Evaluation of antimicrobial activity of rambutan (Nephelium lappaceum L.) peel extracts

Phuong, Nguyen Nhat Minh; Le, Thien Trung; Camp, John Van

doi:10.1016/j.ijfoodmicro.2020.108539

Cited by 42 publications

(44 citation statements)

References 45 publications

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“…Rambutan peel extract is rich in phenolic content and exhibited antibacterial activity against many pathogenic bacteria, suggesting its antioxidant and/or antimicrobial properties [2]. Rambutan has the potential to be used in natural antioxidants and anti-aging agents in pharmaceutical and food industries to replace synthetic ones [3,4].…”

Section: Introductionmentioning

confidence: 99%

Chloroplast Genome of Rambutan and Comparative Analyses in Sapindaceae

Dong

Lin

et al. 2021

Plants

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Rambutan (Nephelium lappaceum L.) is an important fruit tree that belongs to the family Sapindaceae and is widely cultivated in Southeast Asia. We sequenced its chloroplast genome for the first time and assembled 161,321 bp circular DNA. It is characterized by a typical quadripartite structure composed of a large (86,068 bp) and small (18,153 bp) single-copy region interspersed by two identical inverted repeats (IRs) (28,550 bp). We identified 132 genes including 78 protein-coding genes, 29 tRNA and 4 rRNA genes, with 21 genes duplicated in the IRs. Sixty-three simple sequence repeats (SSRs) and 98 repetitive sequences were detected. Twenty-nine codons showed biased usage and 49 potential RNA editing sites were predicted across 18 protein-coding genes in the rambutan chloroplast genome. In addition, coding gene sequence divergence analysis suggested that ccsA, clpP, rpoA, rps12, psbJ and rps19 were under positive selection, which might reflect specific adaptations of N. lappaceum to its particular living environment. Comparative chloroplast genome analyses from nine species in Sapindaceae revealed that a higher similarity was conserved in the IR regions than in the large single-copy (LSC) and small single-copy (SSC) regions. The phylogenetic analysis showed that N. lappaceum chloroplast genome has the closest relationship with that of Pometia tomentosa. The understanding of the chloroplast genomics of rambutan and comparative analysis of Sapindaceae species would provide insight into future research on the breeding of rambutan and Sapindaceae evolutionary studies.

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Section: Introductionmentioning

confidence: 99%

Chloroplast Genome of Rambutan and Comparative Analyses in Sapindaceae

Dong

Lin

et al. 2021

Plants

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“…Among these, only 21 of the 54 compounds (with above 86% MFG scores) of the EA(S) fractions have been reported to possess antibacterial activities (Table S3 ). Interestingly, most of them have been newly reported (within the last five years) including L2 42 , L3 43 , L6 44 , L10 46 , L12 47 , L16 48 , L20 49 , L22 51 , L26 52 , L28 53 , L31 54 , L46 58 , L48 59 , L51 60 , L53 61 and L54 59 . Others are known for some time, namely, L7 45 , L21 50 , L35 55 , L37 56 and L45 57 .…”

Section: Discussionmentioning

confidence: 99%

“…Of these, except for L24 55 and L35 58 , all were reported recently. These included L2 44 , L5 62 , L10 48 , L13 52 , L19 54 , L36 58 , L38 59 and L42 61 . Thus, possibilities exist for those 35 and 26 compounds from EA(S) and AC(S) fractions, respectively, with no matched identity with the library (Table S6 & S7 ) to be medically important, though, further characterization is required to evaluate their usages.…”

Section: Discussionmentioning

confidence: 99%

A scaffolded approach to unearth potential antibacterial components from epicarp of Malaysian Nephelium lappaceum L.

