Evaluation of Antidiabetic Activities of Casein Hydrolysates by a Bacillus Metalloendopeptidase

Megrous, Sarah; Al-Dalali, Sam; Zhao, Xiao; Chen, Chao; Cao, Ya; Bourouis, Imane; Mekkaoui, Aicha; Yang, Zhijie; Yang, Zhennai

doi:10.1007/s10989-020-10045-3

Cited by 10 publications

(3 citation statements)

References 51 publications

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“…To produce hydrolysates, protein hydrolysis can be carried out by methods such as chemical treatment; microbial fermentation; or enzymatic hydrolysis, by using proteases. Among these techniques, hydrolysis by proteases is the most frequently used to produce bioactive peptides [ 12 ]. Some of the advantages of enzymatic hydrolysis, when compared to chemical hydrolysis or fermentation processes, are: the generation of final products free from toxic compounds and organic solvents; an improved reaction rate; also, this technique is performed under mild temperature and pH conditions; enzymes present high specificity and good stereoselectivity; the reaction normally does not produce secondary products; the use of protease provides an environmentally friendly procedure; enzymatic hydrolysis usually produces higher peptide yields, which also have good quality; enzymes are easy to inactivate; and in general, the process is fairly simple [ 12 , 13 ].…”

Section: Resultsmentioning

confidence: 99%

“…Among these techniques, hydrolysis by proteases is the most frequently used to produce bioactive peptides [ 12 ]. Some of the advantages of enzymatic hydrolysis, when compared to chemical hydrolysis or fermentation processes, are: the generation of final products free from toxic compounds and organic solvents; an improved reaction rate; also, this technique is performed under mild temperature and pH conditions; enzymes present high specificity and good stereoselectivity; the reaction normally does not produce secondary products; the use of protease provides an environmentally friendly procedure; enzymatic hydrolysis usually produces higher peptide yields, which also have good quality; enzymes are easy to inactivate; and in general, the process is fairly simple [ 12 , 13 ]. As disadvantages, several parameters, such as enzyme-substrate ratio, hydrolysis time, pH, and reaction temperature, must be monitored and managed in an optimal range during enzymatic hydrolysis, because these factors may affect diverse properties in the resulting peptides.…”

Section: Resultsmentioning

confidence: 99%

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Critical Review for the Production of Antidiabetic Peptides by a Bibliometric Approach

et al. 2022

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The current bibliometric review evaluated recent papers that researched dietary protein sources to generate antidiabetic bioactive peptides/hydrolysates for the management of diabetes. Scopus and PubMed databases were searched to extract bibliometric data and, after a systematic four-step process was performed to select the articles, 75 papers were included in this review. The countries of origin of the authors who published the most were China (67%); Ireland (59%); and Spain (37%). The journals that published most articles on the subject were Food Chemistry (n = 12); Food & Function (n = 8); and Food Research International (n = 6). The most used keywords were ‘bioactive peptides’ (occurrence 28) and ‘antidiabetic’ (occurrence 10). The most used enzymes were Alcalase® (17%), Trypsin (17%), Pepsin, and Flavourzyme® (15% each). It was found that different sources of protein have been used to generate dipeptidyl peptidase IV (DPP-IV), α-amylase, and α-glucosidase inhibitory peptides. In addition to antidiabetic properties, some articles (n = 30) carried out studies on multifunctional bioactive peptides, and the most cited were reported to have antioxidant and antihypertensive activities (n = 19 and 17, respectively). The present review intended to offer bibliometric data on the most recent research on the production of antidiabetic peptides from dietary proteins to those interested in their obtention to act as hypoglycemic functional ingredients. The studies available in this period, compiled, are not yet enough to point out the best strategies for the production of antidiabetic peptides from food proteins and a more systematic effort in this direction is necessary to allow a future scale-up for the production of these possible functional ingredients.

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Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Critical Review for the Production of Antidiabetic Peptides by a Bibliometric Approach

et al. 2022

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“…The primary peptide production methods include enzymatic hydrolysis, fermentation, and chemical synthesis. However, the products obtained by these methods are complex peptide mixtures that hinder their subsequent applications [5,6]. A wide range of techniques, such as membrane separation [7], resin adsorption [8], salting-out [9], and so on [10][11][12] have been utilized for the isolation of peptides.…”

Section: Introductionmentioning

confidence: 99%

Synthesis of core‐shell material rich in carboxyl groups and its application in the selective adsorption of cationic peptides

Ahmed

Yang

et al. 2023

J of Separation Science

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The ability to extract peptides and proteins from biological samples with excellent reusability, high adsorption capacity, and great selectivity is essential in scientific research and medical applications. Inspired by the advantages of coreshell materials, we fabricated a core-shell material using amino-functionalized silica as the core. Benzene-1,3,5-tricarbaldehyde and 3,5-diaminobenzoic acid were used as model organic ligands to construct a shell coating by alternately reacting the two monomers on the surface of silica microspheres. The resultant material featured an outstanding capability for the adsorption of cationic peptides, most likely owing to its porous structure, a large number of carboxylic functional groups, and low mass-transfer resistance. The maximum saturated adsorption capacity reached 833.3 mg/g and the adsorption process took only 20 min. Under optimized adsorption conditions, the core-shell material was used to selectively adsorb cationic peptides from the tryptic digestive solution of lysozyme and bovine serum albumin, Specifically, the analysis results showed seven cationic peptides in the eluate and twenty anionic peptides in the supernatant, which indicates the efficient trap of most cationic peptides in the digestive solution.

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Response surface methodology and optimization of hydrolysis conditions for the in vitro calcium-chelating and hypoglycemic activities of casein protein hydrolysates prepared using microbial proteases

Megrous,

Zhao,

Al-Dalali

et al. 2024

Food Measure

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Evaluation of Antidiabetic Activities of Casein Hydrolysates by a Bacillus Metalloendopeptidase

Cited by 10 publications

References 51 publications

Critical Review for the Production of Antidiabetic Peptides by a Bibliometric Approach

Critical Review for the Production of Antidiabetic Peptides by a Bibliometric Approach

Synthesis of core‐shell material rich in carboxyl groups and its application in the selective adsorption of cationic peptides

Response surface methodology and optimization of hydrolysis conditions for the in vitro calcium-chelating and hypoglycemic activities of casein protein hydrolysates prepared using microbial proteases

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