Evaluation of anti-inflammatory effect of fucoxanthin isolated from brown algae in lipopolysaccharide-stimulated RAW 264.7 macrophages

Heo, Soo‐Jin; Yoon, Weon‐Jong; Kim, Kil-Nam; Ahn, Ginnae; Kang, Sung-Myung; Kang, Do‐Hyung; Affan, Abu; Oh, Chulhong; Jung, Won‐Kyo; Jeon, You‐Jin

doi:10.1016/j.fct.2010.05.003

Cited by 306 publications

(182 citation statements)

References 32 publications

Supporting

Mentioning

165

Contrasting

Unclassified

Order By: Relevance

“…As previously reported fucoxanthin and a polysaccharide isolated from brown seaweed Ecklonia cava significantly suppressed the release of PGE 2 in RAW 264.7 cells (Heo et al 2010). …”

Section: Effect Of the Compounds On Lps-induced No Productionsupporting

confidence: 53%

“…The chronic expression of NO could also be associated with various carcinomas and inflammatory conditions. In addition, NO production could also be increased by the production of iNOS under pathological conditions (Heo et al 2010). Therefore, it is clear that inhibition of NO production may have therapeutic value over inflammatory diseases.…”

Section: Effect Of the Compounds On Lps-induced No Productionmentioning

confidence: 99%

“…Since the dawn of 21st century, there has been an increase in the search for natural bioactive compounds as lead metabolites for pharmaceutical, cosmeceutical, and functional food industry (Heo et al 2010, Lee et al 2013b. This is partly due to the increase in health awareness and stringent regulations pertaining to the addition of synthetic chemicals in food and pharmaceuticals.…”

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

5β-Hydroxypalisadin B isolated from red alga Laurencia snackeyi attenuates inflammatory response in lipopolysaccharide-stimulated RAW 264.7 macrophages

Wijesinghe¹,

Kang²,

Lee³

et al. 2014

ALGAE

Self Cite

View full text Add to dashboard Cite

In this study, four compounds isolated from the red alga Laurencia snackeyi were evaluated for their potential antiinflammatory effect in lipopolysaccharide (LPS)-stimulated RAW 264.7 macrophages. These compounds were tested for their inhibitory effects on nitric oxide (NO) production in LPS-stimulated RAW 264.7 cells. Since 5β-hydroxypalisadin B showed the best activity it was further tested for the production of prostaglandin-E 2 (PGE 2 ), expression of inducible nitric oxide synthase (iNOS) and cyclooxygenase-2 (COX-2), the release of pro-inflammatory cytokines tumor necrotic factor-alpha (TNF-α), interleukin-1β (IL-1β), and interleukin-6 (IL-6). 5β-Hydroxypalisadin B significantly reduced the PGE 2 release and suppressed the iNOS and COX-2 expression in LPS-stimulated RAW 264.7 cells. It also significantly reduced the release of pro-inflammatory cytokines TNF-α, IL-1β, and IL-6. These findings provide the first evidence of antiinflammatory potential of 5β-hydroxypalisadin B isolated from the red alga L. snackeyi and hence, it could be exploited as an active ingredient in pharmaceutical, nutraceutical and functional food applications.

show abstract

“…As previously reported fucoxanthin and a polysaccharide isolated from brown seaweed Ecklonia cava significantly suppressed the release of PGE 2 in RAW 264.7 cells (Heo et al 2010). …”

Section: Effect Of the Compounds On Lps-induced No Productionsupporting

confidence: 53%

Section: Effect Of the Compounds On Lps-induced No Productionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

5β-Hydroxypalisadin B isolated from red alga Laurencia snackeyi attenuates inflammatory response in lipopolysaccharide-stimulated RAW 264.7 macrophages

Wijesinghe¹,

Kang²,

Lee³

et al. 2014

ALGAE

Self Cite

View full text Add to dashboard Cite

show abstract

“…Sulfoglycerolipid demonstrated antibacterial [25] and antiviral activities [26]. The carotenoid fucoxanthin has an antioxidant and anticancer properties [27], and has shown anti-inflammatory effect [28]- [30]. Seasonal accumulation of these compounds may be of interest for applied purposes.…”

Section: Introductionmentioning

confidence: 99%

Seasonal Composition of Lipids, Fatty Acids Pigments in the Brown Alga <i>Sargassum pallidum</i>: The Potential for Health

Gerasimenko¹,

Logvinov²

2016

OJMS

View full text Add to dashboard Cite

The present study describes the content of total lipids (TL), the main components of polar and neutral lipids (NL) and photosynthetic pigments (PSP) in edible seaweed Sargassum pallidum (Ochrophyta) from the Sea of Japan, Russia, in different months of the year, taking into account life cycle. Special attention was paid to the fatty acids (FAs) of total lipids as well as the accumulation of important polyunsaturated fatty acids (PUFAs) in glyceroglycolipids (GL) and reserve lipids in the seasonal cycles of growth. The content of TL strongly varied in the course of a year. The major lipid components were GL (20.3% -36.4%) and NL (19.8% -30.6%), while phospholipids (PL) were present in negligible amounts (3.2% -6.9%). Significant seasonal variations were observed in content all classes of lipids. The PUFAs prevailed in total lipids and the content of n-6 PUFAs was higher than n-3 PUFAs on all stages of life with the exception of vegetation period. Monogalactosyldiacylglycerols (MGDG) and digalactosyldiacylglecerols (DGDG) were rich in PUFAs and n-3 PUFAs were dominated among them independently of stages of growth. Saturated fatty acids (SFA) were dominated in sulfoquinovosyldiacylglycerols (SQDG). Triacylglycerols (TAG) and diacylglycerols (DAG) contained many PUFAs, especially n-6 PUFAs. Significant concentration 20:3 n-6 was in the triacylglycerols. The concentration of chlorophylls and carotenoids was increased with the growth and maturation of S. pallidum and reached maximum in period of highest day length and water temperature. The content of pigments decreased with the onset of short days and decreasing water temperatures. Nutritional value and benefit for health of human this alga were evaluated. The n-6/n-3 PUFAs ratio, nutritional quality index (atherogenic and thrombogenic indices, and ratio between hypocholesterolemic and hypercholesterolemic fatty acids) were low, suggesting a high nutritional value of S. pallidum throughout the year.

