Evaluation of Anti-inflammatory Activity of Chloroform Extract of Bryonia laciniosa in Experimental Animal Models

Gupta, Malaya; Mazumdar, Upal Kanti; Sivakumar, T.; Vamsi, Madgulav Laxmi Mohan; Karki, Subhas S.; Sambathkumar, R; Manikandan, L. C.

doi:10.1248/bpb.26.1342

Cited by 47 publications

(30 citation statements)

References 8 publications

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“…30) The cotton pellet granuloma method is a suitable test for assessing the antiin‰ammatory activity drugs and widely used to evaluate the transudative and proliferative components of chronic in‰ammation. 31) Our results showed that the methanol extracts of EM and EB signiˆcantly inhibited the growth of granuloma tissue in a nondosedependent manner. On the contrary, AB showed little eŠect on reducing the weight of granuloma.…”

Section: Discussionmentioning

confidence: 53%

Comparison of the Antiinflammatory Activities of Three Medicinal Plants Known as “Meiduoluomi” in Tibetan Folk Medicine

Zhang

Luo

Li³

et al. 2008

YAKUGAKU ZASSHI

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Erigeron breviscapus (Vant.) Hand-mazz (EB), Erigeron multiradiatus (Lindl.) Benth (EM), and Aster brachytrichus Franch (AB), confused under the vernacular name``meiduoluomi'' by native people and traditional healers, have been used for the treatment of meningitis, polyneuritis, hepatitis, adenolymphitis, and enteronitis in traditional Tibetan medicine. In this study, the antiin‰ammatory activity of methanol extracts of all three plants was investigated in the xylene-induced ear edema model, carrageenan-induced paw edema model, and cotton pellet-induced granuloma model. It was found that the methanolic extracts of both EB and EM had strong inhibitory eŠects on the acute phase of in‰ammation in carrageenan-induced paw edema in rats. On the other hand, the methanolic extract of EM showed stronger eŠects than those of EB in xylene-induced ear edema. In the chronic test, the methanolic extracts of EB and EM resulted in a signiˆcant reduction in granuloma weight in rats. In addition, myeloperoxidase (MPO) activity was strongly reduced in the EB-treated and EM-treated groups, which indicated that EB and EM can inhibit certain in‰ammatory modulator factors that cause neutrophil aggregation in in‰amed tissue, e.g., nuclear factor-kB. However, the methanolic extracts of AB had no antiin‰ammatory eŠects in the tested models and MPO assay. The similar eŠects of EM and EB in tested models provided some scientiˆc basis for the traditional usage of meiduoluomi in in‰ammatory disease. However, the results also suggest that further study is needed to investigate the antiin‰ammatory proˆle of AB and provide a scientiˆc basis for the use of AB in in‰ammatory diseases.

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Section: Discussionmentioning

confidence: 53%

Comparison of the Antiinflammatory Activities of Three Medicinal Plants Known as “Meiduoluomi” in Tibetan Folk Medicine

Zhang

Luo

Li³

et al. 2008

YAKUGAKU ZASSHI

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“…This test was used for initial screening to select the best dose (50 mg/kg) for the other tests of anti-inflammatory activity. Indomethacin was chosen as a positive control because it is a very effective antiinflammatory nonsteroidal drug that is widely used in the literature (Gupta et al, 2003;Tunalier et al, 2007).…”

Section: Thioglycolate Induced Peritonitismentioning

confidence: 99%

Anti-inflammatory and analgesic potential of Caesalpinia ferrea

Lima¹,

Araújo²,

Sitônio³

et al. 2012

Rev. bras. farmacogn.

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Caesalpinia ferrea Mart. belongs to the family Fabaceae. Known as pau-ferro and jucá, it is used in folk medicine to treat diabetes, as antipyretic and antirheumatic. This study aimed to evaluate the anti-inflammatory and antinociceptive activities of the ethanol extract of the fruits of C. ferrea (EECf). In the evaluation of anti-inflammatory activity, EECf (50 mg/kg) produced significantly inhibition of ear edema by 66.6% compared to control. Indomethacin (10 mg/kg) showed inhibition of 83.9% compared to control. EECf (50 mg/kg) inhibited of vascular permeability induced by acetic acid and was also able to reduce of cell migration to the peritoneal cavity induced by thioglycolate. In the writhing test induced by acid acetic, EECf (12.5, 25 and 50 mg/kg) significantly reduced the number of contortions by 24.9, 46.9 and 74.2%, respectively. In the formalin test, EECf presented effects only in the second phase. The results provided experimental evidence for the effectiveness of the traditional use of C. ferrea in treating various diseases associated with inflammation and pain.

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“…The Cotton pellets-induced granuloma test was performed according to the method of Gupta et al (2003). The rats were divided into five groups (n = 6).…”

Section: Cotton Pellets-induced Granulomamentioning

confidence: 99%

Evaluation of the analgesic and anti-inflammatory properties of methanol extract of Artanema sesamoides Benth roots in animal models

Gupta¹,

Mazumder²,

Selvan³

et al. 2008

Oriental Pharmacy and Experimental Medicine

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SUMMARYThe methanol extract of the root of Artanema sesamoides Family Scrophuilariaceae (MEAS) was investigated for possible analgesic and anti-inflammatory effects in animals. Three models were used to study the extract effects on nociception, which were acetic acid-induced writhing response, hot-plate method and the tail flick test in mice. The antiinflammatory effects were evaluated using carrageenan, dextran, histamine and serotonin induced rat paw oedema (acute) and cotton pellet induced granuloma (chronic) models in rats. Results of the study revealed that the extract exhibited significant (P < 0.001) analgesic effect at a dose of 50, 100 and 200 mg/kg b.w p.o in mice in all the models. In acute model, the MEAS also exhibited significant (P < 0.001) antiinflammatory effect in all the above mentioned doses. In chronic model (cotton pellet induced granuloma) the MEAS 200 mg/kg and indomethacin 10 mg/kg showed that inhibition of granuloma formation 25.0% and 47.7% respectively (P < 0.001). The MEAS and indomethacin were effectively preventing the transudation of the fluid. Thus, the present study revealed that the methanol extract of the root of Artanema sesamoides exhibited significant analgesic and antiinflammatory activity.

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Evaluation of Anti-inflammatory Activity of Chloroform Extract of Bryonia laciniosa in Experimental Animal Models

Cited by 47 publications

References 8 publications

Comparison of the Antiinflammatory Activities of Three Medicinal Plants Known as “Meiduoluomi” in Tibetan Folk Medicine

Comparison of the Antiinflammatory Activities of Three Medicinal Plants Known as “Meiduoluomi” in Tibetan Folk Medicine

Anti-inflammatory and analgesic potential of Caesalpinia ferrea

Evaluation of the analgesic and anti-inflammatory properties of methanol extract of Artanema sesamoides Benth roots in animal models

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