Evaluation of antidepressant activity of ondansetron alone and in combination with fluoxetine-an experimental study

Parekar, Sonal M.; Dharmadhikari, Shrikant C.; Jaju, Jugalkishore B.; Pawar, Ganesh; Solunke, Rajvardhan

doi:10.18203/2319-2003.ijbcp20160107

Int J Basic Clin Pharmacol

2016

DOI: 10.18203/2319-2003.ijbcp20160107

|View full text |Cite

Evaluation of antidepressant activity of ondansetron alone and in combination with fluoxetine-an experimental study

Sonal M. Parekar

Shrikant C. Dharmadhikari

Jugalkishore B. Jaju

et al.

Help me understand this report

Search citation statements

Order By: Relevance

Paper Sections

Select...

Citation Types

Supporting

Mentioning

Contrasting

Year Published

2023

Publication Types

Select...

Article1

Relationship

Self Cite0

Independent1

Authors

Journals

Cited by 1 publication

References 4 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

Evaluation of antidepressant effect of palonosetron in Swiss albino mice

Sharma,

Kaushal,

Chawla

2023

National Journal of Pharmacology and Therapeutics

View full text Add to dashboard Cite

INTRODUCTION: Serotonin is one of the most important neurotransmitters influencing mental health and a potential target for pharmacological treatments. 5-hydroxytryptamine (5HT3) receptor antagonists such as ondansetron, mainly used for the management of acute and delayed cancer chemotherapy-induced emesis, have shown antidepressant effects in various studies. Another 5HT3 antagonist, palonosetron approved for delayed cancer chemotherapy-induced emesis, has yet not been studied for antidepressant effects. MATERIALS AND METHODS: Swim despair test was used for the evaluation of antidepressant effect. Swiss Albino mice were used for the test. The animals were randomly divided into 4 groups of 6 each to receive following 4 treatments by intraperitoneal (i.p) route: Group 1 Vehicle, i.e., normal saline (0.1 mL/10 g of body weight i.p.), Group 2: fluoxetine (18 mg/kg i.p), Group 3: palonosetron (0.025 mg/kg i.p), and Group 4: palonosetron (0.05 mg/kg i.p). Efficacy was assessed by the recording of the immobility period after 1 h and 24 h of drug administration. RESULTS: Palonosetron in both doses decreased the immobility time and increased the swimming time depicting antidepressant activity as compared to control. Palonosetron in the dose of 0.05 mg/kg (higher dose) showed a statistically significant (P = 0.000) decrease in the period of immobility at 1 h and 24 h, respectively, as compared to control. Palonosetron in low dose, i.e., 0.025 mg/kg showed decrease in the period of immobility at 1 h and 24 h as compared to the control but the difference was not statistically significant. CONCLUSION: Palonosetron, 5-HT3 receptor antagonist, the drug used for amelioration of chemotherapy-induced nausea and vomiting, has been found to possess antidepressant activity.

show abstract

Evaluation of antidepressant effect of palonosetron in Swiss albino mice

Sharma,

Kaushal,

Chawla

2023

National Journal of Pharmacology and Therapeutics

View full text Add to dashboard Cite

show abstract

scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.

Contact Info

customersupport@researchsolutions.com

10624 S. Eastern Ave., Ste. A-614

Henderson, NV 89052, USA

This site is protected by reCAPTCHA and the Google Privacy Policy and Terms of Service apply.

Blog Terms and Conditions API Terms Privacy Policy Contact Cookie Preferences Do Not Sell or Share My Personal Information

Made with 💙 for researchers

Part of the Research Solutions Family.

Evaluation of antidepressant activity of ondansetron alone and in combination with fluoxetine-an experimental study

Cited by 1 publication

References 4 publications

Evaluation of antidepressant effect of palonosetron in Swiss albino mice

Evaluation of antidepressant effect of palonosetron in Swiss albino mice

Contact Info

Product

Resources

About