Evaluation of anti-urolithiatic activity of Pashanabhedadi Ghrita against experimentally induced renal calculi in rats

Gupta, Sanjay; Baghel, Madhav Singh; Bhuyan, Chaturbhuja; Ravishankar, B; Ashok, B K; Patil, Panchakshari D

doi:10.4103/0974-8520.108860

Cited by 13 publications

(7 citation statements)

References 16 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Ayurveda describes a good number of formulations containing ‘ panchgavya’ components either individually as well as conjointly with other substances of herbal, mineral or animal origin. Several formulations based on each one of these five components are reported in Ayurvedic texts with medicinal claims [ [1] , [2] , [3] , [4] , [5] ].…”

Section: Introductionmentioning

confidence: 99%

Studies on Ashwagandha Ghrita with reference to murcchana process and storage conditions

Gurav

Sakharwade³

2020

Journal of Ayurveda and Integrative Medicine

View full text Add to dashboard Cite

Background Withania somnifera (L.) (family-Solanaceae), known as ‘Indian ginseng’ or ‘ Ashwagandha ’ is acclaimed as an effective adaptogen, immunomodulator, aphrodisiac and sedative. Ashwagandha ghrita is a recognized ghee based Ayurvedic formulation. Few ancient texts suggest murcchana process for preparation of Ashwagandha ghrita . Objective The study was undertaken to evaluate probable effects of murcchana process on ghrita preparation with reference to time and storage conditions. Materials and Methods Ashwagandha ghrita samples were prepared separately using plain ghee (Indian cow's ghee) and murcchana ghee. These formulations were stored separately in different glass bottles at room temperature and 400C/75%RH. Organoleptic characters (colour, odour, taste, texture and touch) and physicochemical parameters (acid value, peroxide value, iodine value, saponification value, unsaponifiable matter, refractive index and specific gravity) were determined after 3, 6, 9 and 12 months. Plain ghee and prepared ghrita were subjected for antioxidant evaluation by various in vitro methods. Results Changes were observed in organoleptic characters and physicochemical parameters of plain ghee and Ashwagandha ghrita formulations. Alterations in these parameters were more pronounced at high temperature and on long storage. Ashwagandha ghrita prepared with murcchana process exhibited better antioxidant potential in all in vitro methods. Conclusion The murcchana process was found to be beneficial towards quality of ghrita. Hence, Ashwagandha ghrita may be prepared along with murcchana herbs and stored in a good quality glass bottle to ensure improved shelf life of ghrita .

show abstract

Section: Introductionmentioning

confidence: 99%

Studies on Ashwagandha Ghrita with reference to murcchana process and storage conditions

Gurav

Sakharwade³

2020

Journal of Ayurveda and Integrative Medicine

View full text Add to dashboard Cite

show abstract

“…Restoration of the balance between urinary stone promoters (calcium, oxalate, uric acid, phosphate) and inhibitors (citrate and magnesium) needs to be attained by the intended antiurolithiatic agent as the imbalance contributes to lithiasis [38] . Besides this, raising the urine volume, pH and anticalcifying activity, enhancing renal function and oxalate metabolism, lessening the oxidative stress on renal tissues are other mechanisms exhibited by medicinal herbs for alleviating the incidence of calculi [39] .…”

Section: Resultsmentioning

confidence: 99%

In vitro Inhibition of Calcium Oxalate Nucleation by Extract-based Fractions of Aerial Parts and Roots of Aerva lanata (Linn.) Juss. ex Schult

Mandal¹,

Madan²,

Ahmad³

2017

pharmaceutical-sciences

View full text Add to dashboard Cite

The current investigation is an attempt to explore the comparative in vitro antiurolithic potential of various phytoconstituent-rich fractions derived from the hydroalcoholic extract of aerial parts and roots of Aerva lanata (Linn.) Juss. ex Schult (Amaranthaceae). The antiurolithic assay was performed by nucleation method. The analysis revealed the phenolic and flavonoid containing fraction from aerial parts to be the most active (71.01±1.13 %) amongst the different extract-derived fractions compared to the one obtained from roots (54.61±2.30 %). Besides, fluorescence analysis and physicochemical evaluation were carried out according to the official guidelines and supported the quality control of the plant material. Preliminary phytochemical screening of the fractions was also performed and confirmed the presence of various metabolites. Additionally, the content of tannins, total phenolics and flavonoids were also determined spectrophotometrically and found to be comparatively higher in aerial parts (tannin content of 4.34±0.63 mg tannic acid equivalent/g extract, total phenolic content of 127.84±1.50 gallic acid equivalent/g extract and total flavonoid content of 77.61±3.78 rutin equivalent/g extract) than roots (tannin content of 3.03±0.63 mg tannic acid equivalent/g extract, total phenolic content of 98.09±1.10 gallic acid equivalent/g extract and total flavonoid content of 62.81±5.69 rutin equivalent/g extract). Hence, the present study aids in screening out the best active extract derived fraction exerting litholytic efficacy, which provides a route to further isolation of lead bioactive compounds contributing to significant antiurolithic potency of this traditionally employed herb of immense pharmacological spectrum.

show abstract

“…Antiurolithiatic activity has been studied in plants [11,12]. Validation of herbal drugs is the requirement of time through the experimental study [13].…”

Section: Introductionmentioning

confidence: 99%

Study of antiurolithiatic activity of a formulated herbal suspension.

Saxena¹,

Argal²

2015

Herba Polonica

View full text Add to dashboard Cite

S u m m a r yUrolithiasis is the process of formation of stone in the urinary tract by crystal nucleation, aggregation and retention in the urinary tract. Traditional medicinal plants have been successfully used to overcome urolithiasis. Hence, herbal formulation containing a mixture of plant extracts was prepared and evaluated for the antiurolithiatic activity. This formulation contained alcoholic extracts of fruit of Tribulus terrestris, root of Boerhavia diffusa and leaves of Azadirachta indica . Studies were performed in ethylene glycol-induced urolithiasis model using Cystone as a standard drug. Ethylene glycol increases the level of calcium, oxalate and phosphate which are responsible for urolithiasis. The herbal suspension decreased the level of calcium, oxalate and phosphate significantly at doses of 200 and 300 mg/kg when compared to the negative control group. Creatine, uric acid and urea were also decreased significantly at all dose levels. Histopathology has supported these results. The level of LD 50 was found to be higher than 2000 mg/kg. Therefore, the prepared formulation has appreciable significant antiurolithiatic activity and is safe for use.

show abstract

Evaluation of anti-urolithiatic activity of Pashanabhedadi Ghrita against experimentally induced renal calculi in rats

Cited by 13 publications

References 16 publications

Studies on Ashwagandha Ghrita with reference to murcchana process and storage conditions

Studies on Ashwagandha Ghrita with reference to murcchana process and storage conditions

In vitro Inhibition of Calcium Oxalate Nucleation by Extract-based Fractions of Aerial Parts and Roots of Aerva lanata (Linn.) Juss. ex Schult

Study of antiurolithiatic activity of a formulated herbal suspension.

Contact Info

Product

Resources

About