Evaluation of anthelmintic efficacy of Dryopteris kirbi infusion in West African Dwarf Goats, Western highlands of Cameroon

Tumasang, Thomas Tebug; Awah, Ndukum Julius; Vemo, Bertin Narcisse; Meutchieye, Félix; Kenmogne, Marc Kouam

doi:10.15739/ibspr.22.001

Cited by 2 publications

(4 citation statements)

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“…Our isolation and characterization of a new fructofuranosyl glycerol, 2-O-(2'-O-methyl-α-D-fructofuranosyl) glycerol (1), along with thirteen known compounds (2)(3)(4)(5)(6)(7)(8)(9)(10)(11)(12)(13)(14), as well as their cytotoxic and antibacterial activities, demonstrated the capacity of using the hexane-soluble portion, the main fraction EAF A from CC of the AcOEt-soluble portion, and the acylphloroglucinols aspidinols B and P (6 and 5) from D. kirbi as potent candidates in drug discovery to fight against human lung, breast, and cervical cancers and Gram-positive bacterial infections.…”

Section: Discussionmentioning

confidence: 99%

“…The ethnomedicinal use of wild plants by the people of Wabane, in the Southwest Region of Cameroon, indicated the efficacy of extracts from macerated D. kirbi rhizomes for the treatment of worms and hemorrhoids [2] . The anthelmintic efficacy of a D. kirbi hot water infusion was also recently reported [3] . To the best of our knowledge, phytochemical investigations of this plant species have not been performed.…”

Section: Introductionmentioning

confidence: 92%

“…[2] The anthelmintic efficacy of a D. kirbi hot water infusion was also recently reported. [3] To the best of our knowledge, phytochemical investigations of this plant species have not been performed. As part of our continuing search for bioactive constituents from the medicinal plants in Cameroon, [4] a new fructofuranoside glycerol (1), along with thirteen known compounds (2)(3)(4)(5)(6)(7)(8)(9)(10)(11)(12)(13)(14), was isolated from the hexane-, AcOEt-, and BuOH-soluble portions of the MeOH crude extract of D. kirbi rhizomes.…”

Section: Introductionmentioning

confidence: 99%

“…[3] To the best of our knowledge, phytochemical investigations of this plant species have not been performed. As part of our continuing search for bioactive constituents from the medicinal plants in Cameroon, [4] a new fructofuranoside glycerol (1), along with thirteen known compounds (2)(3)(4)(5)(6)(7)(8)(9)(10)(11)(12)(13)(14), was isolated from the hexane-, AcOEt-, and BuOH-soluble portions of the MeOH crude extract of D. kirbi rhizomes. Herein, we report the isolation and characterization of 1, as well as the cytotoxic and antibacterial activities of the extract, solventsoluble portions, main fractions from column chromatography (CC), and isolated compounds (1)(2)(3)(4)(5)(6)(7)(8)(9)(10)(11).…”

Section: Introductionmentioning

confidence: 99%

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Dryoptkirbioside, A New Fructofuranoside Glycerol, and Other Constituents from Dryopteris kirbi Hook et Grav Rhizomes

Matchide,

Hnin,

Nguekeu

et al. 2023

Chemistry & Biodiversity

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A new fructofuranoside glycerol, dryoptkirbioside (1), along with fourteen known compounds (2‐15), was isolated from the MeOH extract of Dryopteris kirbi rhizomes by silica gel column chromatography, Sephadex LH‐20 column chromatography, and semipreparative HPLC. The structure of the new compound was determined by analyses of its spectroscopic data including nuclear magnetic resonance (NMR), and high‐resolution electrospray ionisation mass spectrometry (HRESI‐MS) and chemical conversions. The n‐hexane‐soluble portion and the EAFA fraction showed strong activities against lung (A549), breast (MCF‐7), and cervical (HeLa) human cancer cell lines (IC50 values ranging from 4.0 to 8.8 µg/mL). Aspidinol P (5) and aspidinol B (6) exhibited moderate to low cytotoxicity on the three cell lines (IC50 values ranging from 20.4 to 58.7 µM). The MeOH extract and n‐hexane‐soluble portion had excellent activities against Staphylococcus aureus and Bacillus subtilis (MICs 11.7 and 23.4 µg/mL), whereas the EtOAc‐ and n‐BuOH‐soluble portions were significantly active on S. aureus (MICs 46.9 and 93.8 µg/mL). The main fractions EAFB, EAFC and nBFB displayed excellent activity against S. aureus (MICs 11.7 and 23.4 µg/mL). Aspidinol B (6) had significant activity, while aspidinol P (5) was moderately active against S. aureus and B. subtilis (MICs 42.0 and 89.5 µM).

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 92%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Dryoptkirbioside, A New Fructofuranoside Glycerol, and Other Constituents from Dryopteris kirbi Hook et Grav Rhizomes

Matchide,

Hnin,

Nguekeu

et al. 2023

Chemistry & Biodiversity

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Ethnoveterinary Practices: A Review of Phytotherapeutical Approaches in the Treatment of Livestock in Africa: Case of Cameroon

Tebug

Julius

Niba

et al. 2023

Int. J. Res. Granthaalayah

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Livestock health is a vital production factor in all production units. In the developed world, a lot of resources are invested in preventive measures unlike in the developing countries where resources are geared toward curative methods of livestock health care. Smallholder livestock production is an important sector of Cameroon’s economy, therefore for a sustainable production there should be a good livestock health care system. In Cameroon, livestock production is entrusted to poor, old and illiterate’s farmers with their indigenous methods of keeping livestock healthy and productive. For Cameroon to increase production, ethno veterinary medicine, which is adapted and affordable to smallholder breeders, should be developed for a sustainable smallholder production. Over 90% of the materials used in ethno veterinary medicine are from plants, hence there is an urgent need to conserve and propagate the medicinal plants already identified for fear of extinction due to random harvesting. Since ethno veterinary plants will be continuously used by smallholder livestock producers, there is a need to development ethno veterinary gardens for a sustainable use and conservation of these plants’ species for future generations. More research is needed to evaluate and validate the ethno veterinary properties of these plants’ preparations through collaboration between the ethno veterinary practitioners and researchers.

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Evaluation of anthelmintic efficacy of Dryopteris kirbi infusion in West African Dwarf Goats, Western highlands of Cameroon

Cited by 2 publications

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Dryoptkirbioside, A New Fructofuranoside Glycerol, and Other Constituents from Dryopteris kirbi Hook et Grav Rhizomes

Dryoptkirbioside, A New Fructofuranoside Glycerol, and Other Constituents from Dryopteris kirbi Hook et Grav Rhizomes

Ethnoveterinary Practices: A Review of Phytotherapeutical Approaches in the Treatment of Livestock in Africa: Case of Cameroon

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