Evaluation of anti-vector immune responses to adenovirus-mediated lung gene therapy and modulation by αCD20

Clark, Robert D.E.; Rabito, Felix; Munyonho, Ferris T.; Remcho, T. Parks; Kolls, Jay K.

doi:10.1016/j.omtm.2024.101286

Molecular Therapy - Methods & Clinical Development

2024

DOI: 10.1016/j.omtm.2024.101286

|View full text |Cite

Evaluation of anti-vector immune responses to adenovirus-mediated lung gene therapy and modulation by αCD20

Robert D.E. Clark,

Felix Rabito,

Ferris T. Munyonho

et al.

Help me understand this report

Search citation statements

Order By: Relevance

Paper Sections

Select...

Citation Types

Supporting

Mentioning

Contrasting

Year Published

2024

Publication Types

Select...

Article1

Relationship

Self Cite0

Independent1

Authors

Journals

Cited by 1 publication

References 72 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

Strategies for Modifying Adenoviral Vectors for Gene Therapy

Muravyeva,

Smirnikhina

2024

IJMS

View full text Add to dashboard Cite

Adenoviral vectors (AdVs) are effective vectors for gene therapy due to their broad tropism, large capacity, and high transduction efficiency, making them widely used as oncolytic vectors and for creating vector-based vaccines. This review also considers the application of adenoviral vectors in oncolytic virotherapy and gene therapy for inherited diseases, analyzing strategies to enhance their efficacy and specificity. However, despite significant progress in this field, the use of adenoviral vectors is limited by their high immunogenicity, low specificity to certain cell types, and limited duration of transgene expression. Various strategies and technologies aimed at improving the characteristics of adenoviral vectors are being developed to overcome these limitations. Significant attention is being paid to the creation of tissue-specific promoters, which allow for the controlled expression of transgenes, as well as capsid modifications that enhance tropism to target cells, which also play a key role in reducing immunogenicity and increasing the efficiency of gene delivery. This review focuses on modern approaches to adenoviral vector modifications made to enhance their effectiveness in gene therapy, analyzing the current achievements, challenges, and prospects for applying these technologies in clinical practice, as well as identifying future research directions necessary for successful clinical implementation.

show abstract

Strategies for Modifying Adenoviral Vectors for Gene Therapy

Muravyeva,

Smirnikhina

2024

IJMS

View full text Add to dashboard Cite

show abstract

scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.

Contact Info

customersupport@researchsolutions.com

10624 S. Eastern Ave., Ste. A-614

Henderson, NV 89052, USA

This site is protected by reCAPTCHA and the Google Privacy Policy and Terms of Service apply.

Blog Terms and Conditions API Terms Privacy Policy Contact Cookie Preferences Do Not Sell or Share My Personal Information

Made with 💙 for researchers

Part of the Research Solutions Family.

Evaluation of anti-vector immune responses to adenovirus-mediated lung gene therapy and modulation by αCD20

Cited by 1 publication

References 72 publications

Strategies for Modifying Adenoviral Vectors for Gene Therapy

Strategies for Modifying Adenoviral Vectors for Gene Therapy

Contact Info

Product

Resources

About