“…A. argyi is reported to possess multiple pharmacological activities including anti-inflammatory, antimicrobial, antiasthma, analgesic, antivirus, antioxidant, antitumor and immunomodulatory effects (Jiang et al, 2005;Ge et al, 2016;Huang et al, 2012;Bao et al, 2013;), most of which are contributed by the essential oil existing in A. argyi leaves. Though the anti-inflammatory activity of Artemisia genus has been studied intensively and several anti-inflammatory compounds were also found in this plant (Moscatelli et al, 2006;Min et al, 2009;Choi et al, 2013;Habib and Waheed, 2013;Jeong et al, 2014;Park et al, 2015;Zeng et al, 2014), there is no much substantial evidence supporting the anti-inflammatory property of this herbal medicine and the molecular targets for the effects still remain unclear, which limited its application into clinical practice. Therefore this study was aimed to evaluate the anti-inflammatory potential of the essential oil of A. argyi (AAEO), and investigate the underlying mechanisms by lipopolysaccharide (LPS)-stimulated murine macrophages and acute in vivo inflammatory model in mice.…”