Evaluation of antibacterial properties of Barium Zirconate Titanate (BZT) nanoparticle

Abstract

So far, the antibacterial activity of some organic and inorganic compounds has been studied. Barium zirconate titanate [Ba(ZrxTi1-x)O3] (x = 0.05) nanoparticle is an example of inorganic materials. In vitro studies have provided evidence for the antibacterial activity of this nanoparticle. In the current study, the nano-powder was synthesized by sol-gel method. X-ray diffraction showed that the powder was single-phase and had a perovskite structure at the calcination temperature of 1000 °C. Antibacterial activity of the desired nanoparticle was assessed on two gram-positive (Staphylococcus aureus PTCC1431 and Micrococcus luteus PTCC1625) and two gram-negative (Escherichia coli HP101BA 7601c and clinically isolated Klebsiella pneumoniae) bacteria according to Radial Diffusion Assay (RDA). The results showed that the antibacterial activity of BZT nano-powder on both gram-positive and gram-negative bacteria was acceptable. The minimum inhibitory concentration of this nano-powder was determined. The results showed that MIC values for E. coli, K. pneumoniae, M. luteus and S. aureus were about 2.3 μg/mL, 7.3 μg/mL, 3 μg/mL and 12 μg/mL, respectively. Minimum bactericidal concentration (MBC) was also evaluated and showed that the growth of E. coli, K. pneumoniae, M. luteus and S. aureus could be decreased at 2.3, 14, 3 and 18 μg/mL of BZT. Average log reduction in viable bacteria count in time-kill assay ranged between 6 Log10 cfu/mL to zero after 24 h of incubation with BZT nanoparticle.

Effect of Synthesis Method on Antibacterial and Antibiofilm Activity Properties of BaFeO3-δ Perovskite Nanomaterials

“…Furthermore, the rst endothermic peaks for BaFeO 3 -Cop and BaFeO 3 -Sol samples at 613 and 624 K, respectively. These peaks may be due to the formation of BaFeO 3-δ perovskite while the second small endothermic peak at 650 K for BaFeO 3 -Cop sample may be due to impurity (BaO) formation which is observed in XRD and DLS results for BFO-Cop sample [14,22]. The BaFeO 3-δ perovskite phase begins to appear in BaFeO 3 -Cop sample at lower temperature than the BaFeO 3 -Sol sample because of the chemical nature of the used solvant in the precipitate [25].…”

“…The perovskite nanomaterials as antibacterial and antibio lm agent is a new and growing area in the eld of medicine because of the size of bacterial cell and its membranes are micrometers and nanometers sizes, respectively [12]. Less expensive perovskite nanomaterials were used as antibacterial agent such as SrFeO 3-δ , SrTi 1-x Fe x O 3 (x=0, 0.2, 0.4, 0.6, 0.8 and 1) and Ba(Zr x Ti 1-x )O 3 (x=0.05) [10,13,14]. Abdel-Khalek et al [10] investigated the microorganisms test, antimicrobial activity as well as minimum inhibitory concentration (MIC) and minimum bactericidal concentration (MBC) of the SrFeO 3-δ nanoparticles sample.…”

Preconcentration of morphine in urine sample using a green and solvent-free microextraction method

“…Moreover, a comprehensive global effort has been recently started to reduce hazardous wastes of chemical origin in addition to developing economical, cost-effective, and safe method for analysis of chemicals and toxicants in the reference laboratories as well as in clinical practices for diagnostic purposes [13]. In addition, to overcome the disadvantages of routine microextraction technique, recent studies have focused on developing green methods with the lowest solvent use as possible using biocompatible nanomaterials [14]. For this reason, plant extracts or other purified herbal products are the era of interest for many researchers in green chemistry or diagnostic medicine, and recent findings showed that herbal products or plant extract can be used at different stages of method development [15,16].…”

The Effect of Green Gold Nanoparticles Synthesized with the Achillea millefolium Extract on the Morphometric and Developmental Indices of Preantral Follicles in Immature NMRI Mice

“…Nanotechnology is an interdisciplinary science that links different scientific fields, including medical and pharmaceutical technology, physics, engineering, and chemistry (1). Nanoparticles (NPs) are small-sized particles with typical dimensions of 1 -100 nm (2,3). Due to the small size of NPs, they can interact with a variety of biomolecules, including proteins and nucleic acids (4).…”