Evaluation of antidiabetic potential of steroidal alkaloid of Sarcococca saligna

Jan, Naeem Ullah; Ali, Amjad; Ahmad, Bashir; Iqbal, Naveed; Adhikari, Achyut; Inayat-Ur-Rehman,; Ali, Abid; Ali, Safdar; Jahan, Azra; Ali, Hamid; Ali, Ijaz; Ullah, Atta; Musharraf, Syed Ghulam

doi:10.1016/j.biopha.2018.01.008

Cited by 27 publications

(10 citation statements)

References 14 publications

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“…In 2017, around 425 million adults in the age group of (20-79 years) reported to affect by diabetes and estimated to grow to 629 million by 2045 (Saeedi et al 2019). Nowadays, combined therapy with several oral hypoglycemic agents is used to manage diabetes, but therapies possess numerous side effects (Choudhary et al 2020;El Deeb et al 2019;Ullah Jan et al 2018). However, effective and safe treatment in curing diabetes is yet to be achieved.…”

Section: Introductionmentioning

confidence: 99%

RETRACTED ARTICLE: Ameliorative potential of Operculina turpethum against streptozotocin-induced diabetes in rats: biochemical and histopathological studies

et al. 2021

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The study aimed to investigate the acute toxicity, antidiabetic potential (in-vitro and in-vivo) of the Operculina turpethum (L.) Silva Manso at fraction level. The plant was fractionated into different fractions, i.e., flavonoid fraction (OTFF), tannin fraction (OTTF), saponin fraction (OTSF). In-vitro alpha-amylase inhibition assay revealed that OTFF was found to be more potent than standard Acarbose. The plant fractions were evaluated by MTT assay at different concentrations ranging from 100 to 1000 µg/ml. All the fractions were further evaluated for their safety profile, and the biochemical, hematology and histopathology result exhibits that the OTFF fraction produces mild toxicity at organ level at a concentration of 2000 mg/ kg in albino mice. The in-vivo antidiabetic study was carried out on Sprague-Dawley rats using high-fat diet (HFD) feeding streptozotocin (STZ) diabetic model, and the biochemical, histopathology research findings represent that OTFF at a concentration of 500 mg/kg, p.o. was found to be highly significant among all the fractions and found to be more potent than the standard Acarbose. LC-MS characterization of the bioactive fraction OTFF showed the presence of rutin with m/z 610.52 in 50.50% and Apigenin 7-O-6'' acetyl-glucoside with m/z 475.42 in 24.10%; from molecular docking study, it is predicted that the fraction primarily acts as an alpha-amylase inhibitor and PPAR gamma agonist. In conclusion, the plant's OTFF fraction acts as a potential therapeutic agent for Type II diabetes mellitus.

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Section: Introductionmentioning

confidence: 99%

RETRACTED ARTICLE: Ameliorative potential of Operculina turpethum against streptozotocin-induced diabetes in rats: biochemical and histopathological studies

et al. 2021

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“…In general, the moisture contents of the dried peels and seeds of Acco, Big Full, and Wonderful cultivars were greater than those reported in the literature for peels and seeds from different cultivars, after being subjected to different time-temperature drying conditions. Güzel and Akpinar [40] and Ullah et al [41] reported a moisture content of 10.3% and 4.0%, respectively, for dried peels (drying process: 48 h at 60 °C and 50 °C, respectively). Jalal et al [42] reported a moisture content of 12.5% for peels and of 5.8% for seeds, dried at 60 °C for 12 and 6 h, respectively.…”

Section: Pomegranate Peel and Seed Characterization Andmentioning

confidence: 99%

Pomegranate Peels and Seeds as a Source of Phenolic Compounds: Effect of Cultivar, By-Product, and Extraction Solvent

