Evaluation of Anti-Inflammatory Activity of Ethanolic Extract of Cananga Odorata Lam in Experimental Animals

Maniyar,

doi:10.5455/2319-2003.ijbcp20150439

Cited by 6 publications

(8 citation statements)

References 7 publications

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“…Besides the in vitro studies mentioned above, the anti-inflammatory activity of C. odorata also had been evaluated in experimental animals recently. The ethanolic extract of C. odorata fruit was shown to exhibit significant anti-inflammatory activity in the carrageenan induced paw edema model of Wistar albino rats with LD 50 > 2000 mg/kg [ 44 ]. The acute oral toxicity study indicated that the ethanolic extract C. odorata fruit was more effective in inhibition of paw volume (62.9%) at dose of 100 mg/kg than aspirin with inhibition of 60.14% at dose of 300 mg/kg.…”

Section: Anti-inflammatory Propertiesmentioning

confidence: 99%

“…The acute oral toxicity study indicated that the ethanolic extract C. odorata fruit was more effective in inhibition of paw volume (62.9%) at dose of 100 mg/kg than aspirin with inhibition of 60.14% at dose of 300 mg/kg. Furthermore, the author of the study suggested that anti-inflammatory effect of the extract might be due to the presence of flavonoids and tannins which is responsible for inhibiting both cyclooxygenase and lipoxygenase pathway [ 44 ].…”

Section: Anti-inflammatory Propertiesmentioning

confidence: 99%

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Traditional Uses, Phytochemistry, and Bioactivities ofCananga odorata(Ylang-Ylang)

Tan

Lee

Yin

et al. 2015

Evidence-Based Complementary and Alternative Medicine

145

106

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Ylang-ylang (Cananga odorata Hook. F. & Thomson) is one of the plants that are exploited at a large scale for its essential oil which is an important raw material for the fragrance industry. The essential oils extracted via steam distillation from the plant have been used mainly in cosmetic industry but also in food industry. Traditionally, C. odorata is used to treat malaria, stomach ailments, asthma, gout, and rheumatism. The essential oils or ylang-ylang oil is used in aromatherapy and is believed to be effective in treating depression, high blood pressure, and anxiety. Many phytochemical studies have identified the constituents present in the essential oils of C. odorata. A wide range of chemical compounds including monoterpene, sesquiterpenes, and phenylpropanoids have been isolated from this plant. Recent studies have shown a wide variety of bioactivities exhibited by the essential oils and the extracts of C. odorata including antimicrobial, antibiofilm, anti-inflammatory, antivector, insect-repellent, antidiabetic, antifertility and antimelanogenesis activities. Thus, the present review summarizes the information concerning the traditional uses, phytochemistry, and biological activities of C. odorata. This review is aimed at demonstrating that C. odorata not only is an important raw material for perfume industry but also considered as a prospective useful plant to agriculture and medicine.

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Section: Anti-inflammatory Propertiesmentioning

confidence: 99%

Section: Anti-inflammatory Propertiesmentioning

confidence: 99%

Traditional Uses, Phytochemistry, and Bioactivities ofCananga odorata(Ylang-Ylang)

Tan

Lee

Yin

et al. 2015

Evidence-Based Complementary and Alternative Medicine

145

106

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“…Several works have demonstrated the anti-inflammatory activity of extracts of C. odorata, and some constituents of YEO [19][20][21][22]. However, studies that evaluated the effects of YEO on leukocyte activation and inflammatory response in experimental models are insufficient.…”

