Evaluation of anti-inflammatory activity of Alstonia macrophylla Wall ex A. DC. leaf extract

Arunachalam, G.; Chattopadhyay, Debprasad; Chatterjee, Sumana; Mandal, Asit Baran; Sur, Tapas Kumar; Mandal, Subhash C.

doi:10.1078/094471102321616445

Cited by 24 publications

(28 citation statements)

References 10 publications

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“…A part of the residue was stored in a dessicator for further study (Chattopadhyay et al, 2001(Chattopadhyay et al, , 2003(Chattopadhyay et al, , 2006. The phytochemical analysis (Trease and Evans, 1983;Arunachalam et al, 2002;Chattopadhyay et al, 2004) indicated the presence of tannins, flavonoids, triterpenoids, sterols, alkaloids and reducing sugars. The powdered residue (32 g) was then suspended in water and extracted with nbutanol.…”

Section: Extraction and Fractionationmentioning

confidence: 99%

“…Thirty minutes later, oedema was induced by subplantar injection of 0.05 ml of a freshly prepared carrageenan suspension (1% w/v) in normal saline into the right hind paw of each rat (Winter et al, 1962;Chattopadhyay et al, 2005b). The paw volume (linear circumference of the injected paw) was measured at 0 h and at 3 h after the injection of carrageenan, by a plethysmometer (Winter et al, 1962;Arunachalam et al, 2002). The animals were sacrificed 4 h after the subplantar injection; both the hind paws were severed from the ankle joints and weighed.…”

Section: Carrageenan-induced Rat Paw Oedemamentioning

confidence: 99%

“…The oedema was induced in the right hind paw by subplantar injection of 0.1ml of freshly prepared 1% dextran solution (Nunez-Guillen et al, 1997; Arunachalam et al, 2002;Chattopadhyay et al, 2005b). Paw volume was measured 30 min before and after dextran injection.…”

Section: Dextran-induced Rat Paw Oedemamentioning

confidence: 99%

“…On the eighth day, the animals were anaesthetized, the cotton pellets were removed surgically, made free from extraneous tissues, incubated at 37°C for 24 h and dried at 60°C to constant weight. The increase in the dry weight of the pellets was taken as measure of granuloma formation (Winter and Porter, 1957;Arunachalam et al, 2002).…”

Section: Dextran-induced Rat Paw Oedemamentioning

confidence: 99%

“…study with few such medicaments showed promising results (Chattopadhyay et al, 1998;Chattopadhyay et al, 2001;Arunachalam et al, 2002;Chattopadhyay et al, 2002). The Genus Ophiorrhiza, sister group of Rubioideae of the family Rubiaceae contain 47 species (Manen and Natali, 1996), of which O. infundibularis Balakr., O. mungos L, O. nicobarica Balakr.…”

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Evaluation of analgesic and antiinflammatory activity of Ophiorrhiza nicobarica, an ethnomedicine from Nicobar Islands, India

Chattopadhyay¹,

Das²,

Mandal³

et al. 2007

Oriental Pharmacy and Experimental Medicine

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SUMMARYThis study reports the analgesic, anti-inflammatory and membrane-stabilizing property of alcoholic extract of Ophiorrhiza nicobarica (ON), a wild herb, used as an anti-infective ethnomedicine of Nicobarese and Shompen tribes of Great Nicobar Island, India. We for the first time investigated the analgesic and antiinflammatory potential of this herb in acute, subacute and chronic model of inflammation in Swiss albino mice and Wistar albino rats, along with sheep RBC-induced sensitivity and membrane stabilization. The acetic acid induced writhing, tail flick and tail immersion tests are used as a model for evaluating analgesic activity; while the carrageenin-induced paw oedema was used as the model for acute inflammation, dextran-induced oedema as sub-acute and cotton-pellateinduced granuloma as chronic inflammatory model. The probable mode by which ON mediate its effect on inflammatory conditions was studied on sheep RBC-induced sensitivity and membrane stabilization. The in vitro results revealed that the ON extract possesses significant (P < 0.05) dose dependent analgesic and antiinflammatory activity at 200 and 300 mg/kg and its fractions at 50 mg/ kg, p.o. respectively, compared to the control groups. However, the extract failed to exhibit membrane-stabilizing property as it unable to reduce the level of haemolysis of RBC exposed to hypotonic solution. The acute toxicity studies of ON extract in rats and mice revealed that the extract was nontoxic even up to 3.0 g/kg body weight of the animals, with a high safety profile. We have isolated ursolic acid, β-sitosterol and harmaline respectively, from the bioactive part of the extract. The results indicated that the O. nicobarica is indeed beneficial in primary health care, and suggest that its anti-inflammatory activity may not be related to membrane-stabilization.

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Section: Extraction and Fractionationmentioning

confidence: 99%

Section: Carrageenan-induced Rat Paw Oedemamentioning

confidence: 99%

Section: Dextran-induced Rat Paw Oedemamentioning

confidence: 99%

Section: Dextran-induced Rat Paw Oedemamentioning

confidence: 99%

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Evaluation of analgesic and antiinflammatory activity of Ophiorrhiza nicobarica, an ethnomedicine from Nicobar Islands, India

Chattopadhyay¹,

Das²,

Mandal³

et al. 2007

Oriental Pharmacy and Experimental Medicine

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Synthesis and Characterization of New 1,2,4‐Triazolo[1,5‐a]pyridines That Extend the Life Span of Caenorhabiditis elegans via Their Anti‐Inflammatory/Antioxidant Effects

Mekheimer

Sayed

Ahmed

et al. 2015

Archiv der Pharmazie

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In the present study, we describe the synthesis of a new set of 1,2,4-triazolo[1,5-a]pyridines and their fused ring systems. The products were assayed for various types of biological activities like anti-inflammatory and antioxidative activity. Compounds 4c, 4f, 12a, 14, 16, and 19 were found to reduce carrageenan- and dextran-induced inflammation in rats. In addition, compounds 4f and 12a were found to have antioxidative radical scavenging activity. Furthermore, these compounds were tested in the model system Caenorhabiditis elegans and there increased heat stress resistance, reduced the formation of advanced glycation end products, and finally extended the life span.

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An extract of Stephania hernandifolia, an ethnomedicinal plant, inhibits herpes simplex virus 1 entry

et al. 2021

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Evaluation of anti-inflammatory activity of Alstonia macrophylla Wall ex A. DC. leaf extract

Cited by 24 publications

References 10 publications

Evaluation of analgesic and antiinflammatory activity of Ophiorrhiza nicobarica, an ethnomedicine from Nicobar Islands, India

Evaluation of analgesic and antiinflammatory activity of Ophiorrhiza nicobarica, an ethnomedicine from Nicobar Islands, India

Synthesis and Characterization of New 1,2,4‐Triazolo[1,5‐a]pyridines That Extend the Life Span of Caenorhabiditis elegans via Their Anti‐Inflammatory/Antioxidant Effects

An extract of Stephania hernandifolia, an ethnomedicinal plant, inhibits herpes simplex virus 1 entry

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