Evaluation of anti-inflammatory effects of Broussonetia papyrifera stem bark

Wu, Wen-Tung

doi:10.4103/0253-7613.91862

Cited by 13 publications

(7 citation statements)

References 24 publications

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“…B. papyrifera extract is traditionally used for herbal medicine. In previous study results, B. papyrifera has demonstrated anti-inflammatory [16,17], antioxidant [18], antityrosinase [19], anticancer [20], antinociceptive [21], and antimicrobial effects [22]. Our study demonstrated that B. papyrifera extract treatment regulated WNT/β-catenin and IL-4 / STAT6 signaling pathways in hHFDP cells and stimulated hair growth in clinical subjects.…”

Section: Introductionsupporting

confidence: 63%

“…In this study, we examined the potential of developing a hair growth promoting agent by using the extract of B. papyrifera, a medicinal plant belonging to the Moraceae family that is widely distributed in East Asia and China [18]. Previous studies have reported that B. papyrifera possesses anti-inflammatory, antioxidant, anti-tyrosinase, anticancer, antinociceptive, and antimicrobial properties [16][17][18]21,22]. Our study demonstrated that the native plant B. papyrifera is involved in cell cycle regulation of hair follicle cells, which are regulated via the activation of WNT-β-catenin and STAT6 signaling pathways.…”

Section: Discussionmentioning

confidence: 99%

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Broussonetia papyrifera Promotes Hair Growth Through the Regulation of β-Catenin and STAT6 Target Proteins: A Phototrichogram Analysis of Clinical Samples

et al. 2020

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Broussonetia papyrifera (B.papyrifera), belonging to the Moraceae family, is known to elicit anti-inflammatory, antioxidant, anti-tyrosinase, anticancer, antinociceptive, and antimicrobial effects. The present study has been designed to examine the effects of B. papyrifera extract on hair growth through in vitro and clinical samples. Real-time cell growth assay, T-cell factor/lymphoid enhancer-binding factor (TCF/LEF), activation of signal transducer and activator of transcription-6(STAT6) and STAT3 reporter gene function, and Western blotting was performed to examine whether B. papyrifera regulates the expression of target proteins implicated in the proliferation of human hair follicle dermal papilla (hHFDP) cells. In this human trial, using a phototrichogram, the effect of B. papyrifera on hair growth was examined by reconstitution analysis after shaving the hair of the clinical subject’s dorsal skin. B. papyrifera promoted growth equally in hHFDP cells, which is comparable to that of minoxidil and tofacitinib. Treatment with B. papyrifera extract enhanced the TCF/LEF-luciferase activity and increased the level of β-catenin protein. Moreover, B. papyrifera extract significantly suppressed interleukin-4 (IL4)-induced STAT6 phosphorylation. In clinical trial, using a phototrichogram, we assessed the hair density and total hair counts at 0, 6, and 12 weeks after the use of hair tonic containing B. papyrifera extract. After using the hair tonic for 12 weeks, the total hair count was significantly increased as compared with the subjects at the start date (n = 11). B. papyrifera promotes dermal papilla cells proliferation in vitro and clinically among human volunteers through the regulation of WNT-β-catenin and STAT6 pathways.

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Section: Introductionsupporting

confidence: 63%

Section: Discussionmentioning

confidence: 99%

Broussonetia papyrifera Promotes Hair Growth Through the Regulation of β-Catenin and STAT6 Target Proteins: A Phototrichogram Analysis of Clinical Samples

et al. 2020

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“…The physiological level of SCC in bulk cow milk is between 50×10 3 and 100×10 3 cells per mL, whereas 200×10 3 cells per mL is taken as the threshold to define a mammary quarter between healthy and infected [ 20 , 21 ]. In the present study, Group M and Group H had lower milk SCC than that of the control Group and Group L, which might due to the anti-inflammatory effect of the active ingredients in B. papyrifera [ 22 – 24 ]. It is reported that high content of milk protein was found in high SCC milk [ 25 ] and fat content was significantly increased from 3.55% to 3.72% by an increment of SCC from 100 to 200 cells/mL [ 26 ], but a decrease of milk protein content when SCC in milk was high [ 5 ].…”

