Evaluation of Antibacterial Effect of Rosmarinus Officinalis Extract on Streptococcus Mutans in Children

Okasha, Mai; Mostafa, Mohammed; El-Araby, Salam

doi:10.21608/adjg.2021.29662.1259

Cited by 3 publications

(1 citation statement)

References 11 publications

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“…This was in agreement with [60,63,65,66,[79][80][81][82] who observed the biofilm eradication ability of many herbs including rosemary, This was attributed to the antimicrobial ability of rosemary in addition to its ability to inhibit glucan production through the inhibition of glucosyltransferase enzyme. However, the biofilm inhibitory effect of rosemary was significantly less than that of chlorhexidine which is in agreement with [83] who reported greater biofilm eradication with chlorhexidine in comparison with rosemary extract which was attributed to the broad spectrum antibacterial properties of chlorhexidine gluconate. This was a contradiction with [60] who reported higher biofilm inhibition with Rosemary compared to chlorhexidine gluconate to which it was attributed to the antibacterial potential of rosemary.…”

Section: Discussionsupporting

confidence: 90%

Effect of Rosemary Endophytic Fungal Extract on Microhardness of Enamel and Its Inhibitory Effect on Glucosyltransferase Enzyme of Streptococcus mutans- An In Vitro Study

Balbaa,

Taher,

Hamza

et al. 2024

Egyptian Dental Journal

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Background: Streptococcus mutans are involved in caries by forming biofilm polysaccharides through their glucosyl transferase enzymes. Natural plant extracts can inhibit glucosyl transferase production and bacterial activity. Endophytic fungi inside plant tissues can produce bioactive compounds similar to those produced by their host plants.Aim: Compare the inhibitory effect of rosemary endophytic fungal extract on S.mutans glucosyl transferase to rosemary and chlorhexidine and their effect on enamel microhardness. Methods: Glucosyltransferase was purified from S.mutans. The ability of the total metabolites and endophytic fungi extracted from rosemary to inhibit the purified glucosyltransferase compared to chlorhexidine and artificial saliva.13crowns of human molars were subdivided into 4 equal parts giving 4groups for microhardness and biofilm evaluation. The microhardness was evaluated at baseline and after treating the four subgroups using the rosemary extract, chlorhexidine, artificial saliva and endophytic fungal extract for 24and72h.The biofilm inhibition was tested using SEM after 24and72h.Results: Nine endophytic fungal strains were recovered from rosemary. Chaetomium globosum, Alternaria alternata and Aspergillus niger extracts showed positive inhibitory effect on glucosyltransferase 96.25%, 90.9%and81.74% respectively. While, those of rosemary extract, chlorhexidine and artificial saliva were 36.19%, 86.38%and0.27%. Chaetomium globosum extract showed the highest inhibitory effect on biofilm formation in comparison to chlorhexidine and rosemary extract after 24and72h. The highest microhardness value for all groups was at baseline then microhardness decreased after24 and72h except for Chaetomium globosum and rosemary extract where microhardness increased after72h to be higher than that after24h. Conclusion :Endophytic fungal extract of rosemary can inhibit S.mutans glucosyltransferase and its biofilm formation where it can remineralize initial carious lesions.

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Section: Discussionsupporting

confidence: 90%

Effect of Rosemary Endophytic Fungal Extract on Microhardness of Enamel and Its Inhibitory Effect on Glucosyltransferase Enzyme of Streptococcus mutans- An In Vitro Study

Balbaa,

Taher,

Hamza

et al. 2024

Egyptian Dental Journal

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Exploring the therapeutic potential of medicinal plants and their active principles in dental care: A comprehensive review

Refaey,

Abosalem,

Yasser El-Basyouni

et al. 2024

Heliyon

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Natural Anti-cariogenic Agents

Hussein

2024

Natural Conservative Dentistry: An Alternative Approach to Solve Restorative Problems

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Tooth decay is primarily caused by demineralization resulting from acids secreted by bacteria, especially Streptococcus mutans and lactobacillus, which ferment dietary carbohydrates. This occurs in plaque biofilms, which attach to the surfaces of the tooth and become laden with bacteria. Thus, over time, dental caries result from the interaction of three main contributing factors: a diet containing carbohydrates, cariesproducing bacteria, as well as sensitive tooth structure. The use of an antibacterial strategy for treating caries has evolved as a result of (1) identifying certain types of the oral microbiome as the main cariogenic flora and (2) increasing the knowledge of the specific ecology of these cariogenic florae. Combined with this concept, control, and prevention of caries have been sought by reducing the number of bacteria colonizing. Reducing bacterial populations or completely eradicating them from the oral flora would provide an additional reason to prevent dental caries. Several undesirable sideeffects of conventional antimicrobial agents include tooth discoloration and the emergence of bacterial resistance. These side effects stimulate the search for alternative natural anti-microbial agents.

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Evaluation of Antibacterial Effect of Rosmarinus Officinalis Extract on Streptococcus Mutans in Children

Cited by 3 publications

References 11 publications

Effect of Rosemary Endophytic Fungal Extract on Microhardness of Enamel and Its Inhibitory Effect on Glucosyltransferase Enzyme of Streptococcus mutans- An In Vitro Study

Effect of Rosemary Endophytic Fungal Extract on Microhardness of Enamel and Its Inhibitory Effect on Glucosyltransferase Enzyme of Streptococcus mutans- An In Vitro Study

Exploring the therapeutic potential of medicinal plants and their active principles in dental care: A comprehensive review

Natural Anti-cariogenic Agents

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