Evaluation of antibacterial activity of crude extracts of ascidian Didemnum psammathodes Sluiter, 1895 against isolated human and fish pathogens

Kumaran, N. Sri; Bragadeeswaran, S.; Meenakshi, V. K.

doi:10.1016/s2221-1691(11)60132-9

Cited by 8 publications

(1 citation statement)

References 17 publications

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“…Examples of these secondary metabolites include alkaloids (Davis et al 1999;Oku et al 2000), lipids (Mitchell et al 2000), peptides (Rudi et al 2003;Toshiaki et al 2008) and macrolides (Potts & Faulkner 1991;Pika & Faulkner 1995). Many of the isolated compounds were found to possess significant biological activities including antiplasmodial (Wright et al 2002), antibacterial (Kumaran et al 2011), antiviral (Davis et al 1999), cytotoxic (Segraves et al 2003) and antileukaemic (Takeara et al 2008). Previous investigation of the Red Sea Didemnum species led to the isolation of two new spiroketals, didemnaketals D and E (Mohamed et al 2014).…”

Section: Introductionmentioning

confidence: 99%

Didemnacerides A and B: two new glycerides from Red Sea ascidian Didemnum species

Ibrahim

Mohamed

Shaala

et al. 2014

Natural Product Research

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Two new glycerides, didemnacerides A (1) and B (2), together with three known sterols, 24-ethyl-25-hydroxycholesterol (3), cholest-6-en-3,5,8-triol (4) and cholestane-3β,5α,6β-26-tetrol (5), were isolated from the Red Sea ascidian Didemnum sp. Their structures were elucidated by using extensive 1D ((1)H, (13)C) and 2D ((1)H-(1)H COSY, HSQC and HMBC) NMR studies and mass spectroscopic data (GC-MS and HR-MS) as well as alkaline hydrolysis followed by GC-MS and NMR spectral analyses of the fatty acid methyl esters. This is the first report of compounds 3-5 from the Red Sea ascidian Didemnum species.

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