Evaluation of antidiabetic, antioxidant and vasoprotective effects of Posidonia oceanica extract

Gökçe, Göksel; Haznedaroğlu, Mehmet Zeki

doi:10.1016/j.jep.2007.09.016

Cited by 105 publications

(80 citation statements)

References 50 publications

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“…Insulin defi ciency in diabetic patients leads to increased levels of amino acids in the blood, and it will lead to an increase in transaminase activity (enhanced level of AST and ALT levels); eventually, its result is increase of ketogenesis and gluconeogenesis [12,13]. This paper examined the eff ects of diff erent ratios which concentrate to alfalfa extraction on blood lipids and glucose in rats.…”

Section: Introductionmentioning

confidence: 99%

The effects of aqueous extract of alfalfa on blood glucose and lipids in alloxan-induced diabetic rats

Amraie

Farsani

Sadeghi

et al. 2015

IMAS

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Diabetes is a common metabolic disorder that is specifi ed by hyperglycemia resulting from defects in insulin secretion, insulin action, or both. The use of nonpharmacological treatments (herbal agents) is a new approach in the management of diabetes. The aim of this study was to investigate the eff ect of aqueous extract of alfalfa on blood glucose and serum lipids in alloxan-induced diabetic rats. In this study, 32 female rats (210-250 g) were used which were divided randomly into 4 groups including intact control group, diabetic control group, and 2 diabetic groups which received 250 and 500 mg/kg doses of aqueous extract of alfalfa, respectively. In the diabetic groups, alloxan-monohydrate was injected peritoneally to create diabetic condition. The two last groups orally received aqueous extract of alfalfa for 21 days. At the end of experiment, sugar, cholesterol, triglycerides, high-density and low-density lipoprotein, and aspartate aminotransferase (ALT) and alanine aminotransferase (AST) levels were measured in the samples. Consumption of aqueous alfalfa extract signifi cantly reduced glucose, cholesterol, triglycerides, and low-density lipoprotein (LDL) levels in the diabetic rats but enhanced high-density lipoprotein (HDL) levels. ALT and AST liver enzyme levels were also reduced in blood. Histological examination showed that the aqueous alfalfa extract caused reconstruction of damaged liver and enhanced Langerhans islets' diameter in pancreas. Therefore, all signs of diabetes were improved by oral administration of alfalfa in defi ned dose.

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Section: Introductionmentioning

confidence: 99%

The effects of aqueous extract of alfalfa on blood glucose and lipids in alloxan-induced diabetic rats

Amraie

Farsani

Sadeghi

et al. 2015

IMAS

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“…[6][7][8] Hence, the growing interest to find cheap, renewable and abundant sources of antioxidants has fostered research on marine plants. Many of the biological functions of seagrasses such as antioxidant property, antiviral, anti-diabetic and vaso protective; insecticidal and larvicidal activity have been attributed by the higher phenolic content of seagrass tissue.…”

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confidence: 99%

Evaluation of In-vitro Antioxidant Activity of Seagrasses: Signals for Potential Alternate Source

Danaraj

Subhashini

Raja

et al. 2016

FRA

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Background and Aim: Natural antioxidants have gained unique attention in recent years. Because of the carcinogenicity of synthetic compounds, there is a dearth for antioxidants from natural origin. Currently, seagrasses, the marine plants have gained attention for their secondary metabolites. Hence, the present study aims to examine in vitro antioxidant activity of both leaf and rhizome extracts of six seagrass species and has not yet been investigated. Methods: Crude methanolic extracts of leaf and rhizome obtained, were evaluated for total phenolic contents using Folin-Ciocalteaus method. Antioxidant potential of seagrass extracts were evaluated using total antioxidant activity, DPPH, FRAP, ABTS assay, H 2 O 2 and NO 2 scavenging assay and the phenolic compounds present in potent extracts were profiled by HPLC. Results: Maximum phenolic content and antioxidant activity was exhibited by leaf and rhizome extracts of C. rotundata followed by H. uninervis. Higher DPPH radical scavenging activity was found in leaf (78.84 ± 0.87) and rhizome extracts (75.480 ± 0.97) of C. rotundata and the lowest scavenging activity was found in the leaf and rhizome extracts of H. ovata (12.01 ± 0.63 and 5.769 ± 1.14). Among six species, C. rotundata exhibited higher radical scavenging activity containing the potential phenolic compounds. Conclusion: Present study portrays that leaf and rhizome extracts of C. rotundata acts as a potential source of antioxidant compounds with predominant presence of caffeic acid and ρ-coumaric acid that paves a way for the application of these compounds in both food and pharmaceutical industries as a multipotent antioxidant.

