Evaluation of Anticancer Activity of Schiff bases Derived from Pyridine and their Metal Complexes- A Review

Abstract

Cancer is a deadly disease; many treatment strategies are available to cure/ treat cancer. After the metal-based anticancer drug (Cisplatin), metal complexes play a vital role in pharmaceutical science. We aimed to analyze the anticancer activity of pyridine Schiff base complexes. This review article searched the anticancer studies of pyridine Schiff base metal complexes from 2015 to 2021. Information was gathered from the selected studies to analyze and highlight the importance of anticancer agents. A total of sixty six full-length articles were collected and evaluated. On the critical assessment, we found that compared to Schiff base ligand, the metal complexes exhibited excellent activity towards various cancer cell lines (including MCF-7, HeLa, HCT-116, Hepa-2).We identified more complexes that exhibited promising activity against various cell lines and revealed IC50 values equal to or even lower than the reference drug used.

Chemistry with Schiff Bases of Pyridine Derivatives: Their Potential as Bioactive Ligands and Chemosensors

“…Due to their biological activities and clinical usage, they are of worth attention. Their successful application can lead to the formation of series of novel compounds with wide range of physical, chemical and biological activities [28][29][30][31][32][33].…”

Synthesis, IR, and NMR Study of Some Cu(II), Ni(II), Co(II) Complexes of O-Vanillin and 2- Amino Pyridine.

“…17 There is a shortage of research on o-vanillin, the Schiff base that contains o-vanillin moiety forms stable complexes with several metal ions. Therefore ortho vanillin is the ideal contender in the synthesis of different aromatic Schiff bases [18][19] .…”