Evaluation of Antileishmanial Activities of a Peganum Harmala and Achillea Millefolium  Essential oils and their combinations against Leishmania Infantum Promastigotes

ASADOV, Elsever

doi:10.35206/jan.1174836

Cited by 3 publications

(2 citation statements)

References 24 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…After this procedure, the plate was incubated in the 5 %CO2 atmosphere for 24 hours at 37 °C. At the end of this period, the plate was read in an ELISA reader, using the colorimetric technique by MTT (Ayrom, Rasouli and Shemshadi, 2021). Thus, with the IC50 and CC50 obtained, the Selectivity Index (SI) was calculated through the following equation:…”

Section: Cytotoxicity Testmentioning

confidence: 99%

In vitro effect of alpha-bisabolol and its synthetic derivatives on macrophages, promastigotes, and amastigotes of Leishmania amazonensis and Leishmania infantum

Perin,

Parreira,

Barcelos

et al. 2023

Natural Product Research

View full text Add to dashboard Cite

Cutaneous and visceral leishmaniasis are public health problems in Africa, Asia, Europe, and America. The treatment has a high cost and toxicity. Thus, this work aims to evaluate the leishmanicidal activity of alpha-bisabolol and its three synthetic derivatives, P1, P2, and P3, on the promastigotes and amastigotes Leishmania infantum and L. amazonensis forms. Alpha-bisabolol showed the lowest IC50 with 3.43 for L. amazonensis promastigotes, while P1 was the most toxic for L. infantum with an IC50 of 9.10. The derivative P3 was better for the amastigote form, with an IC50 of 3.39 for L. amazonensis.All the compounds effectively decreased the intracellular load of amastigote and its ability to turn promastigote again. Thus, alpha-bisabolol and its three synthetic derivatives were effective in their leishmanicidal activity. Therefore, it can be an option for developing new treatments against leishmaniasis.

show abstract

Section: Cytotoxicity Testmentioning

confidence: 99%

In vitro effect of alpha-bisabolol and its synthetic derivatives on macrophages, promastigotes, and amastigotes of Leishmania amazonensis and Leishmania infantum

Perin,

Parreira,

Barcelos

et al. 2023

Natural Product Research

View full text Add to dashboard Cite

show abstract

“…Also, the plant has anthelmintic and carminative activity (Aboutable et al, 1986;Sincich, 2002), antiviral (Soltan and Zaki, 2009), antimicrobial and anticancer (Alshuail et al, 2022;Break et al, 2022), and antifungal (Alsohaili, 2018). Additionally, studies showed its antiparasitic activity such as Trypanosoma evansi (El-Ashmawy et al, 2016), Leishmania infantum (Ayrom et al, 2021), and Blastocystis (Mokhtar et al, 2019).…”

Section: Introductionmentioning

confidence: 99%

In vitro anti-eimeriosis and anthelmintic activities for Achillea fragrantissima

Al-Shaebi,

Al-Quraishy,

Maodaa

et al. 2023

Arq. Bras. Med. Vet. Zootec.

View full text Add to dashboard Cite

The effectiveness of many plants has been reported as anthelmintic and anticoccidial because they possess active compounds. Excessive use of drugs has led to the emergence of drug-resistant Eimeria species. This study was designed to evaluate anticoccidial and anthelmintic activity of Achillea fragrantissima flower extract (AFFE) and leaves extract (AFLE). Infrared spectroscopy showed nine phytochemical compounds. Chemical examination revealed AF rich in phenols, flavonoids, and tannins. Flower extract showed the highest percentage inhibition of DPPH radical at 500 µg/mL (82.2%) compared to leaves extract (74.5%). AFFE and AFLE (100 mg/ml) caused paralysis and earthworm death by 13.67±1.96 and 15.25±2.48 min and 4.19±0.05 and 4.70±0.28 min, respectively, compared to mebendazole. In histological study, a clear defect was found in surface architecture of treated groups of worms with extract. At 96 h, significant inhibition (100%) of process sporulation for E. papillata oocyst was observed when exposed to AFFE (300 and 200 mg/mL), while AFLE was 98.4 and 96%, respectively. Additionally, amprolium, DettolTM, phenol, and formalin 5% showed different levels of inhibition. Results revealed anticoccidial and anthelmintic activities of AFFE and AFLE, which encourages conducting many in vivo studies to find an effective and cheap treatment.

show abstract

Antibacterial and nematicidal activities of extracts from plants of the Asteraceae family

Zazharskyi,

Brygadyrenko,

Zazharska

et al. 2024

Regul. Mech. Biosyst.

View full text Add to dashboard Cite

Drugs based on plants of the Asteraceae family are broadly used against microorganisms that are pathogenic to people and animals. However, their potentials in this aspect have not been fully researched. In our in vitro experiment, we tested alcohol tinctures of 12 species of plants of the Asteraceae family against 10 species of bacteria, one species of fungi, and the larval stages of three species of nematodes – parasites of ruminants (L1 Muellerius capillaris, L1–3 Strongyloides papillosus, L3 Haemonchus contortus). The growth inhibition zone larger than 8 mm was observed after using ethanol extracts of the aboveground parts of several plants against the colonies of various microorganisms: Solidago canadensis showed activity against five species – Klebsiella pneumoniae, Proteus mirabilis, Shigella flexneri, Clostridium perfringens, and Candida albicans; Cyclachaena xanthiifolia was effective against five species – Escherichia coli, P. mirabilis, Enterococcus faecalis, C. perfringens, and C. albicans); Jurinea arachnoidea inhibited four species – K. pneumoniae, P. mirabilis, Pseudomonas аeruginosa, and Bacillus subtilis); Scorzoneroides autumnalis acted against four species – P. mirabilis, Sh. flexneri, C. perfringens, and C. albicans; Helichrysum arenarium demonstrated activity against four species – P. mirabilis, Sh. flexneri, E. faecalis, and Listeria monocytogenes; and extracts from the fruits of Echinops ritro were active against four species – K. pneumoniae, P. mirabilis, Staphylococcus aureus, and B. subtilis, while extracts from the flowers of Echinops ritro were effective against four microorganisms – K. pneumoniae, P. mirabilis, Sh. flexneri, and Р. аeruginosa. However, we observed no expressed nematocidal action of ethanol extracts of the studied species of plants. After 24 h exposures to 0.1% solutions of those extracts, over 95% of the nematode larvae of ruminants were found to be vital. Nonetheless, as a result of the study, those plants were recognized the most promising for further in vivo research of antibacterial activity. During the search for antibacterial and antifungal activities, the following plants were found to be the less promising: the aboveground parts of Artemisia austriaca, Lactuca serriola, Ambrosia artemisiifolia, Solidago virgaurea, roots of Artemisia vulgaris, Echinops ritro, Lactuca serriola, Solidago canadensis, Ambrosia artemisiifolia, Scorzoneroides autumnalis, and leaves of Echinops ritro.

show abstract

Evaluation of Antileishmanial Activities of a Peganum Harmala and Achillea Millefolium Essential oils and their combinations against Leishmania Infantum Promastigotes

Cited by 3 publications

References 24 publications

In vitro effect of alpha-bisabolol and its synthetic derivatives on macrophages, promastigotes, and amastigotes of Leishmania amazonensis and Leishmania infantum

In vitro effect of alpha-bisabolol and its synthetic derivatives on macrophages, promastigotes, and amastigotes of Leishmania amazonensis and Leishmania infantum

In vitro anti-eimeriosis and anthelmintic activities for Achillea fragrantissima

Antibacterial and nematicidal activities of extracts from plants of the Asteraceae family

Contact Info

Product

Resources

About