Evaluation of antiepileptic effect of S-adenosyl methionine and its role in memory impairment in pentylenetetrazole-induced kindling model in rats

Dhediya, Rajnish; Joshi, Shirish; Gajbhiye, Snehalata; Jalgaonkar, Sharmila; Biswas, Mansij

doi:10.1016/j.yebeh.2016.05.024

Cited by 12 publications

(5 citation statements)

References 25 publications

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“…The retrieval memory impairment accompanied by PTZ chronic treatment was previously demonstrated in numerous previous studies in elevated plus maze (EPM) paradigm [2,33,[41][42][43] and several other behavioral tests, e.g., MWM paradigm [44][45][46]. In the current study, the procognitive effect of H3R antagonist E177 (5 and 10 mg/kg, i.p.)…”

Section: Effects Of E177 On Mmemory Deficits In Inhibitory Avoidance supporting

confidence: 57%

“…Epilepsy is a prevalent and severe chronic neurological disorder, with elevated incidence of neurological disability and mortality worldwide [1]. Epilepsy characterized by repetitive unprovoked Molecules 2020, 25, 1575; doi:10.3390/molecules25071575 www.mdpi.com/journal/molecules seizures leading to devastating neurological results on the patients [2], which requires long time therapy with antiepileptic drugs (AEDs), but presently available AEDs are not capable to provide sufficient seizures control in almost one-third of the patients and also do not stop the underlying epileptogenic alterations [3]. Moreover, the consistent use of one or more AEDs will augment the epilepsy-associated comorbidities such as cognitive impairment [4].…”

Section: Introductionmentioning

confidence: 99%

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Antagonism of Histamine H3 receptors Alleviates Pentylenetetrazole-Induced Kindling and Associated Memory Deficits by Mitigating Oxidative Stress, Central Neurotransmitters, and c-Fos Protein Expression in Rats

et al. 2020

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Histamine H3 receptors (H3Rs) are involved in several neuropsychiatric diseases including epilepsy. Therefore, the effects of H3R antagonist E177 (5 and 10 mg/kg, intraperitoneal (i.p.)) were evaluated on the course of kindling development, kindling-induced memory deficit, oxidative stress levels (glutathione (GSH), malondialdehyde (MDA), catalase (CAT), and superoxide dismutase (SOD)), various brain neurotransmitters (histamine (HA), acetylcholine (ACh), γ-aminobutyric acid (GABA)), and glutamate (GLU), acetylcholine esterase (AChE) activity, and c-Fos protein expression in pentylenetetrazole (PTZ, 40 mg/kg) kindled rats. E177 (5 and 10 mg/kg, i.p.) significantly decreased seizure score, increased step-through latency (STL) time in inhibitory avoidance paradigm, and decreased transfer latency time (TLT) in elevated plus maze (all P < 0.05). Moreover, E177 mitigated oxidative stress by significantly increasing GSH, CAT, and SOD, and decreasing the abnormal level of MDA (all P < 0.05). Furthermore, E177 attenuated elevated levels of hippocampal AChE, GLU, and c-Fos protein expression, whereas the decreased hippocampal levels of HA and ACh were modulated in PTZ-kindled animals (all P < 0.05). The findings suggest the potential of H3R antagonist E177 as adjuvant to antiepileptic drugs with an added advantage of preventing cognitive impairment, highlighting the H3Rs as a potential target for the therapeutic management of epilepsy with accompanied memory deficits.

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Section: Effects Of E177 On Mmemory Deficits In Inhibitory Avoidance supporting

confidence: 57%

Section: Introductionmentioning

confidence: 99%

Antagonism of Histamine H3 receptors Alleviates Pentylenetetrazole-Induced Kindling and Associated Memory Deficits by Mitigating Oxidative Stress, Central Neurotransmitters, and c-Fos Protein Expression in Rats

et al. 2020

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“…Indeed, SAMe is an effective antidepressant drug [64,69] as it is well tolerated and may have a relatively faster onset of action than conventional antidepressants [64]. In addition, an antiepileptic and memoryenhancing effect of SAMe administration in a PTZ-induced kindling model of epilepsy has also been demonstrated [70]. In our studies, we used L-MET at a dose (50 mg/kg) that increases the brain level of SAMe.…”

Section: Discussionmentioning

confidence: 99%

Antidepressant and Anxiolytic Effects of L-Methionine in the WAG/Rij Rat Model of Depression Comorbid with Absence Epilepsy

Sarkisova

Gabova

Fedosova

et al. 2023

IJMS

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Depression is a severe and widespread psychiatric disease that often accompanies epilepsy. Antidepressant treatment of depression comorbid with epilepsy is a major concern due to the risk of seizure aggravation. SAMe, a universal methyl donor for DNA methylation and the synthesis of brain monoamines, is known to have high antidepressant activity. This study aimed to find out whether L-methionine (L-MET), a precursor of SAMe, can have antidepressant and/or anxiolytic effects in the WAG/Rij rat model of depression comorbid with absence epilepsy. The results indicate that L-MET reduces the level of anxiety and depression in WAG/Rij rats and suppresses associated epileptic seizures, in contrast to conventional antidepressant imipramine, which aggravates absence seizures. The antidepressant effect of L-MET was comparable with that of the conventional antidepressants imipramine and fluoxetine. However, the antidepressant profile of L-MET was more similar to imipramine than to fluoxetine. Taken together, our findings suggest that L-MET could serve as a promising new antidepressant drug with anxiolytic properties for the treatment of depression comorbid with absence epilepsy. Increases in the level of monoamines and their metabolites—DA, DOPAC, HVA, NA, and MHPG—in several brain structures, is suggested to be a neurochemical mechanism of the beneficial phenotypic effect of L-MET.

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“…Therefore SAM can be regarded as a treatment option for depressive disorders that increase monoamines: low levels of SAM, elevated homocysteine, and low 5-HT, DA, and NA are usually found in depressive patients ( Bottiglieri et al, 2000 ). Moreover, it has been also demonstrated antiepileptic and memory-enhancing effects of SAM administration in a PTZ-induced kindling model of epilepsy ( Dhediya et al, 2016 ).…”

Section: Epigenetic Treatments Of Absence Epilepsy and Comorbiditiesmentioning

confidence: 99%

Evaluation of antiepileptic effect of S-adenosyl methionine and its role in memory impairment in pentylenetetrazole-induced kindling model in rats

Cited by 12 publications

References 25 publications

Antagonism of Histamine H3 receptors Alleviates Pentylenetetrazole-Induced Kindling and Associated Memory Deficits by Mitigating Oxidative Stress, Central Neurotransmitters, and c-Fos Protein Expression in Rats

Antagonism of Histamine H3 receptors Alleviates Pentylenetetrazole-Induced Kindling and Associated Memory Deficits by Mitigating Oxidative Stress, Central Neurotransmitters, and c-Fos Protein Expression in Rats

Antidepressant and Anxiolytic Effects of L-Methionine in the WAG/Rij Rat Model of Depression Comorbid with Absence Epilepsy

The impact of early-life environment on absence epilepsy and neuropsychiatric comorbidities

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