Evaluation of anti-nociceptive, anti-inflammatory and antipyretic potential of Mikania cordata (Burm. f.) Robinson in experimental animal model

Abstract

is widely used for the treatment of cuts, wounds, and dengue fever in Bangladesh. In the present study, essential oil (12.5, 25 and 50 mg/kg) and two extracts, ., chloroform and ethyl acetate extracts (200, 400, 800 mg/kg b.w.) were tested for peripheral and central anti-nociceptive activity by acetic acid-induced writhing and hot plate method, respectively. Carrageenan-induced rat paw edema assay and yeast-induced hyperthermia assay were also carried out to evaluate anti-inflammatory and antipyretic properties of oil and extracts, respectively at aforesaid doses. The essential oil (50 mg/kg), chloroform extract (800 mg/kg) and ethyl acetate extract (800 mg/kg) showed potent peripheral anti-nociceptive activity having 47.33%, 29.33% and 16.65% of writhing inhibition, respectively, comparable with standard diclofenac (52.0%). Essential oil (50 mg/kg), chloroform extract (800 mg/kg) and ethyl acetate extract (800 mg/kg) presented promising central anti-nociceptive activity as well having 95.86%, 79.18% and 42.37% elongation of reaction time, respectively, at 90 min after administration of essential oil, ethyl acetate extract and 60 min after administration of chloroform extract. In anti-inflammatory activity screening, the essential oil (50 mg/kg) produced the highest 72.80% edema inhibition at 4 h after administration of carrageenan which was comparable with that of standard phenylbutazoe (87.87%). On the other hand, chloroform extract (800 mg/kg) and ethyl acetate extract (800 mg/kg) showed up to 34.31% and 15.27% of edema inhibition, respectively, at 4 h after administration of carrageenan. In antipyretic assay, the essential oil and chloroform extract displayed a strong antipyretic effect in yeast-induced rats, whereas the ethyl acetate extract had no antipyretic activity. The present study revealed anti-nociceptive, anti-inflammatory and antipyretic potential of which could be the therapeutic option against fever, inflammations as well as painful conditions and confirmed the traditional use of .

Technological prospection: the genus Mikania in therapeutic use

“…glomerata had three citations each. M. cordata (Burma f.) B. L. Robins is used therapeutically against coughs, gastrointestinal disorders, and eye sores (Siddiqui et al, 2019) some of the proven properties of the species are psychopharmacological activities, neuropharmacological, antibacterial, and therapeutic properties against pain and inflammation (Siddiqui et al, 2018).…”

Evidências científicas da atividade biológica do guaco: revisão de literatura

“…Indicando claramente que o óleo essencial e os extratos possuem ação tanto periférica e central, com efeitos anti-nociceptivos. Pode-se considerar que esta espécie possivelmente será uma fonte alternativa de analgésico em um futuro não tão distante (Siddiqui et al, 2018).…”

“…Siddiqui et al (2018), constataram que o uso de óleo essencial e extratos de folhas da M. cordata tem ação anti-nociceptivo, anti-inflamatório e antipirético. Com utilidade para o tratamento da dor, inflamações, febre como em casos de dengue.…”

Antimicrobial Activity of Cultivable Endophytic and Rhizosphere Fungi Associated with “Mile‐a‐Minute,” Mikania cordata (Asteraceae)

“…The leaf pulp is commonly used as poultice for open wounds which will cause efficient healing. The decoction of M. cordata leaves is used in treating ulcers and dysentery [10]. An ointment formulated from the leaf extract of M. cordata possessed in vitro antibacterial activity against methicillin-resistant Staphylococcus aureus and antifungal properties against Trichophyton mentagrophytes [11].…”