Evaluation of anti-hyperglycemic and hypoglycemic effect of Trigonella foenum-graecum Linn, Ocimum sanctum Linn and Pterocarpus marsupium Linn in normal and alloxanized diabetic rats

Vats, Vikrant; Grover, J.K; Rathi, Satyajeet S.

doi:10.1016/s0378-8741(01)00374-9

Cited by 239 publications

(136 citation statements)

References 9 publications

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“…In the present study, IA restored the depressed hepatic glycogen levels possibly by increasing insulin ( Figure 7). Decreased activities of the enzymes involved in glucose homeostasis in liver and kidney such as hexokinase has been reported in diabetic animal resulting in depletion of liver and muscle glycogen content 19 . Based on present study, the plant extract of Ipomoea aquatica possesses antibacterial, blood glucose and lipid lowering activities.…”

Section: Discussionmentioning

confidence: 99%

Antibacterial, Antidiabetic and Lipid Lowering Effects of Ethanolic Extract of Ipomoea aquatica

Khatun

Islam

Azad

et al. 2016

Bangla. J. Microbiol.

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Present study was designed to investigate antibacterial, antidiabetic and lipid lowering effects of ethanolic leaf extract of Ipomoea aquatica (IA). The antibacterial effect of IA leaf extract was performed using agar-cup-diffusion assay against six pathogenic bacterial strains such as Klebsiella aerogenes, Escherichia coli, Staphylococcus aureus and Bacillus cereus Vibrio cholerae and Salmonella typhi. This extract has potent antibacterial effect against all six strains compared to commercially available antibiotics of cetriaxone, ciprofloxacin and ampicillin. Total of 40 Swiss Albino male mice were used for investigation of antidiabetic and lipid lowering effects and made diabetic by alloxan. 20 mice were used for oral glucose tolerance test (OGTT) and 20 mice for a week-long anti-hyperglycemic. Both groups were subdivided into four, each having 5 mice- i) the control receive only 0.5% methyl cellulose as vehicle; ii) Standard received vehicle plus metformin; iii & iv) test samples DIA 250 and DIA 500 received vehicle plus IA extract with 250 and 500 mg /kg b. wt (body weight), respectively. Lipid profile analysis was performed by estimating total cholesterol (TC), triglyceride (TG) and liver glycogen concentration on 20 mice after week-long antihyperglycemic tested mice. The glucose tolerance results showed significant (p<0.05) and improved 50.03% and 66.09% at the DIA250 and DIA500, respectively. However, IA significantly reduced (p<0.05) blood glucose level 57.89% and 69.12% at the DIA250 and DIA500, respectively for a weeklong anti-hyperglycemic activity. Both glucose tolerance and hypoglycemic effect is comparable to diabetic control group and the effect is dose dependent. In addition to anti-hyperglycemic effect, alloxan induced diabetic mice showed increase in plasma TC and TG level. After the administration of IA extract, TC and TG level were restored to near normal level which showed significant (p<0.05) results. The results of IA extract also showed significant (p<0.05) and improved liver glycogen content compared to diabetic control mice group. These results indicate that IA has antibacterial, antidiabetic and lipid lowering effects.Bangladesh J Microbiol, Volume 29, Number 2, Dec 2012, pp 50-54

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Section: Discussionmentioning

confidence: 99%

Antibacterial, Antidiabetic and Lipid Lowering Effects of Ethanolic Extract of Ipomoea aquatica

Khatun

Islam

Azad

et al. 2016

Bangla. J. Microbiol.

