Evaluation of anti-epileptic property of<i>Marsilea quadrifolia</i>Linn. in maximal electroshock and pentylenetetrazole-induced rat models of epilepsy

“…The time taken for the onset of myoclonic jerk, seizures and duration of seizures was recorded. 23,25 Chronic study Four groups of rats with 6 animals in each were used. All drugs (as mentioned in acute study) were administered once a day between 15:00 and 17:00 hours for 6 weeks prior to the administration of PTZ (60 mg/kg, i.p.)…”

Section: Acute Studymentioning

confidence: 99%

Evaluation of effect of aqueous extract of leaves of Calotropis procera in pentylenetetrazole induced seizures in rats

Ramachandra

Shenoy

Madhyastha

et al. 2016

Int J Basic Clin Pharmacol

View full text Add to dashboard Cite

“…The plant extracts exhibit antibacterial [ 196 , 198 , 199 , 200 ], antidiarrheal [ 194 ], antifungal [ 201 ], analgesic [ 194 ], anti-inflammatory [ 202 ], antioxidant [ 203 , 204 ], antidiabetic [ 205 ], anti-Alzheimer's [ 206 , 207 ], antiepileptic [ 208 ], anticonvulsive [ 209 ], nephroprotective [ 210 ] and antitumor [ 211 ] activities.…”

Section: Distribution Ethnomedicine Pharmacognosy and Phytochemistry ...mentioning

confidence: 99%

A comprehensive review on Nepalese wild vegetable food ferns

Bajracharya

Bajracharya²

2022

Heliyon

View full text Add to dashboard Cite

“…8 If extension of the hind limb was not more than 90 degree angle with the plane of the body, then the tonic component was considered to be abolished. [10][11][12] Acute study…”

Section: Maximal Electroshock (Mes) Induced Seizure Modelmentioning

confidence: 99%

A study of effect of acute and chronic administration of aqueous extract of Calotropis procera leaves on maximal electroshock induced seizures in rats

Madhyastha

Shenoy

Ramachandra

et al. 2017

Int J Basic Clin Pharmacol

View full text Add to dashboard Cite

INTRODUCTION Epilepsy is characterized by seizures which is due to excessive, abnormal and asynchronous neuronal activity in the brain. 1 Though many antiepileptic drugs are ABSTRACT Background: The effect of acute and chronic administration of aqueous extract of leaves of Calotropis procera on maximal electroshock (MES) induced seizures in rats was evaluated. Methods: Four groups of wistar rats were treated with distilled water 10 mL/kg (oral), phenytoin 25 mg/kg (intraperitoneal), 250mg/kg (oral) and 500mg/kg (oral) of aqueous extract of leaves of C procera, respectively in both acute and chronic studies. For producing maximal electroshock seizures, an electroconvulsiometer was used to deliver an electric stimulus of 150mA for 0.2 sec. The duration of hind limb extension (HLE) and seizures were noted in seconds (sec). In the acute study, the shock was given 1 h after administration of drugs. For the chronic study, all drugs were administered for 6 weeks. One hour after the last dose of drugs, the shock was administered. Data was analyzed by one way ANOVA followed by Tukey's post hoc test. Results: There was a significant decrease in the duration of hind limb extension, and convulsions as compared to control following acute (p<0.01 vs control) and chronic (p<0.05 vs control) administration of aqueous extract of leaves of Calotropis procera in rats. Conclusions: The study demonstrated that aqueous extract of C procera leaves resulted in significant protection against maximal electroshock induced seizures in rats.

show abstract

Evaluation of anti-epileptic property ofMarsilea quadrifoliaLinn. in maximal electroshock and pentylenetetrazole-induced rat models of epilepsy

Abstract: Marsilea quadrifolia Linn. showed significant anti-epileptic efficacy against various epilepsy models.

Cited by 9 publications

References 23 publications

Evaluation of effect of aqueous extract of leaves of Calotropis procera in pentylenetetrazole induced seizures in rats

Evaluation of effect of aqueous extract of leaves of Calotropis procera in pentylenetetrazole induced seizures in rats

A comprehensive review on Nepalese wild vegetable food ferns

A study of effect of acute and chronic administration of aqueous extract of Calotropis procera leaves on maximal electroshock induced seizures in rats

Contact Info

Product

Resources

About