Evaluation of antimicrobial activity of association of chlorhexidine to photosensitizer used in photodynamic therapy in root canals infected by Enterococcus faecalis

Souza, Matheus Albino; Lima, Guilherme; Pazinatto, Bianca; Bischoff, Karolina Frick; Palhano, Huriel Scartazzini; Cecchin, Doglas

doi:10.1016/j.pdpdt.2017.06.007

Cited by 7 publications

(3 citation statements)

References 34 publications

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“…In this study, the combination of CHX and aPDT treatment was more effective than CHX or aPDT alone in reducing the number of P. gingivalis on both polished and SLA titanium surfaces. Few reports have been published regarding the concurrent application of CHX and aPDT in eradicating endodontic (44,45) or periodontal pathogens (42). Hoedke et al evaluated the antibacterial effects of aPDT with different irrigation solutions on a multispecies biofilm in root canals ex vivo.…”

Section: Discussionmentioning

confidence: 99%

Disinfect Porphyromonas gingivalis Biofilm on Titanium Surface with Combined Application of Chlorhexidine and Antimicrobial Photodynamic Therapy

Cai

Wang

et al. 2018

Photochem & Photobiology

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Various antimicrobial modalities have been proposed to treat peri‐implantitis but resulted in limited outcomes. The aim of this in vitro study was to evaluate the disinfection efficacy of combined application of chlorhexidine digluconate (CHX) and antimicrobial photodynamic therapy (aPDT) of titanium surfaces previously contaminated with Porphyromonas gingivalis biofilm. P. gingivalis biofilms were grown on 32 polished and 32 sandblasted large‐grit acid‐etched (SLA) titanium surfaces. Titanium disks were allocated into four groups as follows: (1) immersed in phosphate‐buffered saline (PBS), (2) immersed in 0.2% CHX, (3) application of aPDT and (4) immersed in 0.2% CHX and subsequent aPDT. Residual bacteria were determined by microbial culture analysis and by scanning electron microscopy (SEM) and confocal laser scanning microscopy (CLSM) imaging. Combination protocol (CHX+ aPDT) was the most effective in eradicating P. gingivalis (P < 0.05) on both polished and SLA surfaces. There was no significant difference in the number of remaining P. gingivalis between polished titanium disks and the SLA ones in four groups (P > 0.05). Under the limitation of this study, combined technique of preceding application of CHX and subsequent aPDT was shown to be an efficient method in reducing P. gingivalis numbers in both polished and SLA titanium surfaces.

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Section: Discussionmentioning

confidence: 99%

Disinfect Porphyromonas gingivalis Biofilm on Titanium Surface with Combined Application of Chlorhexidine and Antimicrobial Photodynamic Therapy

Cai

Wang

et al. 2018

Photochem & Photobiology

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“…The development of low intensity diode lasers with monochromatic and coherent light facilitated the association with photosensitizers with a resonant absorption band with the wavelength emitted by the laser (8). The laser most commonly used in PDT studies was the Diode laser, with power protocols in the range of 100 mW (3,18,20). However, a direct comparison between them is difficult, due to the discrepancies between the laser use protocols used in the methodologies5.…”

Section: Revisão Da Literaturamentioning

confidence: 99%

Photodynamic therapy in endodontics: literature review.

Damasceno¹,

M²

2021

Braz. J. Implantol. Health Sci.

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Endodontic therapy seeks to prevent and when necessary to eliminate endodontic infections. The persistence of microorganisms to the mechanical chemical preparation or the intracanal medication is considered the main cause of the failures of the endodontic treatment. In these cases Enterococcus faecalis is the most commonly found microorganism. Photodynamic therapy (PDT) emerges as a promising adjuvant therapy to conventional endodontic treatment to eliminate these persistent microorganisms. This therapy consists in the association of a specific light source with a photosensitizer in the presence of oxygen, producing cytotoxic species to the microorganisms. Thus, the present article aims at a review of the literature on the use of photodynamic therapy in endodontics, a test that is shown to assist in the preparation of the root canal.

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“…O desenvolvimento dos lasers de diodo de baixa intensidade com luz monocromática e coerente facilitou a associação com fotossensibilizadores com banda de absorção ressonante com o comprimento de onda emitida pelo laser (8). O laser mais comumente utilizado nos estudos da PDT foi o laser Diodo, com protocolos de potência na faixa dos 100 mW (3,18,20). Contudo, uma comparação direta entre os mesmos é difícil, devido às discrepâncias entre os protocolos de uso do laser utilizados nas metodologias 5 .…”

Section: Revisão De Literaturaunclassified

Terapia fotodinâmica na endodontia: revisão de literatura

Schaeffer¹,

D'Aviz²,

Ghiggi

et al. 2019

JOI

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A terapia endodôntica busca prevenir e quando necessário eliminar infecções endodônticas. A persistência de microrganismos ao preparo químico mecânico ou a medicação intracanal é considerada a principal causa dos insucessos do tratamento endodôntico. Sendo nestes casos o Enterococcus faecalis o microrganismo mais comumente encontrado. A terapia fotodinâmica (PDT) desponta desta maneira como uma promissora terapia coadjuvante ao tratamento endodôntico convencional para eliminar estes microrganismos persistentes. Esta terapia consiste na associação de uma fonte de luz específica a um fotossensibilizador na presença de oxigênio, produzindo assim espécies citotóxicas aos microrganismos. Assim, o presente artigo tem como objetivo realizar uma revisão de literatura sobre o uso da terapia fotodinâmica na endodontia, a qual demonstra-se efetiva como auxiliar durante o preparo do canal radicular.

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Evaluation of antimicrobial activity of association of chlorhexidine to photosensitizer used in photodynamic therapy in root canals infected by Enterococcus faecalis

Cited by 7 publications

References 34 publications

Disinfect Porphyromonas gingivalis Biofilm on Titanium Surface with Combined Application of Chlorhexidine and Antimicrobial Photodynamic Therapy

Disinfect Porphyromonas gingivalis Biofilm on Titanium Surface with Combined Application of Chlorhexidine and Antimicrobial Photodynamic Therapy

Photodynamic therapy in endodontics: literature review.

Terapia fotodinâmica na endodontia: revisão de literatura

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