Evaluation of anti-mutated citrullinated vimentin antibodies, anti-cyclic citrullinated peptide antibodies in patients with rheumatoid arthritis in comparison with other rheumatic diseases; a nephrology point of view

Sadeghi, Alireza; Pezeshgi, Aiyoub; Karimimoghaddam, Arezoo; Moghimi, Minoosh; Kamali, Koorosh; Naseri, Mitra; Esmaeilzadeh, Abdolreza

doi:10.15171/npj.2017.12

Cited by 3 publications

(3 citation statements)

References 57 publications

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“…Thus, there are some data that antibodies to cyclic citrullinated peptides appear many years prior to the symptoms of rheumatoid arthritis and are almost always absent in healthy individuals [ 94 ]. However, these autoantibodies are characterized by significantly higher sensitivity and specificity than ANA, which makes them much more valuable as predictive biomarkers for the laboratory diagnostics [ 95 , 96 ].…”

Section: Physiological Autoimmunity and Its Bidirectional Pathologmentioning

confidence: 99%

Antinuclear Autoantibodies in Health: Autoimmunity Is Not a Synonym of Autoimmune Disease

et al. 2021

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The incidence of autoimmune diseases is increasing. Antinuclear antibody (ANA) testing is a critical tool for their diagnosis. However, ANA prevalence in healthy persons has increased over the last decades, especially among young people. ANA in health occurs in low concentrations, with a prevalence up to 50% in some populations, which demands a cutoff revision. This review deals with the origin and probable physiological or compensatory function of ANA in health, according to the concept of immunological clearance, theory of autoimmune regulation of cell functions, and the concept of functional autoantibodies. Considering ANA titers ≤1:320 as a serological marker of autoimmune diseases seems inappropriate. The role of anti-DFS70/LEDGFp75 autoantibodies is highlighted as a possible anti-risk biomarker for autoimmune rheumatic disorders. ANA prevalence in health is different in various regions due to several underlying causes discussed in the review, all influencing additive combinations according to the concept of the mosaic of autoimmunity. Not only are titers, but also HEp-2 IFA) staining patterns, such as AC-2, important. Accepting autoantibodies as a kind of bioregulator, not only the upper, but also the lower borders of their normal range should be determined; not only their excess, but also a lack of them or “autoimmunodeficiency” could be the reason for disorders.

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Section: Physiological Autoimmunity and Its Bidirectional Pathologmentioning

confidence: 99%

Antinuclear Autoantibodies in Health: Autoimmunity Is Not a Synonym of Autoimmune Disease

et al. 2021

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show abstract

“…Thus, there is some data that antibodies to cyclic citrullinated peptides appear many years prior to the symptoms of rheumatoid arthritis and are almost always absent in healthy individuals [94]. However, these autoantibodies are characterized by significantly higher sensitivity and specificity than ANA, which makes them much more valuable as predictive biomarkers for the laboratory diagnostics [95,96].…”

Section: Physiological Autoimmunity and Its Bidirectional Pathological Changesmentioning

confidence: 99%

Antinuclear Autoantibodies in Health: Autoimmunity Is Not a Synonym of Autoimmune Disease

Пашнина¹,

Криволапова²,

Fedotkina

et al. 2020

Preprint

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Incidence of autoimmune diseases increases. Antinuclear antibodies (ANA) testing is a critical tool for their diagnosis. However, ANA prevalence in health increased over last decades, especially among young people. ANA in health occur in low concentrations, with prevalence up to 50% in some populations, which demands a cutoff revision. The review deals with origin and probable physiological or compensatory function of ANA in health, according to the concept of immunological clearance, theory of autoimmune regulation of cell functions and the concept of functional autoantibodies. Considering ANA titers ≤1:320 as a serological marker of autoimmune diseases seems inappropriate. The role of anti-DFS70/LEDGFp75 autoantibodies is highlighted as possible anti-risk biomarker for autoimmune rheumatic disorders. ANA prevalence in health is different in various regions due to several underlying causes discussed in the review, all influencing in additive combinations according to the concept of the mosaic of autoimmunity. Not only titer, but the HEp-2 IFA staining patterns, like AC-2, is also important. Accepting autoantibodies as a kind of bioregulators, not only upper, but also lower borders of their normal range should be determined. Not only their excess, but also lack of them or “autoimmunodeficiency” could be a reason of disorders.

