Evaluation of Antibacterial, Anti-Oxidant and Cytotoxic Activity of Organic Extracts of Mahogany Seeds

Abstract

The perception of normal medicine is changing, and the use of traditional or herbal medicine increasing worldwide due to our harmonious nature of the biological system. Many parts of the plants possess an impressive array of medicinal benefits, mahogany seed is one of them. The aim of this study is to evaluate the antimicrobial, anti-oxidant and cytotoxic activity of organic extracts of mahogany seeds. For determination of antimicrobial and cytotoxic activity disk diffusion and brine shrimp lethality bioassay were used. DPPH free radical test were performed for evaluation of antioxidant activity. Ethanol, n-hexane and aqueous extracts were examined with the total number of 10 bacterial strain. Here, ethanol extract showed higher antimicrobial activity than n-hexane and aqueous extract for both gram positive and negative bacteria. In brine shrimp lethality bioassay LC50 values were 82 μg/ml, 95 μg/ml and 93 μg/ml for ethanol, n-hexane and aqueous extracts respectively. The scavenging DPPH free radicals were found to be concentration dependent. The LC50 value was measured at 140µg/ml, 160µg/ml and 180µg/ml for ethanol, n-hexane and aqueous extract. The results of this study indicated that the mahogany seeds can be used as an easily accessible source of natural antioxidants and Cytotoxic compounds which might be helpful in preventing the progress of various oxidative stresses and cell culture assay.

A Systematic Review on the Hypoglycemic Potentials of Mahogany (Swietenia spp.) Seeds as Antioxidants in the Management of Gestational Diabetes Mellitus

“…Among all the samples, the ethanol extract showed the lowest LC50 value. 16 The MDA levels in the normal and hyperglycemic rats were 14.58 mg/dL and 16.87 mg/dL, respectively. After administration of methanol extract, acetone extract, water extract, and S. macrophylla oil, MDA levels were 15.45 mg/dL, 16.22 mg/dL, 15.78 mg/dL, and 15.79 mg/dl, respectively.…”

Molecular identification, characterization, and antagonistic activity profiling of Bacillus cereus LOCK 1002 along with the in-silico analysis of its presumptive bacteriocins

“…Along with B. cereus , all of these bacteriocins from different Bacillus strains can be highly important in promoting immunological feedback against pathogenic diseases [ 65 ]. Antimicrobial peptides are reported to have significant effects in suppressing microbial infections and the ROS-mediated metabolism of cancer stem cells [ 66 ], where they may be synthesized as novel AMPs for experimental applications [ 67 , 68 ].…”

Aktivitas Antibakteri Secara In Vitro Ekstrak Metanol Biji Mahoni terhadap Escherichia Coli

“…[1] Resistensi antibiotik dikaitkan dengan penggunaan berlebihan dan penyalahgunaan obat-obatan dan peresepan secara tidak rasional, serta kurangnya pengembangan obat baru oleh industri farmasi (6). Centers for Disease Control (CDC) menilai ancaman terhadap E. coli merupakan ancaman yang serius yang dapat meningkatkan dampak klinis, menyebabkan disfungsi organ, sulit dalam pengobatan sehingga membutuhkan jangka waktu yang lama, pengobatan menjadi lebih mahal, dan menyebabkan kematian (9).…”

“…Biji mahoni memiliki senyawa yang berfungsi untuk menghambat pertumbuhan bakteri, senyawa tersebut salah satunya adalah flavonoid (8). Flavonoid adalah salah satu senyawa metabolit sekunder dengan struktur polifenol yang ditemukan pada tumbuhan seperti mahoni yang terdapat pada bagian bijinya (9)(10).…”