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“…Oxidative stress is one of the contributory factors in the pathogenesis of diabetes. Diabetes, by itself, increases the production of tissue damaging Reactive Oxygen Species (ROS) by glucose auto-oxidation and / or no enzymatic protein glycosylation 2 Complications of diabetes seem to be mediated by oxidative stress. Hyperglycemia is one of the main causes of oxidative stress in type-II diabetes.…”

Section: Discussionmentioning

confidence: 99%

“…In India, it is found in Southern part mainly counting Chennai, and some places of Andhra Pradesh [1]. Traditionally, IR has been used to treat diverse clinical conditions ranging from pain; fever to neurological disorders [2]. IR has been claimed to be useful for inflammation, headache, fever, cough, neuralgia, rheumatism and also in liver and kidney diseases [3].…”

Section: Introductionmentioning

confidence: 99%

“…Another major contributing factor is believed to be the oxidative stress in the pathogenesis of diabetes. Glucose oxidation as well as nonenzymatic protein glycosylation in diabetes itself leads to the increased production of Reactive Oxygen Species (ROS) 2 . Vascular abnormalities such as constriction and dilation of blood vessels were observed in diabetic patients.…”

Section: Introductionmentioning

confidence: 99%

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Screening of Ethanolic Extract of <i>Borassus flabellifer Flowers for its Antidiabetic and Antioxidant Potential

Kavatagimath¹,

Jalalpure²,

Hiremath³

2016

JNR

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Ipomoea reniformis Chaos is claimed in Indian traditional medical practice to be useful in the treatment of epilepsy and neurological disorders. In the present study, pretreatment effect of methanolic extract of Ipomoea reniformis on epilepsy and psychosis was evaluated in rodents using standard procedures. Besides evaluating epileptic and behavioral parameters, neurotransmitters such as Gamma-Amino Butyric Acid (GABA) in epilepsy and in psychosis dopamine, noradrenaline and serotonin contents in the rodent brain were estimated. The extract pretreatment reduced maximal electro shock; Isoniazid (INH) and Pentylenetetrazole (PTZ) induced seizures and also significantly inhibited the attenuation of brain GABA levels by INH and PTZ in mice. These results suggested that the observed beneficial effect in epilepsy may be by enhancing the GABAergic system. The test drug also inhibited the apomorphine induced climbing and stereotyped behavior and showed significantly reduced levels of brain dopamine, noradrenaline and serotonin which may be due to blocking of central dopaminergic, noradrenergic and serotonergic pathways or by enhancing the GABAergic system. The results obtained in present study suggest that the title plant possesses antiepileptic and antipsychotic activities in rodents.

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Evaluation of antidiabetic, antioxidant and vasoprotective effects of Posidonia oceanica extract

Cited by 105 publications

References 50 publications

The effects of aqueous extract of alfalfa on blood glucose and lipids in alloxan-induced diabetic rats

The effects of aqueous extract of alfalfa on blood glucose and lipids in alloxan-induced diabetic rats

Evaluation of In-vitro Antioxidant Activity of Seagrasses: Signals for Potential Alternate Source

Screening of Ethanolic Extract of <i>Borassus flabellifer Flowers for its Antidiabetic and Antioxidant Potential

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