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“…По классификации Всемирной лиги ревматологических ассоциаций второго пересмотра (Эдмонтон, 2001) выделяют следующие варианты: системный ЮИА, полиартикулярный ЮИА, олигоартикулярный ЮИА, псориатический ювенильный артрит, артрит, ассоциированный с энтезитом, недифференцированный артрит [2,17]. Следует отметить, что ни для одной из форм ЮИА нет достаточно четких лабораторных маркеров, таких, какими являются антитела к цитруллинированным пептидам при ревматоидном артрите взрослых [12,44]. В основе патогенеза различных форм ЮИА, вероятно, лежат разные механизмы.…”

Section: Introductionunclassified

Сoncentration of Anti-Inflamatory Cytokines in Cell Culture Supernatants in Children With Juvenile Idiopathic Arthritis

2019

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Juvenile idiopathic arthritis is a chronic inflammatory disease of the joints in children, mainly of autoimmune or auto-inflammatory nature. It is a heterogeneous group, which includes different subtypes of the disease. Different mechanisms may play role in the pathogenesis of distinct subtypes of juvenile arthritis. However, a long-term imbalance of pro- and anti-inflammatory cytokines is important for all subtypes of disease. The aim of the present study was to determine spontaneous and stimulated anti-inflammatory cytokines production by peripheral blood cells from the children with juvenile idiopathic arthritis. Patients of 2 to 17 years old with different subtypes of juvenile idiopathic arthritis (n = 99) and healthy children without signs of autoimmune diseases (control, n = 31) were examined. Spontaneous and phytohemagglutinin-stimulated concentrations of IL-1ra, IL-4, IL-10, TGF-β in supernatants of whole-blood cultures were determined by ELISA. Differences in the spontaneous and mitogen-stimulated secretion of the cytokines in patients with different subtypes of juvenile arthritis have not been revealed. The spontaneous IL-1ra, IL-4 and IL-10 production by blood cells in the common group of patients with juvenile idiopathic arthritis was similar to the controls. The median value of spontaneous TGF-β concentration in the patients was below the detection level, whereas blood cells of healthy children had a higher potential of spontaneous TGF-β production. IL-4 and IL-10 production after incubation of peripheral blood cells with phytohemagglutinin in patients and in the control group did not differ from the controls, while IL-1ra and TGF-β synthesis was significantly lower than in healthy children.The spontaneous and/or stimulated production of IL-1ra, TGF-β by blood cells in children with juvenile idiopathic arthritis reflects the pathogenic significance of these cytokines in disease. Stimulation of cells can reveal a latent deficiency in the synthesis of cytokines, which is not evident when determining its concentration in serum or supernatants of spontaneous whole-blood cultures.

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Evaluation of anti-mutated citrullinated vimentin antibodies, anti-cyclic citrullinated peptide antibodies in patients with rheumatoid arthritis in comparison with other rheumatic diseases; a nephrology point of view

Abstract: Evaluation of anti-mutated citrullinated vimentin antibodies, anti-cyclic citrullinated peptide antibodies in patients with rheumatoid arthritis in comparison with other rheumatic diseases; a nephrology point of view

Cited by 3 publications

References 57 publications

Antinuclear Autoantibodies in Health: Autoimmunity Is Not a Synonym of Autoimmune Disease

Antinuclear Autoantibodies in Health: Autoimmunity Is Not a Synonym of Autoimmune Disease

Antinuclear Autoantibodies in Health: Autoimmunity Is Not a Synonym of Autoimmune Disease

Сoncentration of Anti-Inflamatory Cytokines in Cell Culture Supernatants in Children With Juvenile Idiopathic Arthritis

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