show abstract

“…Shiratori et al [35] reported that effect of FUCO is comparable with commercially anti-inflammatory steroidal drug prednisolone. Heo et al [36] screened inhibitory effect of NO production from nine species of brown algae and confirmed that inhibition of NO production correlates with FUCO contents. FUCO treatment attenuates the productions of NO and PGE 2 by inhibiting inducible NO synthase (iNOS) and cyclooxigenase-2 (COX-2) expressions.…”

Section: Discussionmentioning

confidence: 99%

Evaluation of Anti-Inflammatory and Anti-Proliferative Effect of Hydroxy-, Keto-, and Epoxy-Carotenoids in RAW 264.7 and HL-60 Cells

Vijay¹,

Sowmya²,

Arathi³

et al. 2016

J Food Chem Nanotechnol

View full text Add to dashboard Cite

Aim of the study was to investigate efficiency of hydroxy (lutein, LUT), Keto-(astaxanthin, AST) and epoxy-(fucoxanthin, FUCO) carotenoids on molecular/biochemical events in proliferation of RAW 264.7 and HL-60 cells. Lipopolysaccharide (LPS) induced RAW 264.7 cells treated either with 20 µM of LUT or AST or FUCO or without carotenoid for 12 h, and studied their differential influence on toxicity, inflammatory markers and nuclear factor-κB p65 (NF-κB p65) expression levels. Similarly, HL-60 cells treated for 48 h and evaluated cytotoxicity and apoptosis inducing activity. It was observed, carotenoids treatment decreased cytotoxicity of LPS induced inflammation in macrophages. Among carotenoids, FUCO protects cytotoxicity by 10.7 and 15.8% than AST and LUT, respectively. Likewise, carotenoids treatments reduced Nitric oxide (NO), Prostaglandin E 2 (PGE 2 ) and NF-κB p65 levels than LPS treated group, while FUCO shown to be superior to control markers of inflammation than AST and LUT. Similarly, in case of HL-60 cells, FUCO significantly reduced cell viability by 16.4 and 33.4% than AST and LUT, respectively. Further, increased apoptosis of HL-60 positively correlates with decreased glutathione, and increased malondialdehyde and oxidative stress in cells treated with FUCO than AST and LUT. Also, typical apoptotic morphological changes were observed in FUCO treated cells than other oxygenated carotenoids. These differences among oxygenated carotenoids may be due to functional group and reactivity with the cells. Further, we presumed that an increase in the number of oxygen or hydroxyl groups in the carotenoids may decide the bioactivity. This study provides a greater insight of oxygenated carotenoids to combat chemoprevention of cancers originating from inflammation.

show abstract

Evaluation of anti-inflammatory effect of fucoxanthin isolated from brown algae in lipopolysaccharide-stimulated RAW 264.7 macrophages

Cited by 306 publications

References 32 publications

5β-Hydroxypalisadin B isolated from red alga Laurencia snackeyi attenuates inflammatory response in lipopolysaccharide-stimulated RAW 264.7 macrophages

5β-Hydroxypalisadin B isolated from red alga Laurencia snackeyi attenuates inflammatory response in lipopolysaccharide-stimulated RAW 264.7 macrophages

Seasonal Composition of Lipids, Fatty Acids Pigments in the Brown Alga <i>Sargassum pallidum</i>: The Potential for Health

Evaluation of Anti-Inflammatory and Anti-Proliferative Effect of Hydroxy-, Keto-, and Epoxy-Carotenoids in RAW 264.7 and HL-60 Cells

Contact Info

Product

Resources

About

Evaluation of anti-inflammatory effect of fucoxanthin isolated from brown algae in lipopolysaccharide-stimulated RAW 264.7 macrophages

Cited by 306 publications

References 32 publications

5β-Hydroxypalisadin B isolated from red alga Laurencia snackeyi attenuates inflammatory response in lipopolysaccharide-stimulated RAW 264.7 macrophages

5β-Hydroxypalisadin B isolated from red alga Laurencia snackeyi attenuates inflammatory response in lipopolysaccharide-stimulated RAW 264.7 macrophages

Seasonal Composition of Lipids, Fatty Acids Pigments in the Brown Alga &lt;i&gt;Sargassum pallidum&lt;/i&gt;: The Potential for Health

Evaluation of Anti-Inflammatory and Anti-Proliferative Effect of Hydroxy-, Keto-, and Epoxy-Carotenoids in RAW 264.7 and HL-60 Cells

Contact Info

Product

Resources

About

Seasonal Composition of Lipids, Fatty Acids Pigments in the Brown Alga <i>Sargassum pallidum</i>: The Potential for Health