Evaluation of anticataract potential of Triphala in selenite-induced cataract: In vitro and in vivo studies

Gupta, Suresh; Kalaiselvan, V; Srivastava, Sushma; Agrawal, S.; Saxena, Ruchi

doi:10.4103/0975-9476.74425

Cited by 40 publications

(28 citation statements)

References 22 publications

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“…In lenses from Groups III, IV, and V, which were pretreated with curcumin, CD1, and CD2, respectively, along with selenite, the SOD, and Ca 2+ ATPase activities were similar to control groups (Figure 3 and Table 2), indicating a complete reversal of selenite‐induced cataract. Our results are in agreement with the earlier reports (29–35).…”

Section: Discussionsupporting

confidence: 94%

Bioactive Derivatives of Curcumin Attenuate Cataract Formation In Vitro

et al. 2012

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In this study, curcumin derivatives salicylidenecurcumin (CD1) and benzalidenecurcumin (CD2)] were prepared, and their biological activity was compared in in vitro selenite-induced cataract model. The antioxidant activity was studied using DPPH radical scavenging assay. Knoevenagel condensates of curcumin exhibited higher DPPH radical scavenging activity compared with curcumin. The anticataractogenic potential of curcumin derivatives was analyzed using lens organ culture method. The activity of antioxidant enzymes and calcium homeostasis was reversed to near normal levels following treatment in organ cultured rat lenses. These results indicated that curcumin and its derivatives-CD1 and CD2-are beneficial against selenite-induced cataract in vitro. Of these, CD1 is having higher bioactive potential compared with curcumin and CD2. Blindness is a common condition globally, affecting approximately 45 million people, and more than a third of blindness is caused by cataract (1). Approximately 25% of the population with age over 65 and about 50% over 80 have serious loss of vision because of cataract (2). Cataract is a protein aggregation disease affecting vision in humans. At present, the most effective treatment for cataract is surgical extirpation of the opaque lens, but it is expensive and not free from risk factors (3). It is widely accepted that oxidative stress is a significant factor in the genesis of cataract (4). Oxidative stress may result from an imbalance between the production of reactive oxygen species (ROS) and the cellular antioxidant defense mechanisms.Oxidative metabolism is clearly important in maintaining the lens in a transparent state. The lens is metabolically active and requires nourishment to maintain its growth and transparency. Like other organs, lens has a well-designed defense system against oxidation. It uses both enzymatic and non-enzymatic defense system to neutralize free radicals that are clearly involved in the pathophysiological changes in the eye (5). Selenite-overdose cataract is an extremely rapid and convenient model to study experimental cataract. Major events of selenite cataract are loss of calcium homeostasis, reactive oxygen species generation, and decreased water soluble proteins (6).Medicinal plants often contain highly active pharmacological compounds. Many of these compounds, isolated from a part or whole of the medicinal herbs, act as pharmaceutical drugs having therapeutic potential against cataract (7-11). Curcumin is well known for its flavoring and medical properties and shown to exhibit antioxidant, antiinflammatory, antimicrobial, and anticarcinogenic activities. The medicinal properties of curcumin are attributed to its radical scavenger activity and are shown to scavenge free radicals such as hydroxyl radicals, superoxide radicals, singlet oxygen, peroxyl radicals, and peroxynitrite (12). Thus, curcumin can reduce the oxidative stress in tissues and hence a potential candidate as an anticataract agent. In spite of its efficacy and safety, curcumin has not yet b...

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Section: Discussionsupporting

confidence: 94%

Bioactive Derivatives of Curcumin Attenuate Cataract Formation In Vitro

et al. 2012

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“…Although 50% of problems were eliminated by computer shields, other methods are still needed to minimize the vision complications. A study on the effect of computer shields showed that 81% of subjects could easily read the screen, while the prevalence of tired eyes reduced from 86% to 45%, itching and watery eyes from 50% to 28%, dry eyes from 52% to 24% and headaches from 53% to 32% (34).…”

