Evaluation of antidiabetic activity of bud and flower of Avaram Senna (Cassia auriculata L.) In high fat diet and streptozotocin induced diabetic rats

Nambirajan, Gayathri; Kaleshkumar, Karunanidhi; Garg, Arun; Rajendran, R.; Kandasamy, Ruckmani; Elangovan, Abbirami; Thilagar, Sivasudha

doi:10.1016/j.biopha.2018.10.007

Cited by 57 publications

(19 citation statements)

References 54 publications

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“…Most of the published literature has indicated that various ed- model (Nambirajan et al, 2018;Nanu et al, 2008). Ethanolic extracts of H. rosa-sinensis, chloroform and ethyl acetate extracts of C. gigantea white flower extracts have been identified to reduce blood glucose levels in alloxan-induced diabetic rats (Manivannan and Shopna, 2017).…”

Section: Anticancer Propertiesmentioning

confidence: 99%

Nutraceutical potential of dietary phytochemicals in edible flowers—A review

2021

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Culinary aspects of flowers have been traced back to civilizations of antiquity. They have been a part of the human diet for centuries in various forms as they were considered as medicinal plant foods associated with beneficial health effects (Navarro-González et al., 2015).Previous studies reveal that people from China, the Middle East, Rome, and India used flowers in cooking. Edible flowers were popular in North America and Europe during Queen Victoria's period (Newman & O'Connor, 2013). The usage of flowers as ingredients in a variety of recipes by Chinese can be traced back as far as 3,000 BCE.Edible flowers in ancient China served not only as food ingredients but also as components in herbal treatments (Wongwattanasathien et al., 2010). Early reports indicate that in ancient Rome, the edible flowers of violets and roses were used in purees, omelets and Lavender was used in sauces. In medieval France, the flowers of Calendula (Calendula officinalis) were used as a salad ingredient. In Central Europe, the inflorescences of breaded elder (Sambucus nigra) were often consumed (Acikgoz, 2017).A wide range of flowers are available in different regions of the world but all of them are not suitable for consumption. Some of them are toxic and make the proper identification of edible flowers becoming very important. Generally, edible flowers are defined as nontoxic, innocuous flowers with health benefits consumed in the human diet (Acikgoz, 2017). Utilization of these edible flowers has begun with the consumption of floral parts including the stalk and flower nectar as

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Section: Anticancer Propertiesmentioning

confidence: 99%

Nutraceutical potential of dietary phytochemicals in edible flowers—A review

2021

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“…Post 3 days of diabetes induction, the fasting blood sugar of rats was recorded and the rats with the levels ≥ 300 mg/dl were selected. OGTT was conducted to check glucose tolerance capacity and to confirm the development of diabetes [12]. For OGTT, rats were fasted overnight (18 h) and their baseline glucose level was recorded.…”

Section: Oral Glucose Tolerance Test (Ogtt)mentioning

confidence: 99%

GC-MS Analysis of Chemical Constituents of Hydroalcoholic Leaf Extract of Cissampelos Pareira and Their Anti-Diabetic Activity

Asif¹,

Gilani

Taleuzzaman³

et al. 2021

APRJ

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Aim: The present work deals with the GC-MS-analysis of chemical constituents of hydroalcoholic extract of Cissampelos pareira leaves and thier anti-diabetic activity. Methods: GC-MS analysis of extract was performed using Shimadzu QP-2010 plus with thermal desorption system 20. Acute oral toxicity of extract was done using the Organization of Economic Co-operation and Development (OECD) guideline 423. Diabetes was induced by single dose of streptozotocin 65 mg/kg, i.p. to all the rats except in rats of control group. Following which oral glucose tolerance test was performed and the rats were divided into various experimental groups. Various treatments continued for 21 days. Parameters such as blood glucose level, body weight, liver enzymes, lipid profiles and oxidative markers were checked. Results: GC-MS analysis of the extract identified 25 compounds present in it. Based on acute oral toxicity study three doses of hydroalcoholic extract of Cissampelos pareira leaves viz 100, 200 and 400 mg/kg were selected for evaluation of anti-diabetic activity. The extracts at doses 200 and 400 mg/kg BW were able to reduce blood sugar level, liver enzymes, total cholesterol, total triglyceride, low density lipoprotein and Malondialdehyde; and enhance body weight, high density lipoprotein and Glutathione significantly when compared to rats of negative control group. The effect of extract at dose 400 mg/kg was comparable to standard Glibenclamide. Conclusion: Results conclude that the chemical constituents present in the hydroalcoholic extract of Cissampelos pareira contained some anti-diabetic compounds possessing strong anti-diabetic activity.

