Evaluation of antidiabetic, antioxidant effect and safety profile of gomutra ark in Wistar albino rats

Sachdev, Devender O; Gosavi, Devesh D; Salwe, Kartik J

doi:10.4103/0257-7941.103180

Cited by 16 publications

(8 citation statements)

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“…The wound healing activity of cow urine ark in diabetic Wistar albino rats was evaluated in this study using several models based on previous research, which demonstrated significant anti-diabetic, antimicrobial, and antioxidant effects [ 11 , 12 , 22 ]. Besides, volatile fatty acids present in cow urine ark probably contribute to its antioxidant properties which might reduce oxidative stress in diabetic wounds [ 23 ].…”

Section: Discussionmentioning

confidence: 99%

“…Medicinal properties of cow urine such as bioenhancer, antibiotic, antifungal, and anticancer have been patented under US patent number 6,896,907 and 6,410,059 [ 9 , 10 ]. Several studies had suggested that cow urine has anti-diabetic potential probably due to its antioxidant properties [ 11 , 12 ]. Besides, external application of cow urine on excision wound (EW) has shown to hasten the wound healing [ 13 ].…”

Section: Introductionmentioning

confidence: 99%

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Evaluation of wound healing activity of cow urine ark in diabetic Wistar albino rats

Hirapara¹,

Ghori²,

Anovadiya

et al. 2016

J Intercult Ethnopharmacol

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Aim:To evaluate wound healing activity of cow urine ark in diabetic rats.Materials and Methods:Streptozotocin-induced diabetic Wistar albino rats were randomly divided into six groups (n = 6). Three groups - diabetic control, active control (glibenclamide), and treatment (cow urine ark) were operated for excision wounds (EWs). Rats in these groups received distilled water 1 ml/day, glibenclamide 0.5 mg/kg body weight/day, and cow urine ark 5.5 ml/kg body weight/day orally till complete healing of the EWs. EWs were evaluated for wound contraction on 3rd, 7th, and 11th day and for reepithelization on 11th day. The other three groups were operated for incision wounds (IW) as well as dead space wounds (DW) in the same animal which received the above agents orally for 11 days. IWs were analyzed for wound breaking strength and DWs were analyzed for dry weight, hydroxyproline content, and histology of granulation tissue.Results:EWs showed significantly increased wound closure in the treatment group as compared to the diabetic as well as active control groups at 3rd (P < 0.001) and 11th (P < 0.05) post-wounding day and to the only diabetic control group at 7th (P < 0.01) post-wounding day. IWs showed significant improvement in wound breaking strength in the treatment as compared to diabetic (P < 0.001) and active control (P < 0.01) groups. DWs showed significant increase in hydroxyproline content of granulation tissue in the treatment as compared to diabetic control (P < 0.001) and active control (P < 0.001) groups. Wound breaking strength and hydroxyproline content also significantly increased in the active control group compared to diabetic control (P < 0.001 and P < 0.05, respectively). Granulation tissue dry weight was significantly increased in treatment and active control groups as compared to diabetic control (P < 0.001).Conclusion:Cow urine ark increases granulation tissue formation as well as collagen content. Wound contraction was also significantly improved. The cow urine ark could be potentially effective in promoting healing of diabetic wounds by increasing granulation tissue formation and collagen content, however, further studies are required for its clinical application.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Evaluation of wound healing activity of cow urine ark in diabetic Wistar albino rats

Hirapara¹,

Ghori²,

Anovadiya

et al. 2016

J Intercult Ethnopharmacol

View full text Add to dashboard Cite

show abstract

“…Therefore, the potent ABTS reduction observed in this assay might be due to the antioxidant compounds present in cow urine. Sachdev et al ( 2012 ) revealed that cow urine contains volatile fatty acids such as acetic acid 2 propenyl ester, acetic acid methyl ester, 2,2,3,trichloro propionic acid, butanoic acid-3methyl, propyl ester, 1 H indol-3-acetate, acetic acid phenyl ester and quinoline that may act as an antioxidants. This has been confirmed by the estimation of thiobarbituric acid, ascorbic acid, DPPH radical scavenging activity and ABTS assay.…”