Section: Introductionmentioning

confidence: 99%

Effect of Ylang-Ylang (Cananga odorata Hook. F. & Thomson) Essential Oil on Acute Inflammatory Response In Vitro and In Vivo

et al. 2022

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The aim of this study is to evaluate the phytochemical profile, oral acute toxicity, and the effect of ylang-ylang (Cananga odorata Hook. F. & Thomson) essential oil (YEO) on acute inflammation. YEO was analyzed by gas chromatography/mass spectrometry. For in vitro tests, YEO was assessed using cytotoxicity, neutrophil chemotaxis induced by N-formyl methionyl leucyl phenylalanine (fMLP), and phagocytic activity tests. YEO was orally administered in zymosan-induced peritonitis, carrageenan-induced leukocyte rolling, and adhesion events in the in situ microcirculation model and in carrageenan-induced paw edema models. YEO (2000 mg/kg) was also tested using an acute toxicity test in Swiss mice. YEO showed a predominance of benzyl acetate, linalool, benzyl benzoate, and methyl benzoate. YEO did not present in vitro cytotoxicity. YEO reduced the in vitro neutrophil chemotaxis induced by fMLP and reduced the phagocytic activity. The oral treatment with YEO reduced the leukocyte recruitment and nitric oxide production in the zymosan-induced peritonitis model, reduced rolling and adherent leukocyte number induced by carrageenan in the in situ microcirculation model, and reduced carrageenan-induced edema and mechanical hyperalgesia. YEO did not present signs of toxicity in the acute toxicity test. In conclusion, YEO affected the leukocyte activation, and presented antiedematogenic, anti-hyperalgesic, and anti-inflammatory properties.

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“…Traditionally YYEO is employed as aphrodisiac (Kodithala and Murali, 2018), anxiolytics (Zhang et al, 2016), antihypertensive (Jung et al, 2013), antiseptic (Caacbay and Jacinto, 2009), in food and beverages as a fragrance agent (Burdock and Carabin, 2008). Cananga odorata extract was proven to have a cytotoxic effect against hepatocellular carcinoma cancer cell lines, HepG2, and Hep2.2.15 Tan et al (2015) and antiin lammatory effect (Maniyar and CH, 2015). The cytotoxic oxoaporphine alkaloid liriodenine, isolated from Cananga odorata, was found to be a potent inhibitor of topoisomerase II both in vitro and in vivo (Woo et al, 1997).…”

Section: Introductionmentioning

confidence: 99%

Anticancer activity of ylang-ylang essential oil in Ehrlich Ascites Carcinoma cell-treated mice

Malgi

Rasal

Patil³

et al. 2020

ijrps

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Essential oils are secondary metabolites contains a complex mixture of with a diverse array of chemical structures, play a crucial role in the management of complex diseases like cancer via synergistic and antagonism effect. essential oil (YYEO) extracted from the flowers of Cananga is renowned forits fragrance, contained more than 150 essential components within it, and utilized in various diseases and cosmetics. Traditionally YYEO is being used as an aphrodisiac, , , antiseptic, in food and beverages as a fragrance agent. Due to the presence of a complex mixture of essential components in YYEO, we aimed the current study to assess the anticancer potential against Ehrlich Carcinoma (EAC) bearing mice. In antioxidant, growth, body weight, biochemical, , and serum estimation was evaluated with subsequent of the liver. 5- (5- FU) was used as a standard drug. YYEO showed potent antioxidant activity by DPPH assay. YYEO significantly reversed the , lymphocytes, WBC, and RBC numbers in the treated group compared with the disease control group. YYEO administration has restored the imbalanced levels of antioxidant such as MDA, GSH, and SOD activity. YYEO reversed the of the liver altered by the EAC in mice. In conclusion, a complex mixture of contained in YYEO could be the potent anticancer therapy in the future. Further studies are needed to identify the active principles and the mechanism involved in this activity.

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Evaluation of Anti-Inflammatory Activity of Ethanolic Extract of Cananga Odorata Lam in Experimental Animals

Cited by 6 publications

References 7 publications

Traditional Uses, Phytochemistry, and Bioactivities ofCananga odorata(Ylang-Ylang)

Traditional Uses, Phytochemistry, and Bioactivities ofCananga odorata(Ylang-Ylang)

Effect of Ylang-Ylang (Cananga odorata Hook. F. & Thomson) Essential Oil on Acute Inflammatory Response In Vitro and In Vivo

Anticancer activity of ylang-ylang essential oil in Ehrlich Ascites Carcinoma cell-treated mice

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