Evaluation of anti-oxidative properties of <i>Tinosporacordifoliain Alloxan</i> induced diabetic Wistar rats

Abstract

Introduction and Aim: Type 2 Diabetes is a complex heterogenous disorder with marked hyperglycemia, reduced insulin sensitivity, increased oxidative stress, and altered carbohydrate, fat and protein metabolism. Increased oxidative stress is a key factor for the reduced pancreatic ? cell arose due to prolonged hyperglycemia. The present investigation admits ethanolic extract of Tinosporacordifolia (250mg/kg/body weight) as a potent antihyperglycemic agent as well as antioxidant.&#x0D; &#x0D; Materials and methods: Wistar norvegicus rats of 180-200 gm were involved in the present study divided in to 5 groups. Each group has 5 rats. Diabetes was induced by Alloxan (100mg/kg.b.wt). Administration of T.cordifolia (250mg/kg/b.wt) done in the desired group for 10,20, and 30 days respectively. Fasting blood collected for plasma glucose and the organs were collected for the antioxidant assay.&#x0D; &#x0D; Results: Each group showed significant recovery in the glucose and antioxidant parameters like Glutathione, Catalase, Ascorbate etc., Statistical analysis was done by Tukey multiple range test compared with entire column after ANOVA. Level of significance was denoted for diabetic Vs treated group having p values *** p&lt;0.05, **p&lt;0.01, *p&lt;0.001, NS-Non-significant, &gt;0.05.&#x0D; &#x0D; Conclusion: Relying on the Herbal extract of T.cordifolia would be one of the best options for controlling glucose concentration, enhanced immunity, and getting rid of unnecessary free radicals which increases aging. The plant under investigation is a reservoir of countless secondary metabolites.