Evaluation of anti inflammatory activity of Indigofera aspalathoides Vahl in Swiss albino mice

Bhagavan, N. Boopala; Arunachalam, S.; Dhasarathan, P.; Kannan, Narayanan

doi:10.1016/j.jopr.2013.02.018

Cited by 7 publications

(4 citation statements)

References 12 publications

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“…However, its antioxidant capacity may contribute, at least in part, to reduce the mice ear edema. It is well known that oxidative stress is associated with inflammation development (Bhagavan et al 2013).…”

Section: Croton Oil-induced Ear Edema Testmentioning

confidence: 99%

“…Oxidative stress, several chemical mediators and cellular components are involved in the inflammatory response, playing essential roles in the physiopathology of various high prevalence diseases, including rheumatoid arthritis, atherosclerosis, and asthma (Bhagavan et al 2013). There is also evidence that oxidative stress is associated with neurotoxic mechanisms involved in the pathogenesis of neurodegenerative disorders (Neal & Richardson 2018).…”

Section: Introductionmentioning

confidence: 99%

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In vivo anti-inflammatory and antinociceptive effects, and in vitro antioxidant, antiglycant and anti-neuroinflammatory actions of Syzygium malaccense

Mendes

Bellozi

Conegundes

et al. 2021

An. Acad. Bras. Ciênc.

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Syzygium malaccense is popularly used to treat infl ammation and painrelated ailments. The species was assessed regarding its antioxidant, antiglycant, antiinfl ammatory, including anti-neuroinfl ammatory, and antinociceptive activities. Different models were employed to measure S. malaccense extract (ESM) antioxidant activity.The antiglycant activity was determined using the glucose-induced protein glycation model. LPS-induced neuroinfl ammation on murine BV-2 microglial cell line was used for anti-neuroinfl ammatory activity evaluation. The croton oil-induced ear edema test was accomplished to evaluate the in vivo anti-infl ammatory activity. Acetic acid-induced writhing together with formalin-induced paw licking assays were performed to evaluate the antinociceptive potential. Finally, the chemical characterization was accomplished by a UHPLC-MS analysis. ESM presented relevant antioxidant and antiglycant activity. NO production by BV-2 cells was reduced, indicating the relevant neuroprotective activity.ESM signifi cantly decreased the mice ear edema induced by croton oil and the nociceptive stimulus induced by acetic acid and formalin by central and peripheral mechanisms.The fl avonoids myricitrin, myricetin and quercetin were identifi ed and, as far as we know, the alkaloid reserpine was reported in the species for the fi rst time. The antioxidant and antiglycant potential of ESM, may be related to the in vivo anti-infl ammatory and antinociceptive effects, and to the in vitro neuroinfl ammation inhibition.

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Section: Croton Oil-induced Ear Edema Testmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

In vivo anti-inflammatory and antinociceptive effects, and in vitro antioxidant, antiglycant and anti-neuroinflammatory actions of Syzygium malaccense

Mendes

Bellozi

Conegundes

et al. 2021

An. Acad. Bras. Ciênc.

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“…While a larger number of investigations have been carried out in in vivo models. I. aspalathoides holds antioxidant, antibacterial, anti-inflammatory, anticancer, antihepatotoxic, antiarthritic, immunomodulatory, and antidiabetic properties (Abraham et al, 2010;Amala Bhaskar, Ganga, Arivudainambi, & Santhanam, 1982;Balasubramanian et al, 2007;Bhagavan, Arunachalam, Dhasarathan, & Kannan, 2013;Bhuvaneswari & Balasundaram, 2006;Christina et al, 2003;Claimer, Mahesh, Sinilal, Rao, & Thangadurai, 2012;S. S. Kumar, Karrunakaran, Rao, & Balasubramanian, 2010;T.…”

Section: Methodsmentioning

confidence: 99%

Bioactivities of extracts and phytochemicals of Indigofera aspalathoides Vahl ex DC.

2021

EJS

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Indigofera aspalathoides Vahl ex DC. belongs to the Fabaceae family. I. aspalathoides is applied to heal tumors, inflammations, diabetes, leprosy, and kidney illnesses in traditional medicines. Compounds including kaempferol, kaempferol 5-O-β-D-glucopyranoside, 5,4'-dihydroxy 6,8-dimethoxy 7-O-rhamnosyl flavone, indigocarpan, and mucronulatol have isolated from this plant species. Hitherto, there is no comprehensive review available regarding the reported bioactivities of I. aspalathoides. Thus, this article goals to analyze, summarize and document the published bioactivities-related publications. Electronic databases the Web of Science, Scopus, ScienceDirect, and PubMed used to find relevant publications from 1900 to December 2020. Thus far, only in vivo and in vitro scientific evidence levels of bioactivities are available. I. aspalathoides holds such as anti-inflammatory, anticancer, antihepatotoxic, anti-arthritic, immunomodulatory, and antidiabetic properties. Overall, immunomodulatory, anti-inflammatory, and anticancer compounds have been isolated from this plant species Therefore, additional bioactivity and phytochemical-related researches would need to perform to generate more scientific evidence for other applications. This work will be useful for further bioactivity and phytochemical studies using this plant species.

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“…[27] The flavone glycoside isolated from the stem of I. aspalathoides has cytotoxic activity against 57 human tumour cell lines, [28] and the anti-inflammatory property of the plant was studied and compared with standard indomethacin. [29] 2 | EXPERIMENTAL SECTION…”

Section: Introductionmentioning

confidence: 99%

Biofunctionalized silver and gold nanoparticles as potential curative agents

Velammal

Amaladhas

2020

Applied Organom Chemis

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In this study, the bark of an important medicinal plant, Indigofera aspalathoides is utilized as a bioreductant for the synthesis of silver nanoparticles (AgNPs) and gold nanoparticles (AuNPs). The formation of nanoparticles was monitored, and the reaction parameters were optimized by UV-Vis spectroscopy. The attachment of biocomponents as stabilizer was proved employing Fourier-transform infrared (FT-IR) studies. Through transmission electron microscopy (TEM), the morphology was found to be predominantly spherical and a mixture of triangle and hexagon in the case of AgNPs and AuNPs, respectively. The crystallite size of AgNPs and AuNPs was affirmed through X-ray diffraction (XRD) studies using Sherrer formula as 22.03 and 47.70 nm, respectively. DPPH method was adopted to analyse the freeradical quenching ability, and the AgNPs, AuNPs and extract showed inhibition of 76%, 89% and 59% at a concentration of 200 μg ml −1 , and the corresponding IC 50 values were 86.49, 55.20 and 149.19 μg ml −1. The binding of nanoparticles to calf-thymus DNA (CT-DNA) was through groove and the high binding constants (8.49 × 10 6 M −1 and 2.34 × 10 7 M −1 for AgNPs and AuNPs) point out the potential of these nanoparticles as curative drugs. The MTT assay showed that AgNPs were 100% toxic, and the low IC 50 value suggests that this can be used in the medicinal field as a safe drug.

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Evaluation of anti inflammatory activity of Indigofera aspalathoides Vahl in Swiss albino mice

Cited by 7 publications

References 12 publications

In vivo anti-inflammatory and antinociceptive effects, and in vitro antioxidant, antiglycant and anti-neuroinflammatory actions of Syzygium malaccense

In vivo anti-inflammatory and antinociceptive effects, and in vitro antioxidant, antiglycant and anti-neuroinflammatory actions of Syzygium malaccense

Bioactivities of extracts and phytochemicals of Indigofera aspalathoides Vahl ex DC.

Biofunctionalized silver and gold nanoparticles as potential curative agents

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