Evaluation of Anti-Inflammatory Property of Maranta Arundinacea using Protein Denaturation Assay - An In vitro Study

Jose, Shilpa Merlyn; Geetha, R. V.; Rajeshkumar, S.

doi:10.9734/jpri/2021/v33i47b33190

Cited by 2 publications

(1 citation statement)

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“…These phytochemical compounds are responsible for medical applications especially antimicrobial and anti-inflammatory activities [ 27 ]. There are various research activities that create evidence for pharmacological applications of plant-based compounds which involve the identification and characterization of bioactive compounds from natural medicinal plants [ 28 , 29 , 30 ]. Protein denaturation is the main cause of inflammation and the drug used against inflammation is called an anti-inflammatory drug.…”

Section: Discussionmentioning

confidence: 99%

Anti-inflammatory activity of lauric acid, thiocolchicoside and thiocolchicoside-lauric acid formulation

Mustafa

2023

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It is of interest to develop potent and safer anti-inflammatory drugs from plants, as medicinal plants and herbs attained great attention in the medical world due to their multifunctional activities. This article studied the anti-inflammatory effects of lauric acid (LA), thiocolchicoside (TC) and thiocolchicoside–lauric acid (TC-LA) formulation. The anti-inflammatory effects of these compounds were determined by following the methods of inhibition of protein denaturation and proteinase inhibition activity. This was assessed at different concentrations to determine the 50% inhibition concentration (IC50) of the compounds. The result indicated that the activity of LA, TC, TC-LA formulation, and reference drug increased with the increase in the concentration from 10-50 μg/ml, thus proving the activity of LA, TC, and TC-LA formulation against inflammation was in a dose-dependent manner. The percentage of inhibition of protein denaturation was 59.56%, 66.94%, 86.62%, and 60.34% for LA, TC, the combination of TC-LA and standard drug, and the IC50 values were found to be 44.78 μg/mL, 37.65 μg/mL, 27.15 μg/mL and 43.42 μg/mL, respectively. The percentage of proteinase inhibition activity of LA, TC, and a combination of TC-LA and the standard drug was 66.65%, 77.49%, 94.07%, and 69.83%, and IC50 of LA, TC, a combination of TC-LA and standard drug were35.5 μg/mL, 32.12 μg/mL, 24.35 μg/mL and 37.80 μg/mL, respectively. We found out that lauric acid, thiocolchicoside, and thiocolchicoside-lauric acid formulation exhibited significant anti-inflammatory activity.

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Section: Discussionmentioning

confidence: 99%