Evaluation of anti‐bacterial activity of silver nanoparticles synthesised by coprophilous fungus PM0651419

Abstract

The study explored biological synthesis of metallic silver nanoparticles (AgNPs) from the less explored nonpathogenic coprophilous fungus, sterile mycelium, PM0651419 and evaluates the antimicrobial efficacy of biosynthesised AgNPs when impregnated in wound fabrics and in combination with six antimicrobial agents. AgNPs alone proved to be potent antibacterial agents and in combination they enhanced the antibacterial activity and spectrum of antibacterials used in the study against a microbiologically diverse battery of Gram positive, Gram negative and multidrug-resistant bacteria. AgNPs impregnated on the wound dressings established their antibacterial activity by significantly reducing the bacterial load of pathogenic bacteria like Staphylococcus aureus and Bacillus subtilis establishing potential as effective antimicrobial wound dressings for treatment of polymicrobial wound infections. This study presents the first report on the potential of biosynthesis of AgNPs from the under explored class of coprophilous fungi. Their promise to be used in wound dressings and as potent antibacterials alone and in combination is evaluated

Biosynthesis and antibiotic activity of silver nanoparticles using different sources: Glass industrial sewage‐adapted Bacillus sp. and herbaceous Amaranthus sp

“…Microbial-derived AgNPs biosynthesis is gaining attention as an environmentally friendly approach of AgNP synthesis without the need for hazardous chemicals and harsh treatment conditions [9]. Amongst microorganisms, bacteria growing in heavy metals-polluted area might have evolved types of mechanisms to tolerate metal-stressed conditions based on their long and continuous interactions with metal ions, leading to reduction of toxic heavy metal ions to a less toxic state [10].…”

“…Various living systems such as fungi [9], bacteria [1], and plants [24] have been utilized to create AgNPs. The finding of this study demonstrated that a bacterial cell, identified as FUM1 belonging to Bacillus sp., isolated from the sewage of a glass industrial unit fabricated AgNPs from Ag ions.…”

Myconanotechnology in veterinary sector: Status quo and future perspectives

“…The extracellular biosynthesis of silver NPs was studied using the algicolous endophytic fungus Penicillium polonicum which was isolated from marine algae and proved to have efficient antibacterial properties against biofilm forming, and multidrug resistant Acinetobacter baumannii [46]. In addition, a study was conducted in 2018 representing the 1st report on the potential of biosynthesized silver NPs from coprophilous fungi, to be used in wound dressings and as a potent antibacterial alone and in combination [47]. Another study took place recently displaying the capability of silver Nps biosynthesis by the fungus Trichoderma harzianum as a safe fungus for human and animals [48].…”

Facile Synthesis and Characterization of Cupric Oxide Loaded 2D Structure Graphitic Carbon Nitride (g-C3N4) Nanocomposite: In Vitro Anti-Bacterial and Fungal Interaction Studies

“…Additionally, CuO nanoparticles have recently been used in biomedical and cancer applications owing to their attractive chemical properties. Currently, one of the most attractive and active metals is copper, which has a long history in biological chemistry [ 8 , 9 ]. CuO nanoparticles showed excellent antimicrobial activity against different bacterial strains.…”