Evaluation of anti-inflammatory effects of leaf and seed extracts of Plantago major on acetic acid-induced ulcerative colitis in rats

Farid, Armita; Sheibani, Mohammad; Shojaii, Asie; Noori, Mitra; Motevalian, Manijeh

doi:10.1016/j.jep.2022.115595

Cited by 21 publications

(5 citation statements)

References 32 publications

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“…The activity is mainly attributed to its phytochemical components such as polysaccharides, lipids, derivatives of caffeic acid, flavonoids, iridoid glycosides, and terpenoids, offering anti-inflammatory, antioxidant, analgesic, immunomodulatory, anti-ulcer and antibiotic capacities. These pharmacological properties make it a promising phytochemical for biomedical and regenerative applications [24][25][26][27][28][29].…”

Section: Introductionmentioning

confidence: 99%

Functional Electrospun Nanofibers Loaded with Plantago Major L. Extract for Potential Use in Cutaneous Wound Healing

Mancipe¹,

Queiroz²,

Santos³

et al. 2023

Preprint

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Plantago major L. is a worldwide available plant that has been used traditionally for several medical application due to its properties such as wound healing, anti-inflammatory, antimicrobial etc. This work aimed to develop and evaluate nanostructured PCL electrospun dressing with P. major extract encapsulated in nanofibers for application in wound healing. The extract from leaves was obtained by extraction in a mixture of water:ethanol= 1:1 of the freeze-dried extract presented a minimum inhibitory concentration (MIC) for Staphylococcus Aureus susceptible and resistant to methicillin of 5.3 mg/mL, a high antioxidant capacity, but a low content of total flavonoids. Electrospun mats without defects were successfully produced using two P. major extract concentrations based on MIC value. The extract incorporation in PCL nanofibers was confirmed by FTIR and contact angle measurements. The PCL/P. major extract was evaluated by DSC and TGA demonstrating that incorporation of the extract decreases the thermal stability of the mats as well as the degree of crystallinity of PCL-based fibers. The P. major extract incorporation on electrospun mats produced a significant swelling degree (more than 400%) and increased the capacity of adsorbing wound exudates and moisture, important characteristics for skin healing. The extract-controlled release evaluated by in vitro study in PBS (pH, 7.4) shows that P. major extract delivery from the mats occurs in the first 24 h, demonstrating their potential capacity to be used in wound healing.

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Section: Introductionmentioning

confidence: 99%

Functional Electrospun Nanofibers Loaded with Plantago Major L. Extract for Potential Use in Cutaneous Wound Healing

Mancipe¹,

Queiroz²,

Santos³

et al. 2023

Preprint

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“…Based on phytochemical investigations, P. major contains volatile compounds, triterpenoids, phenolic acids, and flavonoids[ 132 ]. Traditional Persian medicine describes the benefits of P. major on wound healing, treatment of intestinal ulcers, hematemesis, upper and lower gastrointestinal bleeding, dyspepsia, hemorrhoids, stomachache, and dysentery[ 133 ]. A case study discovered that decoction of P. major alleviated patient symptoms within a few days of starting therapy, indicating the potential benefits of P. major for treating pancolitis[ 134 ].…”

Section: Discussionmentioning

confidence: 99%

Acknowledging the use of botanicals to treat diabetic foot ulcer during the 21^st century: A systematic review

Narzary¹,

Swarnakar²,

Kalita³

et al. 2023

World J Clin Cases

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BACKGROUND Diabetic foot ulcer (DFU) is a serious health issue of diabetes mellitus that affects innumerable people worldwide. Management and treatment of this complication are challenging, especially for those whose immune system is weak. AIM To discuss the plants and their parts used to heal DFU, along with the mode of their administration in diabetic patients. METHODS The original articles on “the plants for the treatment of DFU” studied in clinical cases only were obtained from various bibliographic databases using different keywords. RESULTS The search resulted in 22 clinical cases records with 20 medicinal plants belonging to 17 families on 1553 subjects. The fruits and leaves were the most preferentially used parts for DFU treatment, regardless of whether they were being administered orally or applied topically. Of the 20 medicinal plants, 19 reported their effectiveness in increasing angiogenesis, epithelialization, and granulation, thus hastening the wound-healing process. The efficacy of these botanicals might be attributed to their major bioactive compounds, such as actinidin and ascorbic acid (in Actinidia deliciosa ), 7-O-(β-D-glucopyranosyl)-galactin (in Ageratina pichinchensis ), omega-3-fatty acid (in Linum usitatissimum ), isoquercetin (in Melilotus officinalis ), anthocyanins (in Myrtus communis ), and plantamajoside (in Plantago major ). CONCLUSION The validation of mechanisms of action underlying these phytocompounds contributing to the management of DFU can aid in our better understanding of creating efficient treatment options for DFU and its associated problems.