Section: Discussionmentioning

confidence: 66%

Effect of Broussonetia papyrifera L. (paper mulberry) silage on dry matter intake, milk composition, antioxidant capacity and milk fatty acid profile in dairy cows

Tao

Zhang

et al. 2018

Asian-Australas J Anim Sci

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ObjectiveThis study was carried out to investigate the possible application of Broussonetia papyrifera (B. papyrifera) silage as a functional feeding stuff in dairy cattle.MethodsSeventy-two Holstein cows were divided into four groups randomly and allocated to 6 pens with 3 individuals in each group and fed the original total mixed ratio (TMR) in the dairy farm or the new TMR with 5%, 10%, and 15% B. papyrifera silage, separately. Feed intake were recorded, milk and blood samples were collected, and milk composition, blood metabolites and milk fatty acids composition were measure at the end of the experiment.ResultsDry matter intake of cows decreased when they fed on diet with B. papyrifera, but no differences were observed in body condition score, milk yield, milk protein and lactose, feed efficiency and serum metabolites between groups. Both 10% or 15% of B. papyrifera silage in the diet significantly increased the immunoglobulin A (IgA) and IgG in serum, 15% of B. papyrifera silage increased the content of serum catalase, superoxide dismutase, total antioxidant capacity, and decreased the content of 8-hydroxy-2′-deoxyguanosine. Furthermore, 10% or 15% of B. papyrifera silage resulted in a significant decrease in the milk somatic cell count, and increased the polyunsaturated fatty acids content in the milk.ConclusionThe diets with 10% to 15% of B. papyrifera silage might enhance the immune and antioxidant function of dairy cows and increase the polyunstaturated fatty acid concentration in the milk.

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“…The fruit extract is not only a traditional medicine for treating cardiovascular diseases, but also contains alkaloids as a drug candidate for treating cancer [35]. Stem bark has a high content of phenolic compounds and is a potential resource for medical pharmaceuticals and anti-inflammatory drugs [36,37]. The root system of the B. papyrifera is very developed.…”

Section: Introductionmentioning

confidence: 99%

Morphological and Physiological Changes of Broussonetia papyrifera Seedlings in Cadmium Contaminated Soil

Zhang

Zhao

et al. 2020

Plants

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Broussonetia papyrifera is a widely distributed economic tree species, and it is also a pioneer species in adverse environments. In order to investigate the growth and adaptation mechanism of B. papyrifera under cadmium (Cd) contaminated soil, potted experiments were used with six-month treatments to study Cd enrichment and the transportation, morphological and physiological characteristics of B. papyrifera tissues. The results showed that Cd mainly accumulated in the root when the Cd concentration was high (14.71 mg/kg), and the root biomass was significantly reduced by Cd stress although Cd promoted the growth of seedlings. The bioconcentration factors (BCF) increased with the increase in Cd concentration, and reached the maximum value of 0.21 at 14.71 mg/kg. On the contrary, translocation factor (TF) decreased significantly at 8.28–14.71 mg/kg Cd concentration. Cd not only led to the loose arrangement of the xylem vessels of leaves, but also changed the chlorophyll content. However, B. papyrifera could synthesize organic solutes such as soluble protein, soluble sugar and proline to reduce the intracellular osmotic potential. Our study proved that B. papyrifera has good tolerance to Cd stress and is a pioneer tree species for soil and ecological environment restoration.

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Evaluation of anti-inflammatory effects of Broussonetia papyrifera stem bark

Cited by 13 publications

References 24 publications

Broussonetia papyrifera Promotes Hair Growth Through the Regulation of β-Catenin and STAT6 Target Proteins: A Phototrichogram Analysis of Clinical Samples

Broussonetia papyrifera Promotes Hair Growth Through the Regulation of β-Catenin and STAT6 Target Proteins: A Phototrichogram Analysis of Clinical Samples

Effect of Broussonetia papyrifera L. (paper mulberry) silage on dry matter intake, milk composition, antioxidant capacity and milk fatty acid profile in dairy cows

Morphological and Physiological Changes of Broussonetia papyrifera Seedlings in Cadmium Contaminated Soil

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