Section: Discussionmentioning

confidence: 99%

Computer Vision Syndrome in Eleven to Eighteen-Year-Old Students in Qazvin

Khalaj¹,

Ebrahimi²,

Shojai³

et al. 2015

Biotech Health Sci

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Background: Prolonged use of computers can lead to complications such as eye strain, eye and head aches, double and blurred vision, tired eyes, irritation, burning and itching eyes, eye redness, light sensitivity, dry eyes, muscle strains, and other problems. Objectives: The aim of the present study was to evaluate visual problems and major symptoms, and their associations among computer users, aged between 11 and 18 years old, residing in the Qazvin city of Iran, during year 2010. Patients and Methods: This cross-sectional study was done on 642 secondary to pre university students who had referred to the eye clinic of Buali hospital of Qazvin during year 2013. A questionnaire consisting of demographic information and 26 questions on visual effects of the computer was used to gather information. Participants answered all questions and then underwent complete eye examinations and in some cases cycloplegic refraction. Visual acuity (VA) was measured with a logMAR in six meters. Refraction errors were determined using an auto refractometer (Potece and Heine retinoscope). The collected data was then analyzed using the SPSS statistical software. Results:The results of this study indicated that 63.86% of the subjects had refractive errors. Refractive errors were significantly different in children of different genders (P < 0.05). The most common complaints associated with the continuous use of computers were eyestrain, eye pain, eye redness, headache, and blurred vision. The most prevalent (81.8%) eye-related problem in computer users was eyestrain and the least prevalent was dry eyes (7.84%). In order to reduce computer related problems 54.2% of the participants suggested taking enough rest, 37.9% recommended use of computers only for necessary tasks, while 24.4% and 19.1% suggested the use of monitor shields and proper working distance, respectively. Conclusions: Our findings revealed that using computers for prolonged periods of time can lead to eye-related problems such as eyestrain, headaches, weak and tired eyes, blurred and double vision, weak vision, burning itching and watery eyes, etc. To correct and reduce these problems the following precautions may be helpful, using computer shields (anti-reflex glasses), proper computer workplace illumination, enough rest after working with computers, appropriate viewing distances during computer work, placing computers far from bright objects and adjusting a line of vision with the top of the monitor.

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“…Six equal parts of the homogenate were made for estimation of GSH, malondialdehyde (MDA), SOD, CAT, GPX and GSH transferase. The process followed above was modified from Gupta et al [32]. …”

Section: Methodsmentioning

confidence: 99%

Impediment of selenite-induced cataract in rats by combinatorial drug laden liposomal preparation

Huang

Muhemaitia

2018

Libyan Journal of Medicine

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Cataract is the leading cause of blindness globally with surgery being the only form of treatment. But cataract surgery is accompanied by complications, chiefly intra-ocular infections. Hence, preventive nanoformulations may be extremely beneficial. In the present study, novel chitosan-coated liposomal formulations encapsulating a combination of drugs, lanosterol and hesperetin were prepared and characterized. The combinatorial liposomes were prepared by thin film evaporation active extrusion method. The characterization of liposomes was done by transmission electron microscopy, zeta potential, encapsulation efficiency, stability, cytotoxicity and in vitro release studies. The main difference between the chitosan-coated and uncoated combinatorial liposomes is the release of drugs as indicated by the in vitro release studies. The slow and sustained release of the drugs from chitosan-coated ones as against the burst release from uncoated indicates an increased retention time for combinatorial drugs in cornea. This leads to a delay in progression of cataract as seen from in vivo studies. Cytotoxicity studies indicate no cell toxicity of the coating of chitosan or the combination of drugs. Stability studies indicate that there were almost no changes in size, zeta potential and polydispersity index values of the combinatorial liposomes upon storage at room temperature for 60 days. Another important study is the estimation of antioxidant defense system. The estimated values of glutathione reductase, malondialdehyde and chief antioxidant enzymes point toward an upregulation of antioxidant defense system. From the results, it may be concluded that novel chitosan-coated combinatorial liposomes are effective in delaying or preventing of cataract.

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Evaluation of anticataract potential of Triphala in selenite-induced cataract: In vitro and in vivo studies

Cited by 40 publications

References 22 publications

Bioactive Derivatives of Curcumin Attenuate Cataract Formation In Vitro

Bioactive Derivatives of Curcumin Attenuate Cataract Formation In Vitro

Computer Vision Syndrome in Eleven to Eighteen-Year-Old Students in Qazvin

Impediment of selenite-induced cataract in rats by combinatorial drug laden liposomal preparation

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