Evaluation of Antiinflammatory Activity of Ethanol Extract of &lt;i&gt;Nelumbo nucifera&lt;/i&gt; Fruit

Rajput, Muhammad Ali; Zehra, Tabassum; Ali, Fizzah; Kumar, Gunesh

doi:10.4274/tjps.galenos.2019.47108

Cited by 6 publications

(6 citation statements)

References 18 publications

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“…Bark extract NT Bark extract protected the myocardium inflammation as a result of doxorubicin (Dox)-induced oxidative stress in Wistar rats [326]. Flowers extract suppressed TNF-α secretion in LPS-stimulated macrophages [327]; fruits extract-reduced carrageenin-induced paw oedema in rats [328]; also upregulated anti-inflammatory cytokines (IL-10 and 12), and downregulated pro-inflammatory cytokines (IL-6, IL-1β, TNF-α, and IFN-γ) [329]; rhizome extract reduced carrageenin-and serotonin-induced paw oedema in male albino Wistar rats [225]; leaves extract reduces the expression and productions of IL-1β, IL-6, TNF-α, PGE 2 , and NO; also reduced NF-κB activity by inhibiting NF-κB phosphorylation [330]. Pure compounds reduced LPS and LPS + a pan-caspase inhibitor (Z-VAD)-induced secretion of nitrite, inflammatory cytokines, and expression of iNOS and COX-2; oral administration of Neferine reduced inflammation in DSS-induced colitis model [281,282]; it also reduced IL-6 and TNF-α production in LPS-activated RAW 264.7 cells, and activated peroxisome proliferator-activated receptor (PPARα and PPARγ) [331]; quercetin 3-O-β-D-glucuronid reduced NO release in LPS-treated RAW 264.7 cells [332]; quercetin and Cianidanol inhibited JNK-and NF-κB-regulated pathways [333]; Betulinic acid reduced carrageenin and serotonin-induced rat paw oedema [225].…”

Section: Nauclea Orientalismentioning

confidence: 99%

Indigenous Uses, Phytochemical Analysis, and Anti-Inflammatory Properties of Australian Tropical Medicinal Plants

Yeshi

Turpin

Jamtsho³

et al. 2022

Molecules

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Australian tropical plants have been a rich source of food (bush food) and medicine to the first Australians (Aboriginal people), who are believed to have lived for more than 50,000 years. Plants such as spreading sneezeweed (Centipeda minima), goat’s foot (Ipomoea pes-caprae), and hop bush (Dodonaea viscosa and D. polyandra) are a few popular Aboriginal medicinal plants. Thus far, more than 900 medicinal plants have been recorded in the tropical region alone, and many of them are associated with diverse ethnomedicinal uses that belong to the traditional owners of Aboriginal people. In our effort to find anti-inflammatory lead compounds in collaboration with Aboriginal communities from their medicinal plants, we reviewed 78 medicinal plants used against various inflammation and inflammatory-related conditions by Aboriginal people. Out of those 78 species, we have included only 45 species whose crude extracts or isolated pure compounds showed anti-inflammatory properties. Upon investigating compounds isolated from 40 species (for five species, only crude extracts were studied), 83 compounds were associated with various anti-inflammatory properties. Alphitolic acid, Betulinic acid, Malabaric acid, and Hispidulin reduced proinflammatory cytokines and cyclooxygenase enzymes (COX-1 and 2) with IC50 values ranging from 11.5 to 46.9 uM. Other promising anti-inflammatory compounds are Brevilin A (from Centipeda minima), Eupalestin, and 5′-methoxy nobiletin (from Ageratum conyzoides), Calophyllolide (from Calophyllum inophyllum), and Brusatol (from Brucea javanica). D. polyandra is one example of an Aboriginal medicinal plant from which a novel anti-inflammatory benzoyl ester clerodane diterpenoid compound was obtained (compound name not disclosed), and it is in the development of topical medicines for inflammatory skin diseases. Medicinal plants in the tropics and those associated with indigenous knowledge of Aboriginal people could be a potential alternative source of novel anti-inflammatory therapeutics.

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Section: Nauclea Orientalismentioning

confidence: 99%

Indigenous Uses, Phytochemical Analysis, and Anti-Inflammatory Properties of Australian Tropical Medicinal Plants

Yeshi

Turpin

Jamtsho³

et al. 2022

Molecules

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“…Phytochemical screening of the TP crude extract showed the presence of flavonoids, phenolics, and alkaloid compounds. These bioactive compounds make TP a potent candidate for potential pharmaceutical use to promote human health [ 8 , 23 , 24 ]. Several studies have demonstrated that flavonoids have anti-inflammatory properties in acute and chronic inflammation [ 8 , 25 ].…”