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“…Isolated studies screened various plants having "folk medicine reputation" by biochemical test for this antidiabetogenic effect (Vats et al, 2002).…”

Section: Introductionmentioning

confidence: 99%

Alteration of Dentate Gyrus Astrocytes in Diabetic Rats: Protective Role of Urtica dioica

et al. 2011

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GOLALIPOUR, M. J.; GHAFARI, S.; LATIFIMOGHADAM, M. H. & KABOLI, S.Alteration of dentate gyrus astrocytes in diabetic rats: Protective role of Urtica dioica. Int. J. Morphol., 29(4):1307-1312, 2011. SUMMARY:Diabetes mellitus can cause astrocytes alterations in the central nervous system. Urtica dioica (Nettle) is among several species listed for their use against diabetes in folk medicine. Therefore, this study was done to evaluate the protective effect of Urtica dioica on astrocytes density of the dentate gyrus in STZ induced diabetic rats. In this experimental study, 21 male albino Wistar rats were randomly allocated equally into normal, diabetic and protective (nettle treated diabetic) groups. Hyperglycemia was induced by streptozotocin (80 mg/kg) in the animals of diabetic and treatment groups. Before induction of diabetes in animals, animals in protective group received hydroalcoholic extract of Urtica dioica (100 mg/kg/BW /day) for five days intraperitoneally. Four weeks after induction of diabetes, animals were sacrificed and coronal sections were taken from the dorsal hippocampal formation of the right cerebral hemispheres and stained with PTAH stain. The area densities of the astrocytes were measured and compared in the three groups (p < 0.05). The number of astrocytes in DG area of controls was 17.72±6.7. The density of astrocytes increased in diabetic (24.26±9.5) in comparison with controls. The density in the nettle treated rats (23.17±5.8) was lower than diabetic rats. This study showed that the administration of U. dioica extract before induction of diabetes can not significantly help compensate for astrocytes in the dentate gyrus of treated rats.

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“…Diabetes mellitus is a major cause of disability and hospitalization and it results in significant financial burden (Vats et al, 2002). By the year 2010, the total number of people worldwide with diabetes mellitus is projected to reach 239 million.…”

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confidence: 99%

Antidiabetic effect of <i>Ceiba pentandra</i> extract on streptozo-tocin-induced non-insulin-dependent diabetic (niddm) rats

Dzeufiet

Ohandja²,

Tedong³

et al. 2007

Afr. J. Trad. Compl. Alt. Med.

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The aim of this work was to investigate the effect of daily oral administration of root bark methylene chloride/methanol extract of Ceiba pentandra (Linn) in streptozotocin-induced type-2 diabetic rats, and the effect of this treatment on the physiological and metabolic parameters that are related in diabetic animals. The diabetic rats were separated into four groups and each given the following samples by gavage, daily for 28 days: vehicle (diabetic control), Ceiba pentandra extract at the dose of 40 mg/kg, Ceiba pentandra extract at the dose of 75 mg/kg and glibenclamide (5 mg/kg). All the parameters were also determined in healthy (non diabetic) rats for comparison. The methylene chloride/methanol extract of Ceiba pentandra treatment significantly reduced the intake of both food and water as well as the levels of blood glucose, serum cholesterol, triglyceride, creatinine and urea, in comparison with diabetic controls. The treatment also improves impaired glucose tolerance but no effect was observed in the level of hepatic glycogen. The effect of Ceiba pentandra (40 mg/kg) was more prominent when compared to glibenclamide in lowering blood glucose, with the added benefit of considerably reducing serum cholesterol and triglyceride concentrations. The results of this experimental animal study indicated that Ceiba pentandra possesses antidiabetic activity; and thus is capable of ameliorating hyperglycaemia in streptozotocin-induced type-2 diabetic rats and is a potential source for isolation of new orally active agent(s) for anti-diabetic therapy.

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Evaluation of anti-hyperglycemic and hypoglycemic effect of Trigonella foenum-graecum Linn, Ocimum sanctum Linn and Pterocarpus marsupium Linn in normal and alloxanized diabetic rats

Cited by 239 publications

References 9 publications

Antibacterial, Antidiabetic and Lipid Lowering Effects of Ethanolic Extract of Ipomoea aquatica

Antibacterial, Antidiabetic and Lipid Lowering Effects of Ethanolic Extract of Ipomoea aquatica

Alteration of Dentate Gyrus Astrocytes in Diabetic Rats: Protective Role of Urtica dioica

Antidiabetic effect of <i>Ceiba pentandra</i> extract on streptozo-tocin-induced non-insulin-dependent diabetic (niddm) rats

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