Evaluation of Anti-inflammatory and Anti-diarrhoeal Activity of Leaf Aqueous Extracts of Zizyphus Lotus (L) in Albino Wistar Rats

Hani, Amira Fatma; Zaouani, Mohamed; Mimoune, Nora; Ainouz, Lynda; Djellout, B.; REMICHI, Hayat; Boudjellaba, Sofiane; Bouchoucha, Afaf

doi:10.15835/buasvmcn-vm:2019.0041

Cited by 3 publications

(3 citation statements)

References 26 publications

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“…Among these substances, polyphenols from jujube, secondary metabolites of plants, are important determinants of the nutritional and organoleptic qualities of Zizyphus lotus [21,22]. Several bioactive compounds extracted from jujubes have attracted the attention of many researchers due to their important biological actions, including antioxidant [19,23], enzyme inhibitory [24,25], antiproliferative and cytotoxic effects [24,26], anti-inflammatory, and other effects [27][28][29], which can be used in the food, pharmaceutical, and cosmetic industry.…”

Section: Introductionmentioning

confidence: 99%

Ultrasound Assisted Extraction of Phenolic Compounds from a Jujube By-Product with Valuable Bioactivities

et al. 2020

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Jujube plant is a potential source of polyphenols with biological propreties. The purpose of this study was to investigate the application of ultrasound technique for extracting phenolic compounds (TPC) from seeds of Zizyphus lotus under optimization conditions based on response surface methodology. A maximum TPC, total flavonoids content (TFC), and total condensed tannins content (TTC) of 2383.10 ± 0.87 mg GAE/100g, 486.50 ± 0.38 mg QE/100g and 15,787.10 ± 0.10 mg CE/100g, respectively obtained under ethanol concentration 50.16%, sonication temperature 29.01 °C, sonication time 15.94 min and solvent-to-solid ratio 34.10:1 mL/g. The optimized extract was then evaluated for its antioxidant, antiacethylcholinesterase, antihypercholesterolemia, and antiproliferative activities. The results showed that ultrasound method is a green and safe method that can be used to effectively extract TPC from jujube seeds. The biological activity of Zizyphus extract exhibited a very good antioxidant against DPPH (EC50 = 0.39 µg/mL) and FRAP (1670.42 ± 6.5 mg/100 g). Additionally, it possesses acetylcholinesterase (AChE) inhibitory effect (IC50 = 0.93 ± 0.01 mg/mL) and HMGR inhibition (45.41%) using 100 µg/mL. The extract significantly inhibits cell proliferation on the MCF-7 and HepG2 tumor cell lines with an IC50 values of <0.05 and 3 ± 0.55 mg/mL, respectively. Therefore, the ultrasound method can be considered a method for obtaining a significant anticancer activity with respect to the lines and therefore makes it possible to recover a maximum of phenolic compounds in less time with an AChE and HMGR inhibitory activity. Thus, it can be suggested that Zls extract is a promising fruit for the development of supplementary dietary due to its potential behaviour as nutraceutical.

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Section: Introductionmentioning

confidence: 99%

Ultrasound Assisted Extraction of Phenolic Compounds from a Jujube By-Product with Valuable Bioactivities

et al. 2020

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“…Both plants are popularly known in Algeria and the most used in the treatment of various pathologies. Previous studies have demonstrated the antidiarrheal effects of Z. lotus and R. chalepensis (Hani et al 2020;Degu et al 2020). Zazouli et al (2022) and Letaief et al (2021) have determined an important antiproliferative activity of Z. lotus extract against cancer cell lines, in addition of an interesting antimicrobial activity.…”

Section: Introductionmentioning

confidence: 99%

Acute toxicity and therapeutic application of Zizyphus lotus and Ruta chalepensis phenolic extracts in treatment of gastroenteritis induced by Salmonella enterica subsp. arizonae

Bekkar,

Bouabsa,

Meddah

et al. 2023

Acta Biol Szeged

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This study aimed to evaluate the antigastroenteritis effect against Salmonella enterica subsp. arizonae after therapeutic application of hydromethanolic extracts (MeOH.E) and aqueous extracts (Aq.E) of Zizyphus lotus (ZL) and Ruta chalepensis (RC). Acute oral toxicity was elucidated using in vivo methods and antigastroenteritis effect were evaluated using S. enterica subsp. arizonae-induced diarrheal model. Furthermore, test groups were treated with 400 mg/kg of the MeOH.E and Aq.E of each plant, while the control group was given neomycin (200 mg/kg) as standard antibiotic treatment, positive and negative controls were given the infectious germ (4 × 106 cells/mL) and 0.9% saline solution NaCl (10 ml/kg), respectively. Both plants extracts showed no toxicity for all the animals, so the LD50 was found to be greater than 5000 mg/kg. Moreover, an important bactericidal effect, using both plants extracts was determined against S. enterica subsp. arizonae cells in the intestine. In parallel, a decrease in alkaline phosphatase, amino alanine transferase and aspartate aminotransferase levels was observed with reduction in blood erythrocyte sedimentation rate in all treated animals. Thus, these results could be exploited in the medical field for the formulation of potent antibacterial drugs that cure severe gastrointestinal infections.

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“…This plant belongs to the Rhamnaceae family [30][31][32]. Several sections of ZL plant are widely used in traditional medicine for the treatment of many diseases, human nutrition and healthpromotion [33]. Numerous scientific reports have indicated that this plant contains significant amounts of glutamic acid, sterols, vitamins, fibers, amino acids, triacylglycerol, mineral matter and antioxidant compounds [34][35][36].…”

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confidence: 99%

Investigation of Ziziphus Lotus Leaves Extract Corrosion Inhibitory Impact on Carbon Steel in a Molar Hydrochloric Acid Solution

Lahmady¹,

Anor²,

Forsal³

et al. 2023

Port. Electrochim. Acta

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In this research, ZL leaves extract was used as a new friendly inhibitor for improving CS corrosion resistance in a 1.0 M HCl solution. The extract performance was evaluated by PDP and EIS techniques. The outcomes of this investigation showed that corrosion IE% of ZL leaves C2H5OH extract raised from 86 to 95%, with concentrations from 1 to 3 g/L. EIS method confirmed that the extract IE% was stable in the long-term. However, when the test temperature increased from 293 K to 323 K, IE% decreased from 95 to 90%. PDP experiments results revealed that ZL leaves extract operated as a mixed-type inhibitor, with anodic predominance.

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Evaluation of Anti-inflammatory and Anti-diarrhoeal Activity of Leaf Aqueous Extracts of Zizyphus Lotus (L) in Albino Wistar Rats

Cited by 3 publications

References 26 publications

Ultrasound Assisted Extraction of Phenolic Compounds from a Jujube By-Product with Valuable Bioactivities

Ultrasound Assisted Extraction of Phenolic Compounds from a Jujube By-Product with Valuable Bioactivities

Acute toxicity and therapeutic application of Zizyphus lotus and Ruta chalepensis phenolic extracts in treatment of gastroenteritis induced by Salmonella enterica subsp. arizonae

Investigation of Ziziphus Lotus Leaves Extract Corrosion Inhibitory Impact on Carbon Steel in a Molar Hydrochloric Acid Solution

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