Evaluation of antibiotics resistance in Southern Iran in light of COVID‐19 pandemic: A retrospective observational study

Raoofi, Rahim; Namavari, Negin; Rahmanian, Vahid; Dousthaghi, Mohammad Hadi

doi:10.1002/hsr2.1153

Cited by 5 publications

(3 citation statements)

References 26 publications

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“…The significant increase in Gram-negative pathogens resistance to the antibiotics used in cases without other therapeutic resources, like colistin, as well as the increase in the number of PDR strains, are worrying elements for the future evolution of AMR [ 34 ]. These findings are consistent with other studies, reflecting the negative impact of COVID-19 on patients with MDR-Gram negative bloodstream infections and on AMR inside ICU settings [ 25 , 35 ].…”

Section: Discussionsupporting

confidence: 93%

“…against ceftazidime, colistin, and doxycycline, in the post-COVID-19 period compared to the pre-COVID-19 period. Another study, conducted in a COVID-19 referral hospital in Iran, showed a significant overall resistance increase among Gram-negative bacteria, particularly P. aeruginosa and K. pneumoniae [ 25 ]. A review conducted by Khaznadar et al also revealed that Gram-negative pathogens were those with levels of antimicrobial resistance most affected by the overuse of antibiotics during the pandemic [ 26 ], while a retrospective study conducted in Greece showed an increasing trend in the incidence of resistant Gram-negative bacteria, particularly in ICUs, compared to the pre-pandemic period [ 27 ].…”

Section: Discussionmentioning

confidence: 99%

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Pre- and Post-COVID-19 Antimicrobial Resistance Pattern of Pathogens in an Intensive Care Unit

Golli,

Zlatian,

Cara

et al. 2024

Pharmaceuticals

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We aimed to determine the trend of the antimicrobial resistance pattern of pathogens isolated in samples collected from patients hospitalized in the intensive care unit (ICU) in selected periods before and after COVID-19. A retrospective study of bacterial pathogens was performed on 1267 patients. Positive bacterial culture data from 1695 samples from the pre-COVID-19 period and 1562 samples from the post-COVID-19 period were obtained. The most frequently isolated bacteria in both periods were Staphylococcus aureus and Klebsiella spp. The resistance rates of Klebsiella spp. Significantly increased against colistin (0.38% to 20.51%), gentamicin (44.62% to 64.85%), and aztreonam (56.35% to 3.60%). There was a significant increase in the resistance rate against colistin for E. coli strains (4.69% to 32.46%) and for Acinetobacter sp. strains (3.37% to 18.09%). More than 50% of the Staphylococcus aureus strains were MRSA, with statistically significant increases in the antimicrobial resistance rate against doxycycline (40.08% to 51.72%), linezolid (0.22% to 3.13%), rifampicin (53.16% to 64.93%), and teicoplanin (26.31% to 53.40%). The study revealed a significantly increasing trend in the antimicrobial resistance rate of Gram-negative pathogens against certain antibiotics, including those used only in cases where there are no other therapeutic options.

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Section: Discussionsupporting

confidence: 93%

Section: Discussionmentioning

confidence: 99%

Pre- and Post-COVID-19 Antimicrobial Resistance Pattern of Pathogens in an Intensive Care Unit

Golli,

Zlatian,

Cara

et al. 2024

Pharmaceuticals

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“…Raoofi et al demonstrated the increase in AMR among Gram-negative bacteria in a retrospective observational study in Southern Iran. Particularly, the average change rate of PA (89%) and Klebsiella pneumonia (66.3%) resistance for the reported antibiotics was observed during the COVID-19 pandemic compared to the pre-pandemic [ 41 ]. Another retrospective study from April 2019 to April 2021, conducted in an adult ICU at the Hospital for Infectious and Tropical Diseases, Belgrade, Serbia, emerged as COVID-19 changed the landscape of HAIs (HAIs) in intensive care units (ICUs) [ 22 ].…”

Section: Discussionmentioning

confidence: 99%

Antimicrobial Resistance in Pseudomonas aeruginosa before and during the COVID-19 Pandemic

et al. 2023

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Pseudomonas aeruginosa (PA) is a major Gram-negative opportunistic pathogen causing several serious acute and chronic infections in the nosocomial and community settings. PA eradication has become increasingly difficult due to its remarkable ability to evade antibiotics. Therefore, epidemiological studies are needed to limit the infection and aim for the correct treatment. The present retrospective study focused on PA presence among samples collected at the San Giovanni di Dio and Ruggi D’Aragona University Hospital in Salerno, Italy; its resistance profile and relative variations over the eight years were analyzed. Bacterial identification and antibiotic susceptibility tests were performed by VITEK® 2. In the 2015–2019 and 2020–2022 timeframes, respectively, 1739 and 1307 isolates of PA were obtained from respiratory samples, wound swabs, urine cultures, cultural swabs, blood, liquor, catheter cultures, vaginal swabs, and others. During 2015–2019, PA strains exhibited low resistance against amikacin (17.2%), gentamicin (25.2%), and cefepime (28.3%); moderate resistance against ceftazidime (34.4%), imipenem (34.6%), and piperacillin/tazobactam (37.7%); and high resistance against ciprofloxacin (42.4%) and levofloxacin (50.6%). Conversely, during the 2020–2022 era, PA showed 11.7, 21.1, 26.9, 32.6, 33.1, 38.7, and 39.8% resistance to amikacin, tobramycin, cefepime, imipenem, ceftazidime, ciprofloxacin, and piperacillin/tazobactam, respectively. An overall resistance-decreasing trend was observed for imipenem and gentamicin during 2015–2019. Instead, a significant increase in resistance was recorded for cefepime, ceftazidime, and imipenem in the second set of years investigated. Monitoring sentinel germs represents a key factor in optimizing empirical therapy to minimize the spread of antimicrobial resistance.

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Assessment of antibiotic resistance patterns in Central Taiwan during the COVID-19 pandemic: A retrospective study

Tseng,

Huang,

Chen

et al. 2024

Journal of Infection and Public Health

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Evaluation of antibiotics resistance in Southern Iran in light of COVID‐19 pandemic: A retrospective observational study

Cited by 5 publications

References 26 publications

Pre- and Post-COVID-19 Antimicrobial Resistance Pattern of Pathogens in an Intensive Care Unit

Pre- and Post-COVID-19 Antimicrobial Resistance Pattern of Pathogens in an Intensive Care Unit

Antimicrobial Resistance in Pseudomonas aeruginosa before and during the COVID-19 Pandemic

Assessment of antibiotic resistance patterns in Central Taiwan during the COVID-19 pandemic: A retrospective study

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