Evaluation of anticonvulsant activity of the ethanolic extracts from leaves of Excoecaria agallocha

Shelar, Maruti; Patil, M. J.; Bhujbal, Santosh S.; Chaudhari, R.

doi:10.1016/j.fjps.2018.06.002

Cited by 13 publications

(9 citation statements)

References 18 publications

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“…Strychnine, a competitive glycine antagonist, an inhibitory amino acid and neurotransmitter has been reported also to cause convulsion (Ishola et al, 2013). The seemingly blocking effects of plant extracts on the actions of picrotoxin and strychnine suggest that the plant may have delayed seizure latency and reduced duration of convulsion by affecting the GABAergic mechanisms and glycinergic pathways respectively (Mora-Perez et al, 2016, Murtala and Akindele 2018, Shelar et al, 2018. Based on these findings, U. afzelii can be said to possess anticonvulsant activity since it increases the seizure latency and decreases its duration.…”

Section: Discussionmentioning

confidence: 99%

EVALUATION OF THE ANTICONVULSANT ACTIVITY OF THE ETHANOL LEAF EXTRACT OF UVARIA AFZELLI Sc. Elliot (ANNONAECAE) IN MICE

Murtala

Adesina

Adeyinka

et al. 2020

AJSN

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Epilepsy is the fouth most common brain disorder in the world and about 65 million of the global population are victims. Sadly, the currently available conventional drugs are riddled with numerous side effects, expensive and have not demonstrated adequate capacity in managing this disorder. Hence, the need for safer, cheaper and more effective therapy. This study is aimed at investigating the anticonvulsant activity of the ethanol leaf extract of Uvaria afzelii. Twenty-five (25) mice were randomly allotted to five different groups of five mice each. The animals were treated orally with 100, 200 and 400 mg/kg of the extract respectively and 10 ml/kg of distilled water. The standard group received diazepam (5 mg/kg, i.m). Both strychnine (4 mg/kg, i.p) and picrotoxin (5mg/kg, i.p.) were used to induce convulsion 30 minutes post administration of extract and distilled water, and 15 minutes for standard drug. The onset and duration of convulsion for each mouse were recorded. Mice that did not convulse within 30 min of strychnine and picrotoxin injection were considered protected. The extract (400 mg/kg) significantly (P<0.01) delayed the onset of convulsion with significant reduction (P<0.05) in the duration of seizures induced by picrotoxin with 20% mortality. In the strychnine-induced test, U. afzelii (200 & 400 mg/kg) significantly delayed (p<0.001, 0.0001) the onset of convulsion with mortality of about 40%. Preliminary phytochemical screening revealed the presence of tannins, alkaloids, flavonoids, phenols and saponin. The findings in this study show that the ethanol leaf extract of Uvaria afzelii possesses anticonvulsant activity.

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Section: Discussionmentioning

confidence: 99%

EVALUATION OF THE ANTICONVULSANT ACTIVITY OF THE ETHANOL LEAF EXTRACT OF UVARIA AFZELLI Sc. Elliot (ANNONAECAE) IN MICE

Murtala

Adesina

Adeyinka

et al. 2020

AJSN

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“…prior to the induction of MES. The animals were applied with a supramaximal electrical stimulus of 150 mA for 0.2Sec through the ear electrodes [14] . The animals were observed for various phases of MES induced seizures duration of tonic hind limb flexion (THLF), tonic hind limb extension (THLE), clonus and stupors were noted.…”

Section: Screening Of Anticonvulsant Activity (I) Maximal Electroshock-induced Seizure Testmentioning

confidence: 99%

“…The present study shows that the Ethanolic extract of leaves and roots of Mirabilis jalapa may function in a similar manner to BZD, it is possible that the anticonvulsant effects might be due to significant glycinergic and GABAergic potentiating mechanisms. The Mirabilis Jalapa extracts might be inducing the release of these neurotransmitters and thus inhibiting the convulsions [14] . However, we conclude that the ethanolic extract of Mirabilis jalapa is a potent anticonvulsant agent.…”

Section: Pentylenetetrazole Induced Seizures Experimentsmentioning

confidence: 99%

Evaluation of anxiolytic and anticonvulsant potential of Mirabilis jalapa ethanolic extracts on standardized rat models

