Evaluation of anti-diabetic and anti-tumoral activities of bioactive compounds from Phoenix dactylifera L’s leaf: In vitro and in vivo approach

Chakroun, Mouna; Khemakhem, Bassem; Mabrouk, Hazem Ben; Abed, Hanen El; Makni, Mohamed; Bouaziz, Mohamed; Drira, Noureddine; Marrakchi, Naziha; Mejdoub, Hafedh

doi:10.1016/j.biopha.2016.09.062

Cited by 43 publications

(16 citation statements)

References 34 publications

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“…Active compounds in dates such as flavonoids, steroids, phenolics and saponins besides function as antidotes to free radicals also act as anti-diabetic [18]. Dates can inhibit glucose absorption through the carbohydrate hydrolysis inhibitor enzymes such as α-glucosidase and α-amylase [19]. Hyperglycemia due to impaired of insulin secretion will inhibit α-glycosidase and α-amylase inhibitors which controlled blood glucose levels in type 2 diabetes mellitus.…”

Section: Resultsmentioning

confidence: 99%

Effects of dates (Phoenix Dactylifera Linn) on Blood Glucose Levels in Type-2 Diabetes Mellitus Patients

Wijayanti¹,

Pamungkasari²,

Sugiarto³

2019

Proceedings of the Proceedings of the 1st Seminar and Workshop on Research Design, for Education, Social Science, Arts, and Hum

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Type-2 diabetes mellitus (DM) burdens health care costs when complications occurred. Dates (Phoenix dactylifera Linn) contain almost complete nutrients, fiber and rich in antioxidants, which can control blood glucose levels. This study aimed to determine the effect of dates on blood glucose levels. This was the experimental study with Randomized Control Trial Pretest and Posttest. There were 36 outpatients of type-2 DM, divided into two groups, control and treatment. 50 grams of Lulu dates were given to the treatment group a day, while the control group were not. In 14 days, all groups were continued to consume oral anti-diabetic drugs. Daily intake data were obtained from 24-hr recall questionnaires, nutritional status data obtained from anthropometric measurements while data of DM from blood glucose levels. Data analysis using the Paired t-test. Results showed that the difference in the decrease of blood glucose levels, in control group (8.67 mg/dl, p-value=0.067) were lower than the treatment group (22.94 mg/dl, p-value=0.04). There were no significant decrease of blood glucose levels between control and treatment groups (p-value=0.223). In this study, consumption of dates has no significant effect on blood glucose levels, but further study are needed to know how dates can improve blood glucose levels.

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Section: Resultsmentioning

confidence: 99%

Effects of dates (Phoenix Dactylifera Linn) on Blood Glucose Levels in Type-2 Diabetes Mellitus Patients

Wijayanti¹,

Pamungkasari²,

Sugiarto³

2019

Proceedings of the Proceedings of the 1st Seminar and Workshop on Research Design, for Education, Social Science, Arts, and Hum

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“…The result of evaluation confirmed the ethnopharmacological significance of the plant and could be taken further for the development of an effective pharmaceutical drug against diabetes. 19 …”

Section: Araliaceaementioning

confidence: 99%

“…Blighia sapida: Two hypoglycemic principles called hypoglycin A (19) and B (20) were isolated from the fruits of B. sapida. Of these two compounds, hypoglycin A was twice as active as hypoglycin B.…”

Section: Sapindaceaementioning

confidence: 99%

A Review on Anti-diabetic Plants

Qais

Jahan

Shajib

2018

Dhaka Univ. J. Pharm. Sci

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Diabetes mellitus is a common metabolic disorder whose prevalence is rapidly increasing all over the world. According to WHO, diabetes will be the seventh leading cause of death in 2030. Since long back, plants have been used to heal or combat illness and are the source of many modern medicines. In view of the above aspects, the present review provides information about the antidiabetic plants, available through literature source from various database. From the present study it is evident that most of the plants having anti-diabetic properties belong to the family Moraceae, Cucurbitaceae, Liliaceae, Anacardiaceae, Myrtaceae, Fabaceae, Solanaceae, Asteraceae and many others. The hypoglycemic activities are contained in different parts of these plants like leaf, rhizomes, fruits, bark, seeds or other parts which differ from species to species. It is also evident from this review that the mode of action and dosage of administration differs from plant to plant.

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“…The product was purified by column chromatography using CHCl 3 2-Nitrobenzofuran 8 was prepared from the diacetate of salicylic alcohol 4c and potassium trinitromethanide 7. Solution obtained was cooled and poured into water; the formed solid was filtered off, washed with water, and dried.…”

Section: (12-dihydronaphtho[21-b]furan-2yl)(4-hydroxyphenyl)methamentioning

confidence: 99%

Synthesis and biological evaluation of 2‐acylbenzofuranes as novel α‐glucosidase inhibitors with hypoglycemic activity

et al. 2017

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A series of benzofuran derivatives was synthesized as analogues of known natural α-glucosidase inhibitors. Their activity was evaluated in enzymatic assay and in rat model of diabetes mellitus. Newly identified inhibitors demonstrate significant potency with IC values ranging from 6.50 to 722.2 μm, as well as hypoglycemic activity exceeding the reference drug acarbose. Docking simulations provided insight into structure-activity relationships to direct further development of these novel hypoglycemic agents.

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Evaluation of anti-diabetic and anti-tumoral activities of bioactive compounds from Phoenix dactylifera L’s leaf: In vitro and in vivo approach

Cited by 43 publications

References 34 publications

Effects of dates (Phoenix Dactylifera Linn) on Blood Glucose Levels in Type-2 Diabetes Mellitus Patients

Effects of dates (Phoenix Dactylifera Linn) on Blood Glucose Levels in Type-2 Diabetes Mellitus Patients

A Review on Anti-diabetic Plants

Synthesis and biological evaluation of 2‐acylbenzofuranes as novel α‐glucosidase inhibitors with hypoglycemic activity

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