Section: Discussionmentioning

confidence: 99%

“…High doses (200 mg/kg) of TP for 28 days have been reported to exhibit toxic effects on different organs, such as the kidney and liver [ 24 ]. The effects of the crude extract of TP cannot be attributed to a single phytochemical moiety [ 8 , 23 ]. Many studies attributed anti-inflammatory properties of TP to the presence of flavonoids [ 15 , 26 ].…”

Section: Discussionmentioning

confidence: 99%

“…This method is accepted for testing the biphasic events of acute inflammation [ 25 ]. The first phase (1–3 h) is mediated by the release of histamine and serotonin, the increase of vascular permeability and the formation of edema [ 23 ]. The second phase (3–5 h) is mediated by the release of pro-inflammatory cytokines and prostaglandins [ 8 ].…”

Section: Discussionmentioning

confidence: 99%

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Alcoholic extracts of Teucrium polium exhibit remarkable anti-inflammatory activity: In vivo study

2023

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Teucrium polium (germander, Lamiaceae) is a local plant in Qatar that has been used in folk medicine to treat numerous illnesses. It is known for its antioxidant, analgesic, anticancer, and antibacterial activities. This study aimed to evaluate the anti-inflammatory activity of Teucrium polium (TP) extract by α-carrageen-induced paw edema in adult Sprague Dawley rats. The animals were randomly grouped into control, acute inflammation, and plant extract groups. Acute inflammation was induced by a sub-plantar injection of 100 µL of 1% α-carrageenan into the rat’s right hind paw. Three different doses of the ethanolic extract of TP were tested at different time periods (1, 3, and 5 hours). All doses of the TP ethanolic extract showed significant inhibition of α-carrageenan-induced rat paw edema in a dose-dependent manner in both early and late phases of edema formation. The size of the α-carrageen induced paw edema was significantly reduced one, three, and five hours after TP extract injection compared to the acute inflammation group. This inhibition was accompanied by high expression of interleukin 10 (IL-10) and low expression of monocyte chemoattractant protein 1 (MCP-1), IL-1β and tumor necrosis factor alpha (TNF-α). The results indicated that the ethanolic extracts of TP possess significant anti-inflammatory and potential pharmaceutical properties.

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“…The right hind paw was not treated and taken as a comparison. The paw volume was measured at 0, 30 minutes, 1, 2, 3, 4, and 5 hours following carrageenan injection using a plethysmometer [20][21][22] . The formula for calculating the percentage of inhibition was presented in equation [1], in which A was the mean paw volume for the test group and B was the mean paw volume for the control group.…”

Section: Anti-inflammatory Activity By Carrageenan Inductionmentioning

confidence: 99%

Anti-inflammatory Activity of Water Extract of Luvunga sarmentosa (BI.) Kurz Stem in the Animal Models

et al. 2022

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The study was aimed to determine the anti-inflammatory activity of water extract of the Luvunga sarmentosa stem in an animal model. Twenty-five Wistar rats were divided into five groups (n=5). Group 1 was administered 0.9% normal saline (negative control), group 2 was administered 150 mg/kg diclofenac sodium (positive control), and groups 3 to 5 were administered 50, 300, and 550 mg/kg BW of L. sarmentosa extract, respectively. Carrageenan was injected subcutaneously into each rat's subplantar region of the left hind paw. The paw volume was measured using a plethysmometer. The results showed that the water extract of L. sarmentosa stem (doses of 50, 300, and 550 mg/kg BW) significantly reduced the paw edema volume from the 4th to 5th hour compared to the negative control. The percent inhibition of edema at the 5th hour is 47.45; 46.95; 50.39%. The first phase of the edema (1st and 2nd hour) was not affected by the extract. Meanwhile, diclofenac sodium decreased paw edema volume from the 1st to 5th hour with a percent inhibition of 95.90% at the 5th hour. The histopathology result is relevant to the percentage inhibition of edema. Treatment with L. sarmentosa extract showed slight improvement, destruction of epidermal tissue, hyperkeratotic skin, and subepidermal edema. Meanwhile, positive control showed no inflammatory signs with normal keratin, subepidermal, and subcutaneous layers. The water extract of L. sarmentosa stem has anti-inflammatory activity. This extract effectively reduces the paw edema volume in the late phase with decreased neutrophil infiltration.

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Evaluation of Antiinflammatory Activity of Ethanol Extract of <i>Nelumbo nucifera</i> Fruit

Cited by 6 publications

References 18 publications

Indigenous Uses, Phytochemical Analysis, and Anti-Inflammatory Properties of Australian Tropical Medicinal Plants

Indigenous Uses, Phytochemical Analysis, and Anti-Inflammatory Properties of Australian Tropical Medicinal Plants

Alcoholic extracts of Teucrium polium exhibit remarkable anti-inflammatory activity: In vivo study

Anti-inflammatory Activity of Water Extract of Luvunga sarmentosa (BI.) Kurz Stem in the Animal Models

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