Evaluation of Anti-diabetic Activity of Isolated Fractions of Aegle Marmelos

Abstract

The aim of this study was to evaluate the anti-diabetic activity of isolated fractions from Aegle marmelos. To achieve this, experiments were conducted on rats with induced diabetes using STZ. The isolated fractions were administered to the rats at different doses, specifically 20 mg/kg and 40 mg/kg, over duration of 28 days. Using the accu-chek active test meter, blood glucose levels were measured to assess the anti-diabetic effects of the isolated fractions. Additionally, a comparison was made with the standard anti-diabetic medication, pioglitazone, which was given to another group of rats at a normal dose of 2.7 mg/kg. The results of this study indicated that the isolated fractions of Aegle marmelos exhibited considerable anti-diabetic activity. Furthermore, the study also included acute and sub-acute toxicology assessments to determine the safety of the isolated fractions at higher doses. The acute toxic study demonstrated that Aegle marmelos was photochemically safe up to 300 mg/kg, while the sub-acute toxic study showed safety up to 1000 mg/kg. Overall, these findings suggest that the isolated fractions of Aegle marmelos have promising anti- diabetic potential, making them worthy candidates for further investigation and potential therapeutic applications.