 84%

Bronchial Asthma: Genetic Factors Contributing to its Pathogenesis

Krynytska

Mykolenko

Smachylo

et al. 2021

Open Access Maced J Med Sci

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Researching bronchial asthma (BA)-linked gene polymorphisms can help to clarify heterogeneity of the disease and estimate its severity, which, in turn, will aid in developing an appropriate treatment corresponding to the patient’s unique asthma pathogenesis. The aim of presented review is to analyze the published data on the genetic preconditions of BA and the possible role of different genes polymorphisms in its pathogenesis. We have found that despite the fact that numerous genes are involved in the pathogenesis of BA and their polymorphisms are associated with increased risks for BA, it is important to understand that a combination of factors, both genetic and environmental, triggers BA development and determines its progression. On the other hand, the identification of BA susceptibility genes contributing to asthma pathogenesis and treatment response is the first step toward the development of personalized medicine.

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Evaluation of angiotensin converting enzyme gene polymorphism and susceptibility to bronchial asthma among Egyptians

Abstract: The results of our study indicate that ACE gene polymorphism is not significantly associated with bronchial asthma or with its severity among Egyptian adults.

Cited by 9 publications

References 26 publications

Hardy–Weinberg equilibrium and association study of insertion/deletion polymorphism of ACE gene and Alzheimer’s disease in Egyptian patients

Hardy–Weinberg equilibrium and association study of insertion/deletion polymorphism of ACE gene and Alzheimer’s disease in Egyptian patients

The Impact ofACEandACE2Gene Polymorphisms in Pulmonary Diseases Including COVID-19

Bronchial Asthma: Genetic Factors Contributing to its Pathogenesis

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