Evaluation of antimalarial and biochemical profiles of Abaleria® in Plasmodium berghei-infected mice

Adebayo, Abiodun Humphrey; Yakubu, Omolara Faith; Popoola, Jacob O.; L, David; Okenze, Gloria Nwabugwu; Amarachi, Agbafor; Okubena, Olajuwon

doi:10.1007/s00580-018-2780-8

Cited by 2 publications

(1 citation statement)

References 31 publications

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“…enzymes have previously been reported to be indicative of damage to organs such as liver, kidney and heart (Adebayo et al, 2018;Viriyavejakul et al, 2014).…”

Section: Results From Histopathological Examination Of Animals' Vital...mentioning

confidence: 99%

Clinico-biochemical and histopathological alterations in sub-chronically exposed mice (Mus Musculus) to polyherbal antimalarials

Omagha,

T Idowu,

G Alimba

et al. 2023

Drug Dicov

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Introduction: Concerns have been raised in the safety of antimalarial remedies for them to be acceptable for use. The present study is an assessment of safety profiles of two plant-based antimalarial cocktail treatments, namely: Cocktail treatment A (CtA) and Cocktail treatment B (CtB). Materials and methods: The treatments have been prepared from a defined mixture of hot water extracts of 6 plant parts, based on how they are used locally as antimalarials. CtA comprised Enantia chlorantha Oliv., Cymbopogon citratus Stapf, Curcuma longa L., while CtB comprised Enantia chlorantha Oliv., Carica papaya L., Alstonia boonei De Wild and Mangifera indica L. Safety assessments were done as post antimalarial exposures of CtA, CtB administered in mice at 200, 400 and 800 mg/kg dose levels against Plasmoduim berghei berghei. Haematological parameters, biochemical parameters, and histopathological changes of vital organs were equally evaluated for mice sacrificed immediately after exposures on day 8 (D8) (suppressive), day 9 (D9) (curative), day 12 (D12) (prophylactic), day 6 (D6) (treated/unparasitized). These results of acute effects of the treatments were compared with corresponding curative, suppressive, prophylactic, treated/unparasitized groups of treated mice which were sacrificed on day 25 (D25) for sub-chronic effects of the cocktails aganist P. berghei infected mice. Data was analyzed by using SPSS version 23.0. (p<0.05). Results: The treatments increased concentrations of packed cell volume, haemoglobin, red blood cells and white blood cells, liver enzymes and oxidative stress biomarkers. However, these concentrations returned to normal levels by day 25 (D25). Heart and spleen morphology was normal in all the treatments. But pathological damages were observed in the kidney, liver and brain, indicating multi-organ toxicities. The damages were mostly observed in groups administered 400 and 800 mg/kg doses. Conclusions: Overall, findings demonstrated some toxicities associated with CtA and CtB antimalarials that could be transient, as demonstrated in some groups of the experimental mice where haematological and some biochemical parameters were returning to normal levels within 25 days post-treatment. Cautious administrations of these

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“…enzymes have previously been reported to be indicative of damage to organs such as liver, kidney and heart (Adebayo et al, 2018;Viriyavejakul et al, 2014).…”

Section: Results From Histopathological Examination Of Animals' Vital...mentioning

confidence: 99%

Clinico-biochemical and histopathological alterations in sub-chronically exposed mice (Mus Musculus) to polyherbal antimalarials

Omagha,

T Idowu,

G Alimba

et al. 2023

Drug Dicov

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Acute toxicity and antimalarial studies of extract of Allophylus spicatus in animals

2021

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Medicinal plants produce a variety of chemical substances with varied physiological effects. They are a huge reservoir of various chemical substances with potential therapeutic properties. Allophylus spicatus is a shrub that belong to the Sapindaceae family. In this study, male albino wistar rats (18) were used for acute toxicity test. Animals were divided into six groups of three rats each. Group A served as the control group while the other groups were dosed orally with 200, 500, 1000, 2000 and 5000 mg/kg body weight of extract and were observed for 14 days. Swiss albino mice (42) were used for the antimalarial study; five groups of six infected mice per group (Groups C-G) were respectively dosed orally with 25 mg chloroquine/kg bw, 200 mg of extract/kg bw, 400 mg/kg bw of extract, 25 mg chl./kg bw + 200 mg/kg bw of extract and 25 mg chl./kg bw + 400 mg/kg bw extract with three groups serving as the control (Groups A-C) for three days. Acute toxicity test and histology analysis on the liver tissue confirmed the safety of the extract at concentrations less than 1000 mg/kg b/w. Antimalarial studies showed the highest activity in the group administered with 400 mg/kg + 25 mg chl./kg b/w. In conclusion, A. spicatus was non-toxic at doses less than 1000 mg/kg and significantly reduced parasitemia count in P. berghei infected mice, thus validating its folkloric usage.

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Evaluation of antimalarial and biochemical profiles of Abaleria® in Plasmodium berghei-infected mice

Cited by 2 publications

References 31 publications

Clinico-biochemical and histopathological alterations in sub-chronically exposed mice (Mus Musculus) to polyherbal antimalarials

Clinico-biochemical and histopathological alterations in sub-chronically exposed mice (Mus Musculus) to polyherbal antimalarials

Acute toxicity and antimalarial studies of extract of Allophylus spicatus in animals

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