Evaluation of antihepatotoxic potential of Solanum xanthocarpum fruit extract against antitubercular drugs induced hepatopathy in experimental rodents

Hussain, Talib; Gupta, Ramesh K.; Sweety, K; Khan, Mohd Sajid; Hussain, Sarfaraj; Arif,; Hussain, Arshad; Faiyazuddin, Md.; Rao, Chandana Venkateswara

doi:10.1016/s2221-1691(12)60075-6

Cited by 65 publications

(38 citation statements)

References 36 publications

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“…Our study revealed that MECA administration at a higher dose level significantly increased hepatic GSH and SOD levels that were depleted in the antitubercular control group. This may be due to stimulation of de novo synthesis of the antioxidant enzymes, which may be because of capability of MECA to cause upregulation of transcriptional factors (Hussain et al, 2012). Thus, MECA indirectly prevents the formation of toxic metabolites of INH by stimulating the synthesis of hepatic antioxidant enzymes.…”

Section: Discussionmentioning

confidence: 99%

Hepatoprotective potential ofCassia auriculataroots on ethanol and antitubercular drug-induced hepatotoxicity in experimental models

Jaydeokar

Bandawane

Bibave

et al. 2014

Pharmaceutical Biology

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Context: Tarvada [Cassia auriculata Linn. (Caesalpiniaceae)] is used against liver ailments in Indian folk medicine, but there is a lack of scientific evidence for this traditional claim. Objective: The present study investigated the protective effect of methanol extract of tarvada (MECA) roots on ethanol and antitubercular drug induced hepatotoxicity in rats. Materials and methods: In the therapeutic model, ethanol (40%, 4 g/kg b.w., p.o.) was administered to rats for 21 days and the intoxicated rats were treated with MECA (300 and 600 mg/kg, b.w.) and silymarin (100 mg/kg, b.w.) for next 7 days. In the prophylactic model, MECA and silymarin were administered simultaneously along with a combination of isoniazid (27 mg/kg, b.w.), rifampicin (54 mg/kg, b.w.) and pyrazinamide (135 mg/kg, b.w.) for 30 days. After the study duration, serum levels of AST, ALT, ALP, total bilirubin, total cholesterol, total protein, albumin were estimated along with hepatic catalase (CAT), reduced glutathione (GSH), superoxide dismutase (SOD), malondialdehyde (MDA) and liver histopathology in each group. Results: Administration of tarvada root extract significantly (p50.01 and p50.05) lowered the elevated levels of serum AST, ALT, ALP, total bilirubin, total cholesterol, total protein and restored the abnormal levels of enzymatic antioxidants and MDA in liver due to toxicant administration in a dose-dependent manner. These results were confirmed by histopathological analysis. Discussion and conclusion: Results suggest that tarvada root extract possess potent hepatoprotective activity against ethanol and antitubercular drug-induced hepatotoxicity in rats, which could be due to an inhibition of hepatic metabolizing enzymes and antioxidant activity.

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Section: Discussionmentioning

confidence: 99%

Hepatoprotective potential ofCassia auriculataroots on ethanol and antitubercular drug-induced hepatotoxicity in experimental models

Jaydeokar

Bandawane

Bibave

et al. 2014

Pharmaceutical Biology

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“…The animals were assigned to different groups according to a block permuted randomization plan. Group [17] . On completion of the experimental period the blood was collected, the animals were sacrificed and liver samples were collected.…”

Section: Anti Tubercular Drugs Induced Hepatotoxicitymentioning

confidence: 99%

Anti-hepatotoxic and antioxidant influence of Ipomoea carnea against anti-tubercular drugs induced acute hepatopathy in experimental rodents

2013

JCLM

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“…Therefore, they have been widely used in treating obesity [5,8,13]. Solanum xanthocarpum fruits are known for several traditional uses as medicine, like anthelmintic, laxative, antipyretic, anti-asthmatic, anti-inflammatory activity and enlargement of liver [14][15][16].…”

Section: Introductionmentioning

confidence: 99%

Evaluation of Anti-Obesity Activity of Solasodine in High Fat Diet-Induced Obesity in Rat

Khaserao

Somani

2017

Int J Pharm Pharm Sci

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Objective: This study was planned to study the anti-obesity activities of solasodine on high fat (HF) diet-induced obese rats.Methods: Wistar rats were divided into six groups. Control group (Group 1) received normal diet and 0.5 % CMC (5 ml/kg). HF control group (Group 2) received HF diet. Group 3 received orlistat (25 mg/kg body weight per oral). Group 4, 5 and 6 received 25, 50 and 100 mg/kg body weight solasodine respectively. Treatment was given for 6 w to the respective group along with HF diet. Body weight, food intake and abdomen circumference was measured every week for 6 w. On day 42, the serum biochemical parameters like blood glucose and insulin, serum leptin, total cholesterol and triglyceride were evaluated. Animals were sacrificed with overdose of diethyl ether. The liver and retroperitoneal adipose tissues were removed and weighed immediately. Results:Treatment with solasodine at dose of 50 mg/kg and 100 mg/kg significantly (p<0.001) reduced body weight, abdomen circumference and retroperitoneal adipose tissue weight as compared to the HF diet control group. Solasodine also significantly reduced serum total cholesterol, triglyceride and glucose level as compared to HF diet control group (***p<0.001, **p<0.01, *p<0.05 when compared with normal control. ###p<0.001, #p<0.05 when compared with high fat control). In addition, it also inhibited the induction of fatty liver with accumulation of hepatic triglyceride. Conclusion:Solasodine exhibited anti-obesity effect by showing a reduction in body weight, abdomen circumference, total cholesterol level, triglyceride level and glucose level in high-fat diet fed rats.

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Evaluation of antihepatotoxic potential of Solanum xanthocarpum fruit extract against antitubercular drugs induced hepatopathy in experimental rodents

Abstract: The results of this study strongly indicate the protective effect of S. xanthocarpum against liver injury which may be attributed to its hepatoprotective activity, and thereby scientifically support its traditional use.

Cited by 65 publications

References 36 publications

Hepatoprotective potential ofCassia auriculataroots on ethanol and antitubercular drug-induced hepatotoxicity in experimental models

Hepatoprotective potential ofCassia auriculataroots on ethanol and antitubercular drug-induced hepatotoxicity in experimental models

Anti-hepatotoxic and antioxidant influence of Ipomoea carnea against anti-tubercular drugs induced acute hepatopathy in experimental rodents

Evaluation of Anti-Obesity Activity of Solasodine in High Fat Diet-Induced Obesity in Rat

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