Evaluation of anthropometry as an alternative to DXA as predictor of low bone mineral density in children and adolescents with cystic fibrosis

Júnior, Celso Costa da Silva; Queiroz, Dayanna Joyce Marques; Paiva, Maria Paula de; Lopes, Marina; Costa, Manoel da Cunha; Bezerra, Patrícia Gomes de Matos; Costa, Maria José de Carvalho; Silva, Alexandre; Filho, João Aragão Ximenes; Cartaxo, Constantino Giovanni Braga; Gonçalves, Maria da Conceição Rodrigues

doi:10.1016/j.clnesp.2021.08.020

Cited by 2 publications

(1 citation statement)

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“…The missed screening may result in an under diagnosis of cystic fibrosis bone disease, which may explain the decreased incidence of bone disease reported in the 2019 CFFPR report [ 8 ]. There is a need to identify better biomarkers and scores to stratify the patients in terms of the risk of bone disease and low impact fractures [ 159 ]. Perhaps the monitorization of the inflammatory status may predict the risk of low bone mass as the levels of C-reactive proteins negatively associated with the levels of procollagen type 1 N -terminal propeptide (P1NP) [ 147 ].…”

Section: Challenges In the Management Of Bone Health In Cystic Fibrosismentioning

confidence: 99%

Cystic Fibrosis Bone Disease: The Interplay between CFTR Dysfunction and Chronic Inflammation

et al. 2023

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Cystic fibrosis is a monogenic disease with a multisystemic phenotype, ranging from predisposition to chronic lung infection and inflammation to reduced bone mass. The exact mechanisms unbalancing the maintenance of an optimal bone mass in cystic fibrosis patients remain unknown. Multiple factors may contribute to severe bone mass reduction that, in turn, have devastating consequences in the patients’ quality of life and longevity. Here, we will review the existing evidence linking the CFTR dysfunction and cell-intrinsic bone defects. Additionally, we will also address how the proinflammatory environment due to CFTR dysfunction in immune cells and chronic infection impairs the maintenance of an adequate bone mass in CF patients.

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Section: Challenges In the Management Of Bone Health In Cystic Fibrosismentioning

confidence: 99%