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“…It's important to note that the whole procedure of preparation and injection of STZ solution needs to avoid light and the dissolved STZ solution should be used as soon as possible (within 15 min). After STZ administration, model rats continued to eat ad libitum with the high-fat diet in order to attain relatively stable blood glucose level, then 14 days after STZ injection, random blood glucose (RBG) was measured by portable glucometer (Beijing Yicheng biotechnology co. LTD, China) through tail vein, and rats whose RBG were higher than or equal to 16.7 mmol/L were considered as diabetic [19] and were further used in the following experiment.…”

Section: Induction Of Diabetesmentioning

confidence: 99%

Protective effects of calorie restriction on insulin resistance and islets function in STZ-induced type 2 diabetes rats

Zhang

Huang

Sun

et al. 2020

Preprint

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Background Caloric restriction (CR), as the only approved scientific method that can retard aging, has become more and more attractive in the treatment of type 2 diabetes mellitus (T2DM) due to increasingly common high calorie diet and sedentary lifestyle. This study aimed to evaluate its role in T2DM treatment and further explored the potential molecular mechanism.Methods A total of 60 male SD rats were used in this study. Diabetes model was induced by 8 weeks of high-fat diet (HFD) followed by a single dose of streptozotocin injection (30mg/kg). Subsequently, the diabetic rats were fed ab libitum of 28g/day (diabetic control) or 20g/day (30% CR regimen) with HFD for 20 weeks. Meanwhile, normal rats had free standard chow diet served as vehicle control. Body mass, plasma glucose, and lipid profile were monitored. After diabetes-related functional tests being done, rats were sacrificed at 10 and 20 weeks, and glucose uptake in fresh muscle were determined. Liver and pancreas were prepared for histopathology and histochemical evaluations, and western blotting and immunofluorescence were applied to detect alterations in AKT/AS160/GLUT4 signaling. Results 30% CR significantly attenuated hyperglycemia and dyslipidemia, leading to alleviation of glucolipotoxicity, thus protected islets secretion, retarding the exhaustion of islets function. Insulin resistance was also markedly ameliorated, as indicated by notably improved insulin tolerance and HOMA-IR. However, glucose uptake in skeletal muscle was not significantly improved, and the up-regulation of AKT/AS160/GLUT4 signaling in muscle induced by 30% CR attenuated gradually over time. However, the consecutive decrease in AKT/AS160/GLUT4 signaling in white adipose tissue was significantly reversed by 30% CR. Conclusion 30% CR could protect islets function from hyperglycemia and dyslipidemia, and improve insulin resistance with probable mechanism related to the up-regulation of AKT/AS160/GLUT4 signaling.

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Evaluation of antidiabetic activity of bud and flower of Avaram Senna (Cassia auriculata L.) In high fat diet and streptozotocin induced diabetic rats

Cited by 57 publications

References 54 publications

Nutraceutical potential of dietary phytochemicals in edible flowers—A review

Nutraceutical potential of dietary phytochemicals in edible flowers—A review

GC-MS Analysis of Chemical Constituents of Hydroalcoholic Leaf Extract of Cissampelos Pareira and Their Anti-Diabetic Activity

Protective effects of calorie restriction on insulin resistance and islets function in STZ-induced type 2 diabetes rats

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