Kumar¹,

Thamotharan²,

Revathi³

et al. 2021

JUSST

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Anxiety and Convulsion are the most prominent, crippled and cruel neurological diseases in recent times. There are many indigenous plants have beneficial properties to treat mental disease and psychic complaints. Evaluation of anxiolytic and anticonvulsant activity of leaf and root ethanolic extracts of mirabilis jalapa in rat models were carried out using standardized experimental methods. The dried leaves and root was macerated with ethanol separately and administered the discern dose of 200 mg/k g p.o. and 400mg/kg p.o. from each extract and employed in Elevated Plus Maze test (EPM) and Open field test (OFT) with 2mg/kg i.p of Diazepam as a standard drug to assess the anxiolytic activity. Maximal electroshock induced convulsion (MES) (Phenytoin-20mg/kg i.p as a standard drug) and Pentylenetetrazol (PTZ) induced seizures analyzed where Diazepam (5mg/kg) i.p as a standard drug to assess the anticonvulsant activity. Substantial changes in all tested activities EPM, OFT in anxiety model and MES, PTZ in anticonvulsant model were observed. The results revealed that ethanol leaf extract (400 mg/kg p.o.) was more impetus due to the high amount of flavonoid, phenolic compounds, steroids, terpenoid contents possess tremendous anti-anxiety whereas the ethanol root extract (400 mg/kg p.o.) and ethanol leaf extract (400 mg/kg p.o.) produce significant anticonvulsant potential effect compared to the control and standard drug treatment group. This study suggested that the plant M. jalapa is a much more active compound consistent medicinal plant to derive a potent drug against anxiety and convulsion.

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“…The extracts were prepared by adding to intact tissues a volume of ethanol PA (in mL) correspondent to 10 times the organ weight in grams. After 72 h in sealed flasks in the absence of light Samples (Brasil 2010;Shah et al 2004;Shelar et al 2018;Carvalho et al 2019), samples were filtered and the organic fraction dried at < 50 °C (Dai & Mumper 2010;Shelar et al 2018) to obtain the corresponding solid residues. The extracts yield was determined considering the plant material fresh weight and the mass of the dried organic fraction.…”

Section: Ethanolic Extracts Preparationmentioning

confidence: 99%

Phenolic content and antioxidant activity of parts of Passiflora edulis as a function of plant developmental stage

2020

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Passiflora edulis Sims var. flavicarpa O. Deg. (Yellow-passion fruit) is the native plant species most used by juice industries in Brazil while its leaf extracts are widely employed in folk medicine. This study evaluated the phenolic content of leaves, roots, fruit shells and pulp of plants of P. edulis in juvenile, flowering and fruiting stages. The extent of scavenging and/or degradation of reactive nitrogen and oxygen species by plant extracts was also investigated. Leaves were the organs that most accumulated phenolics/flavonoids, regardless of plant developmental stage. Leaf extracts efficiently scavenged DPPH by up to 67 % while root and fruit shell extracts effectively captured up to 80 % O 2-. Maximum activity of catalase (51.6 mmol H 2 O 2 min-1 mg prot-1) and ascorbate peroxidase (2.2 mmol ascorbate min-1 mg prot-1) was recorded in leaf extracts from plants in the fruiting stage. Superoxide dismutase activity reached its highest levels (37.5 U min-1 mg prot-1 , on average) in plant leaves of both juvenile and fruiting plants. Overall, these results suggest that, for therapeutic purposes, parts of P. edulis should be harvested when plants are in the fruiting stage due to the excellent antioxidant properties of their extracts and their accumulation of phenolic compounds.

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Evaluation of anticonvulsant activity of the ethanolic extracts from leaves of Excoecaria agallocha

Cited by 13 publications

References 18 publications

EVALUATION OF THE ANTICONVULSANT ACTIVITY OF THE ETHANOL LEAF EXTRACT OF UVARIA AFZELLI Sc. Elliot (ANNONAECAE) IN MICE

EVALUATION OF THE ANTICONVULSANT ACTIVITY OF THE ETHANOL LEAF EXTRACT OF UVARIA AFZELLI Sc. Elliot (ANNONAECAE) IN MICE

Evaluation of anxiolytic and anticonvulsant potential of Mirabilis jalapa ethanolic extracts on standardized rat models

Phenolic content and antioxidant activity of parts of Passiflora edulis as a function of plant developmental stage

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