Evaluation of antibiotic stewardship among near-term and term infants admitted to a neonatal unit

Feng, Kun; Liu, Weiqin; Zhang, Xinyin; Song, Ping; Hua, Ziyu

doi:10.1007/s00431-022-04668-5

Cited by 4 publications

(2 citation statements)

References 25 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In this classification, PVG was defined on presence of an abdominal radiograph, not ultrasound. Stages 1, 2, and 3 indicate “suspected necrotizing enterocolitis,” “definite necrotizing enterocolitis,” and “advanced necrotizing enterocolitis,” respectively 28–30 …”

Section: Methodsmentioning

confidence: 99%

See 1 more Smart Citation

Association between the dynamic movement of hyperechoic foci and patients'/sonographic outcomes among pediatric patients with portal venous gas following a cardiac event

Hosokawa

Tanami

Sato

et al. 2023

J of Clinical Ultrasound

View full text Add to dashboard Cite

Objectives To demonstrate the association between the dynamic movements of hyperechoic foci in portal venous gas (PVG) and patients'/sonographic outcomes after congenital heart disease or cardiac events. Methods Thirty‐one pediatric patients requiring management of congenital heart diseases or cardiac events who had PVG on ultrasound were included in this retrospective study. The patient outcome was prognosis: dead or alive. The sonographic outcome was recovery from PVG, measured as days from PVG detection to when it diminished on ultrasound. The following sonographic findings of hyperechoic foci in PVG were compared between patients: detection within the mesenteric vein, having to‐and‐fro movements within the intrahepatic portal vein, distribution (left segment or both left and right segments) and shape (line or punctate) in the liver, and detection within the portal and hepatic veins. Comparisons were made using Fisher's exact/Mann–Whitney U test. Results Four patients died without having recovered from PVG. A significant difference was observed in terms of the to‐and‐fro movement (with/without to‐and‐fro movement in dead vs. alive patients: 3/1 vs. 1/26, respectively; P = 0.003). Furthermore, a significant difference in sonographic outcomes was observed regarding patients with/without hyperechoic foci within the mesenteric vein (days with vs. without this finding: 2.0 ± 1.24(1–5) vs.1 ± 0(1), respectively; P = 0.011). Conclusions In our small limited cohort, when PVG was visualized on ultrasound, close evaluation of the dynamic movement of hyperechoic foci, especially their to‐and‐fro movement within the intrahepatic portal vein and detection of hyperechoic foci within the mesenteric vein, were useful in predicting patients' outcomes and the time to PVG diminishment.

show abstract

Section: Methodsmentioning

confidence: 99%

“…Stages 1, 2, and 3 indicate "suspected necrotizing enterocolitis," "definite necrotizing enterocolitis," and "advanced necrotizing enterocolitis," respectively. [28][29][30]…”

Section: Clinical Classificationmentioning

confidence: 99%

Association between the dynamic movement of hyperechoic foci and patients'/sonographic outcomes among pediatric patients with portal venous gas following a cardiac event

Hosokawa

Tanami

Sato

et al. 2023

J of Clinical Ultrasound

View full text Add to dashboard Cite

show abstract

Verantwortungsvoller Antibiotikaeinsatz auf der Neugeborenenintensivstation

2023

Neonatologie Scan

View full text Add to dashboard Cite

Prevention and Treatment of Neonatal Infections in Facility and Community Settings of Low- and Middle-Income Countries: A Descriptive Review

Lee Him,

Rehman,

Sihota

et al. 2024

Neonatology

View full text Add to dashboard Cite

Introduction: We present a robust and up-to-date synthesis of evidence on the effectiveness of interventions to prevent and treat newborn infections in low- and middle-income countries (LMICs). Newborn infection prevention interventions included strategies to reduce antimicrobial resistance (AMR), prevention of healthcare-associated infections (HAIs), clean birth kits (CBKs), chlorhexidine cleansing, topical emollients, and probiotic and synbiotic supplementation. Interventions to treat suspected neonatal infections included prophylactic systemic antifungal agents and community-based antibiotic delivery for possible serious bacterial infections (PSBIs). Methods: A descriptive review combining different methodological approaches was conducted. To provide the most suitable recommendations for real-world implementation, our analyses considered the impact of these interventions within three distinct health settings: facility, mixed, and community. Results: In facility settings, the strongest evidence supported the implementation of multimodal stewardship interventions for AMR reduction and device-associated infection prevention bundles for HAI prevention. Emollients in preterm newborns reduced the risk of invasive infection compared to routine skin care. Probiotics in preterm newborns reduced neonatal mortality, invasive infection, and necrotizing enterocolitis (NEC) risks compared to standard care or placebo. There was insufficient evidence for synbiotics and prophylactic systemic antifungals in LMICs. In mixed settings, CBKs reduced neonatal mortality risk compared to standard care. In community settings, chlorhexidine umbilical cord cleansing reduced omphalitis risk compared to dry cord care. For the treatment of PSBIs, purely domiciliary-based antibiotic delivery reduced the risk of all-cause neonatal mortality when compared to the standard hospital referral. Conclusion: Strategies for preventing HAIs and reducing AMR in healthcare facilities should be multimodal, and strategy selection should consider the feasibility of integration within existing newborn care programs. Probiotics are effective for facility-based use in preterm newborns; however, the establishment of high-quality, cost-effective mass production of standardized formulations is needed. Chlorhexidine cord cleansing is effective in community settings to prevent omphalitis in contexts where unhygienic cord applications are prevalent. Community-based antibiotic delivery of simplified regimens for PSBIs is a safe alternative when hospital-based care in LMICs is not possible or is declined by parents. More randomized trial evidence is needed to establish the effectiveness of CBKs, emollients, synbiotics, and prophylactic systemic antifungals in LMICs.

show abstract

Evaluation of antibiotic stewardship among near-term and term infants admitted to a neonatal unit

Cited by 4 publications

References 25 publications

Association between the dynamic movement of hyperechoic foci and patients'/sonographic outcomes among pediatric patients with portal venous gas following a cardiac event

Association between the dynamic movement of hyperechoic foci and patients'/sonographic outcomes among pediatric patients with portal venous gas following a cardiac event

Verantwortungsvoller Antibiotikaeinsatz auf der Neugeborenenintensivstation

Prevention and Treatment of Neonatal Infections in Facility and Community Settings of Low- and Middle-Income Countries: A Descriptive Review

Contact Info

Product

Resources

About