Campos

Seixas

Henriques

et al. 2022

International Journal of Food Science

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The nutraceutical properties of Punica granatum L. are not restricted to the edible portion of the fruit but also to the peels and seeds, flowers, leaves, and tree bark. The recovery and valorization of the peel and seeds (ca. 50% of the whole fruit), besides the positive environmental impact, can be viewed as a source of natural bioactive compounds. Thus, the bioactive properties of extracts of pomegranate peel and seeds from Acco and Wonderful known cultivars, as well as of the novel Big Full cultivar, were evaluated. The dried and ground pomegranate by-products were submitted to a conventional solid/liquid extraction with ethanol/water mixtures (0%, 25%, 50%, and 75% of EtOH, v/v). The obtained extracts were characterized in terms of total phenolic compounds (TPC), total flavonoids (TF), and antioxidant activity (AA), determined by the DPPH radical scavenging activity and expressed as IC50 (half maximum inhibitory concentration). With the exception of the Acco cultivar, the extraction yield (EY) was higher for peels, whose extracts showed higher TPC, TF, and IC50 (lower AA). The extracts obtained from the by-products of the Big Full cultivar had a statistically higher overall bioactive potential (TPC: 0.36 mg GAE/mg extract; TF: 0.031 mg CATE/mg extract; IC50: 0.51 mg/mL) compared to the other two studied cultivars. Furthermore, the EY was enhanced by solvents richer in ethanol (50-75%), allowing obtaining extracts richer in TPC and TF with higher AA. Finally, it was shown that EY combined with bioactive data allowed a satisfactory principal component unsupervised differentiation of the pomegranate extracts according to the type of by-product used.

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“…Flavonoid memiliki mekanisme kerja dalam menurunkan kadar gula darah dengan menghambat penyerapan karbohidrat di usus, meningkatkan uptake glukosa, meningkatkan sekresi insulin, serta melindungi sel pancreas dari kerusakan (14). Alkaloid menghambat penyerapan glukosa dalam usus sehingga memiliki efek dalam menurunkan kadar gula darah (15). Menurut penelitian (16)…”

Section: Pembahasanunclassified

UJI ANTIHIPERGLIKEMIA REBUSAN DAUN SALAM (Syzygium polyanthum) PADA MENCIT YANG DIINDUKSI GLUKOSA

Kartikaningrum¹

2022

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Diabetes mellitus menjadi masalah kesehatan masyarakat, tidak hanya di Indonesia tetapi juga di dunia. Selain antidiabetika oral, pasien diabetes mellitus tipe 2 ini juga banyak menggunakan obat herbal sebagai obat komplementer alternatif penyembuhan. Flavonoid yang terkandung di dalam daun salam merupakan salah satu golongan senyawa yang dapat menurunkan kadar glukosa darah.Penelitian ini dilakukan untuk mengetahui pengaruh air rebusan daun salam (Syzygium polyanthum) terhadap penurunan kadar glukosa darah pada mencit (Mus musculus L.) yang hiperglikemia. Hewan percobaan dibagi menjadi empat kelompok. Kelompok 1 adalah kelompok kontrol normal, yaitu hewan yang tidak diberi perlakuan apapun, kelompok 2 adalah kelompok kontrol negatif, yaitu hewan yang diberi induksi glukosa namun tidak diberi air rebusan daun salam, kelompok 3 adalah kelompok hewan hasil induksi glukosa dan diberi air rebusan daun salam 0,2 ml/20 gBB, kelompok 4 adalah kelompok hewan hasil induksi glukosa dan diberi air rebusan daun salam 0,4 ml/20 gBB. Kadar glukosa darah mencit setelah perlakuan selama 7 hari kelompok 1 97,8 mg/dl, kelompok 2 265,4 mg/dl, kelompok 3 204,5 mgdl, dan kelompok 4 164,7 mg/dl. Dari hasil penelitian dapat disimpulkan bahwa pemberian air rebusan daun salam (Syzygium polyanthum) selama 7 hari dapat menurunkan kadar glukosa darah mencit meskipun penurunannya tidak sebanding dengan kadar normal.

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Evaluation of antidiabetic potential of steroidal alkaloid of Sarcococca saligna

Cited by 27 publications

References 14 publications

RETRACTED ARTICLE: Ameliorative potential of Operculina turpethum against streptozotocin-induced diabetes in rats: biochemical and histopathological studies

RETRACTED ARTICLE: Ameliorative potential of Operculina turpethum against streptozotocin-induced diabetes in rats: biochemical and histopathological studies

Pomegranate Peels and Seeds as a Source of Phenolic Compounds: Effect of Cultivar, By-Product, and Extraction Solvent

UJI ANTIHIPERGLIKEMIA REBUSAN DAUN SALAM (Syzygium polyanthum) PADA MENCIT YANG DIINDUKSI GLUKOSA

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