Section: Discussionmentioning

confidence: 99%

Induction of neurotoxicity by organophosphate pesticide chlorpyrifos and modulating role of cow urine

Sharma

Chadha

2016

SpringerPlus

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IntroductionOrganophosphate pesticides are among the most widely used synthetic chemicals for controlling a wide variety of pests and for domestic purposes. Among these chlorpyrifos (CPF) is the most extensively used pesticide throughout the world, including India.ObjectiveThe present study was undertaken to examine the neurotoxicity induced by CPF and modulatory effect of cow urine as a natural antioxidant alternative to reduce the neurotoxic effects of CPF.DesignFor this purpose LD50 was determined and one fourth of LD50 was selected (38 mg/kg body weight (b.wt)) for treatment of rats. The antioxidant level of cow urine was determined by ABTS assay.ResultsExposure to pesticides resulted in significant reduction in the acetylcholinestrase (AChE) activity (P ≤ 0.01). However, groups pretreated with cow urine had improved levels of AChE activity as compared to CPF treated groups.ConclusionThus, the present findings clearly show that oral CPF has the propensity to cause significant neurotoxicity in rat brains while cow urine treatment alleviates CPF induced toxicity to a greater extent. In addition, AChE can be used as a potential biomarker of toxicity associated with pesticide exposure.

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“…The phenolic compounds and flavonoid constituents in lupin seed extracts have important antioxidant activity [ 51 , 52 ]. Lupin protein hydrolysates present anti-inflammatory properties [ 53 ]. The antifungal and antibacterial activities have been demonstrated in different studies that report an inhibitory effect toward various bacterial and fungal pathogens [ 54 , 55 ].…”

Section: Lupin a Unique Legume In So Many Waysmentioning

confidence: 99%

Lupin, a Unique Legume That Is Nodulated by Multiple Microsymbionts: The Role of Horizontal Gene Transfer

Msaddak

Mars

Quiñones

et al. 2023

IJMS

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Lupin is a high-protein legume crop that grows in a wide range of edaphoclimatic conditions where other crops are not viable. Its unique seed nutrient profile can promote health benefits, and it has been proposed as a phytoremediation plant. Most rhizobia nodulating Lupinus species belong to the genus Bradyrhizobium, comprising strains that are phylogenetically related to B. cytisi, B. hipponenese, B. rifense, B. iriomotense/B. stylosanthis, B. diazoefficiens, B. japonicum, B. canariense/B. lupini, and B. retamae/B. valentinum. Lupins are also nodulated by fast-growing bacteria within the genera Microvirga, Ochrobactrum, Devosia, Phyllobacterium, Agrobacterium, Rhizobium, and Neorhizobium. Phylogenetic analyses of the nod and nif genes, involved in microbial colonization and symbiotic nitrogen fixation, respectively, suggest that fast-growing lupin-nodulating bacteria have acquired their symbiotic genes from rhizobial genera other than Bradyrhizobium. Horizontal transfer represents a key mechanism allowing lupin to form symbioses with bacteria that were previously considered as non-symbiotic or unable to nodulate lupin, which might favor lupin’s adaptation to specific habitats. The characterization of yet-unstudied Lupinus species, including microsymbiont whole genome analyses, will most likely expand and modify the current lupin microsymbiont taxonomy, and provide additional knowledge that might help to further increase lupin’s adaptability to marginal soils and climates.

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Evaluation of antidiabetic, antioxidant effect and safety profile of gomutra ark in Wistar albino rats

Cited by 16 publications

References 2 publications

Evaluation of wound healing activity of cow urine ark in diabetic Wistar albino rats

Evaluation of wound healing activity of cow urine ark in diabetic Wistar albino rats

Induction of neurotoxicity by organophosphate pesticide chlorpyrifos and modulating role of cow urine

Lupin, a Unique Legume That Is Nodulated by Multiple Microsymbionts: The Role of Horizontal Gene Transfer

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