Ali

Tan

Zahoor

et al. 2021

Sci Rep

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The emergence and spread of antimicrobial resistance have been of serious concern to human health and the management of bacterial infectious diseases. Effective treatment of these diseases requires the development of novel therapeutics, preferably free of side effects. In this regard, natural products are frequently conceived to be potential alternative sources for novel antibacterial compounds. Herein, we have evaluated the antibacterial activity of the epicarp extracts of the Malaysian cultivar of yellow rambutan fruit (Nephelium lappaceum L.) against six pathogens namely, Bacillus subtilis, methicillin-resistant Staphylococcus aureus (MRSA), Streptococcus pyogenes, Pseudomonas aeruginosa, Klebsiella pneumoniae and Salmonella enterica. Among a series of solvent extracts, fractions of ethyl acetate and acetone have revealed significant activity towards all tested strains. Chemical profiling of these fractions, via HPLC, LC–MS and GC–MS, has generated a library of potentially bioactive compounds. Downstream virtual screening, pharmacological prediction, and receptor-ligand molecular dynamics simulation have eventually unveiled novel potential antibacterial compounds, which can be extracted for medicinal use. We report compounds like catechin, eplerenone and oritin-4-beta-ol to be computationally inhibiting the ATP-binding domain of the chaperone, DnaK of P. aeruginosa and MRSA. Thus, our work follows the objective to propose new antimicrobials capable of perforating the barrier of resistance posed by both the gram positives and the negatives.

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“…of 22 Interestingly, some studies report that the high quantity of polyphenols present in all plant parts can explain most of the antifungal effects of diverse plant extracts. Several of these polyphenols are identified as ellagic acid and caffeic acid derivatives [65][66][67][68][69][70][71]. Rangkadilok et al (2012) showed that ellagic acid displayed the most potent antifungal activity among polyphenols detected in longan seed extracts [72].…”

Section: Discussionmentioning

confidence: 99%

Antifungal Activity of the Phenolic Compounds Ellagic Acid (EA) and Caffeic Acid Phenethyl Ester (CAPE) against Drug-Resistant Candida auris

Rossatto

Tharmalingam

Escobar

et al. 2021

JoF

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Candida auris is an emerging healthcare-associated fungal pathogen that has become a serious global health threat. Current treatment options are limited due to drug resistance. New therapeutic strategies are required to target this organism and its pathogenicity. Plant polyphenols are structurally diverse compounds that present a vast range of biological properties. In the present study, plant-derived molecules ellagic acid (EA) and caffeic acid phenethyl ester (CAPE) were investigated for their antifungal and antivirulence activities against Candida auris. We also tested against C. albicans. The minimum inhibitory concentration (MIC) for EA ranged from 0.125 to 0.25 µg/mL and for CAPE ranged from 1 to 64 µg/mL against drug-resistant C. auris strains. Killing kinetics determined that after 4 h treatment with CAPE, there was a complete reduction of viable C. auris cells compared to fluconazole. Both compounds might act by modifying the fungal cell wall. CAPE significantly reduced the biomass and the metabolic activity of C. auris biofilm and impaired C. auris adhesion to cultured human epithelial cells. Furthermore, both compounds prolonged the survival rate of Galleria mellonella infected by C. auris (p = 0.0088 for EA at 32 mg/kg and p = 0.0028 for CAPE at 4 mg/kg). In addition, EA at 4 μg/mL prolonged the survival of C. albicans-infected Caenorhabditis elegans (p < 0.0001). CAPE was not able to prolong the survival of C. albicans-infected C. elegans. These findings highlight the antifungal and antivirulence effects of EA and CAPE against C. auris, and warrant further investigation as novel antifungal agents against drug-resistant infections.

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Evaluation of antimicrobial activity of rambutan (Nephelium lappaceum L.) peel extracts

Cited by 42 publications

References 45 publications

Chloroplast Genome of Rambutan and Comparative Analyses in Sapindaceae

Chloroplast Genome of Rambutan and Comparative Analyses in Sapindaceae

A scaffolded approach to unearth potential antibacterial components from epicarp of Malaysian Nephelium lappaceum L.

Antifungal Activity of the Phenolic Compounds Ellagic Acid (EA) and Caffeic Acid Phenethyl Ester (CAPE) against Drug-Resistant Candida auris

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