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“…30 P. major has been the focus of various investigations and observations within the fields of herbal medicine and botany. 31 Based on extensive research, it has been shown that the pharmacological advantages and impacts attributed to P. major are inherently connected to beta-sitosterol. 32,33 The bioactive ingredient not only contributes to the medical capabilities of the plant but also plays a crucial part in characterizing them; therefore, gaining knowledge about the extraction process, features, and advantages of Plantago major may provide significant insights into the medicinal potential of this plant.…”

Section: Discussionmentioning

confidence: 99%

Isolation, identification, and structure elucidation of Beta-sitosterol from Iraqi Plantago major using GC-MS, HPTLC, NMR, and FTIR

Badea Albadri,

Saleh,

Mohammed Hasan

2023

F1000Res

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Background: Plantago major, a plant well recognized for its therapeutic features, has been widely adopted in several cultural instances and conventionally used due to its anti-inflammatory, antibacterial, and wound-healing characteristics. Recent research efforts have been focused on the identification and validation of the phytochemical elements of P. major in order to establish their association with their corresponding pharmacological effects. The main aim of this study is to precisely define, isolate, purify, and completely analyse the chemical composition of beta-sitosterol, a phytosterol obtained from the Plantago major plant native to Iraq. Methods: In November 2021, P. major samples were procured from the Al-Salihiya Neighbourhood in Baghdad. These samples were afterward verified for authenticity by the Iraqi local Herbarium, located at the Al-Razi institute for alternative medicine. The desiccated botanical matter was subjected to a hexane-based defatting process inside a Soxhlet device, followed by gas chromatography/mass spectrometry (GC/MS) analysis in order to ascertain the presence of bioactive compounds. The evaluation of beta-sitosterol’s presence was afterwards conducted via the use of conventional and preparative thin layer chromatography (TLC) methodologies and high-performance thin layer chromatography (HPTLC). The identification of the molecule was further validated by the use of Fourier transform infrared (FTIR) and nuclear magnetic resonance (NMR) spectroscopy techniques. Results: The findings revealed that Compound No. 5 had notable attributes that were consistent with those of Beta-Sitosterol. The provided data pertains to mass spectrometry (MS), especially the observation of a molecular ion peak at 414. This finding is consistent with the previously documented characteristics of beta-sitosterol. This finding provides further evidence supporting its classification as a prominent organic component originating from P. major. Conclusions: We effectively determined beta-sitosterol as the primary bioactive component in the P. major samples collected. The compound’s existence highlights the plant’s longstanding therapeutic standing, ascribing it several advantageous pharmacological benefits.

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Evaluation of anti-inflammatory effects of leaf and seed extracts of Plantago major on acetic acid-induced ulcerative colitis in rats

Cited by 21 publications

References 32 publications

Functional Electrospun Nanofibers Loaded with Plantago Major L. Extract for Potential Use in Cutaneous Wound Healing

Functional Electrospun Nanofibers Loaded with Plantago Major L. Extract for Potential Use in Cutaneous Wound Healing

Acknowledging the use of botanicals to treat diabetic foot ulcer during the 21^st century: A systematic review

Isolation, identification, and structure elucidation of Beta-sitosterol from Iraqi Plantago major using GC-MS, HPTLC, NMR, and FTIR

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Evaluation of anti-inflammatory effects of leaf and seed extracts of Plantago major on acetic acid-induced ulcerative colitis in rats

Cited by 21 publications

References 32 publications

Functional Electrospun Nanofibers Loaded with Plantago Major L. Extract for Potential Use in Cutaneous Wound Healing

Functional Electrospun Nanofibers Loaded with Plantago Major L. Extract for Potential Use in Cutaneous Wound Healing

Acknowledging the use of botanicals to treat diabetic foot ulcer during the 21st century: A systematic review

Isolation, identification, and structure elucidation of Beta-sitosterol from Iraqi Plantago major using GC-MS, HPTLC, NMR, and FTIR

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Acknowledging the use of botanicals to treat diabetic foot ulcer during the 21^st century: A systematic review