Evaluation of anticancer properties of a decoction containing Adenanthera pavonina L. and Thespesia populnea L.

Lindamulage, Indeewari K. S.; Soysa, Preethi

doi:10.1186/s12906-016-1053-9

Cited by 14 publications

(11 citation statements)

References 33 publications

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“…On the other hand, the ethanol extract showed low growth inhibition against all the cancer cell lines. Lindamulage and Soysa (2016) observed that a decoction prepared with barks of A. pavonina and Thespesia populnea in equal proportion, exhibited antiproliferative activity and induced apoptosis in the Hep-2 cancer cells, 24 h post-treatment. Araujo et al (2019) evaluated the influence of antiproliferative activity against cancer cells of A. panonina seed powder treated enzymatically with amylase, cellulase, and protease.…”

Section: Anticancer Activitymentioning

confidence: 99%

“…According to the literature, this plant was used in ancient Indian medicine, where crushed seeds were used to treat boils and inflammations (Olajide et al, 2004). In general, the literature reports its empirical use for diabetes, lipid disorders, diarrhea, ulcers, stomach bleeding, hematuria, rheumatism, asthma, hypertension, pulmonary infections and chronic ophthalmia (Pandhare et al, 2012a;Zeid et al, 2012;Mujahid et al, 2013;Godoi et al, 2014;Moniruzzaman et al, 2015;Dissanayake et al, 2018) and cancer (Lindamulage and Soysa, 2016). Zeid et al (2012) reported its use as a tonic.…”

Section: Ethnomedicinal Usementioning

confidence: 99%

“…In the literature, there are some reports on the traditional use of A. pavonina derivatives to the treatment of cancer (Lindamulage and Soysa, 2016). Some in vitro assays have shown the anticancer activity of plant derivatives.…”

Section: Anticancer Activitymentioning

confidence: 99%

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Advances in the research of Adenanthera pavonina: From traditional use to intellectual property

GeronÃ§o¹,

Melo²,

Barros³

et al. 2020

J. Med. Plants Res.

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Adenanthera pavonina, an Asian native leguminous, is a well known highly used plant in traditional medicine. Such broad herbal medicine applications motivated several researchers to study its chemical composition, mainly of its leaves, seeds, and barks, besides the pharmacological effects aiming to demonstrate scientific evidence of its empirical uses. Most studies have been conducted with plant derivatives, and more recent studies have focused on isolated compounds. The phytochemical screening revealed various secondary metabolites with diverse biological effects, including flavonoids, alkaloids, saponins, tannins, steroids, triterpenoids, polyphenols, anthraquinones, coumarins, glycosides and polysaccharides. Experimental studies of this plant have shown numerous pharmacological activities such as antidiarrheal, anti-inflammatory, antinociceptive, antioxidant, antimicrobial, anticancer, and others. Advances in the studies of phytochemistry and biological activity on this plant species over the last years led to the increasing interest of researchers in the protection of inventions focusing on its cosmetic, pharmaceutical and food applicability. This review summarizes the tremendous therapeutic and technological potential of A. pavonina that should be explored, opening new perspectives for future researches and the development of new products.

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Section: Anticancer Activitymentioning

confidence: 99%

Section: Ethnomedicinal Usementioning

confidence: 99%

See 1 more Smart Citation

Advances in the research of Adenanthera pavonina: From traditional use to intellectual property

GeronÃ§o¹,

Melo²,

Barros³

et al. 2020

J. Med. Plants Res.

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show abstract

“…Sus resultados se interpretan dependiendo del contexto en que se plantea el objetivo de la investigación, si la sustancia evaluada no es citotóxica es un indicador que esta sustancia puede ser bien tolerada por un sistema biológico, y si la sustancia es citotóxica es un indicador que esta sustancia puede contener compuestos bioactivos con potencial efecto antitumoral (9) . Es importante señalar que un estudio desarrollado por el National Cancer Institute de los Estados Unidos mostró que existe una fuerte correlación entre la prueba de letalidad de Artemia salina, y la inhibición del crecimiento in vitro en líneas celulares de tumores sólidos humanos (10) ; estos resultados han servido para que, actualmente, varios estudios utilicen esta prueba para establecer un mecanismo de selección preliminar de especies vegetales con potencial anticancerígeno (11,12) .…”

Section: Introductionunclassified

Evaluación de la bioactividad de plantas medicinales cultivadas en el Perú usando la prueba de letalidad de Artemia salina

Aranda-Ventura¹,

Villacrés-Vallejo²,

Núñez-Tuesta³

et al. 2019

Rev. per. med. integr.

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Objetivo. Determinar la bioactividad de trece plantas medicinales peruanas a través de su capacidad citotóxica. Materiales y métodos. Se elaboraron extractos acuosos, hidroalcohólicos, o zumos liofilizados de las especies vegetales seleccionadas. La citotoxicidad in vitro fue evaluada usando la prueba de letalidad de Artemia salina, con la determinación de la concentración letal media (CL50). El potencial citotóxico de las muestras de extractos evaluados, se clasificaron en: a) no tóxico: CL50 > 1000 μg/ mL; b) baja toxicidad: 500 < CL50 ≤ 1000 μg/ mL; c) toxicidad moderada: 100 < CL50 ≤ 500 μg/ mL, y d) alta toxicidad: CL50 < 100 μg/ mL. Resultados. Los diferentes extractos del rizoma de Curcuma longa mostraron una potente actividad citotóxica, con CL50 entre 20,67 ± 7,04 y 98,14± 2,64 ug/mL. Los extractos de rizoma de Zingiber officinale, del fruto de Physalis angulata y la planta entera de Physalis angulata también mostraron actividad citotóxica con CL50 de 87,15±18,17, 323,48±18,85y 328,92±23,08 ug/mL, respectivamente. Conclusión. Se encontró actividad citotóxica en losextractos de los rizomas de Curcuma longa, Zingiber officinale, así como el fruto y planta entera dePhysalis angulata. Futuros estudios podrán determinar si la flora cultivada en el Perú puede ser unafuente para el desarrollo futuro de agentes antitumorales.

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“…Up to now, Africa still provides a non-negligible contribution to overall complementary and alternative medicines despite the fact that traditional medical practitioners have been using crude drug extracts for several years [ 1 – 4 ]. Thus, there is rationale in investigating herbal toxicity within the African health care system [ 5 , 6 ], given that a sizable part of our population regularly use them.…”

Section: Introductionmentioning

confidence: 99%

Safety evaluation of Bon-santé cleanser® polyherbal in male Wistar rats

Kale

Awodele

2016

BMC Complement Altern Med

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BackgroundThe potential harm of medicinal herbs has been recently observed following herbal toxicity studies after ingestion of polyherbal remedies. This was the rationale for the food and drug regulatory agency decision for thorough safety evaluation of herbal medicines. Androgenic, antipyretic, analgesic and anti-inflammatory potentials as well as chemical compositions of extracts of massularia acuminata, terminalia ivorensis, anogeissus leiocarpus and macuna pruriens respectively have been documented. Thus, Bon-santé cleanser® (BSC) is formulated from these medicinal plants with the intention to boost body hormones and energizes the body. Considering the wide usage of BSC, we investigated on its safety in male Wistar rats.MethodsThirty-two male Wistar rats weighing 201.9 ± 7.5 g were grouped into four treatment groups of eight per group. Group I, (control) received distilled water (10 ml/kg). Groups II-IV received 250 mg/kg, 500 mg/kg and 1000 mg/kg of BSC per oral respectively. Each group was treated for sixty days.ResultsAcute toxicity test, in male Wistar albino mice, showed that LD50 was 600 mg/kg via i.p. while 4 g/kg was nonlethal after oral administration in mice. Hepatic and renal biomarker enzymes were unaltered in all rats. Increased in PCV (p <0.05) was observed at 500 mg/kg. BSC modulates antioxidants biomarkers following sub-chronic administration and increased serum Na+ (p >0.05). BSC at 1000 mg/kg caused mild inflammation of the liver and heart but not kidneys histologically.ConclusionsBSC has been found to be relatively safe in Wistar rats. Although, our findings indicate that herbal therapy with BSC should be done with caution as a mild alteration in the liver and heart architectures were observed.

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Evaluation of anticancer properties of a decoction containing Adenanthera pavonina L. and Thespesia populnea L.

Cited by 14 publications

References 33 publications

Advances in the research of Adenanthera pavonina: From traditional use to intellectual property

Advances in the research of Adenanthera pavonina: From traditional use to intellectual property

Evaluación de la bioactividad de plantas medicinales cultivadas en el Perú usando la prueba de letalidad de Artemia salina

Safety evaluation of Bon-santé cleanser® polyherbal in male Wistar rats

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